Catalog No.
YHK04501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asn207
Predicted molecular weight
25.77 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HC77
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LYST-interacting protein 1, CPAP, LAP, LAG-3-associated protein, LIP1, Centrosomal P4.1-associated protein, CENPJ, Centromere protein J, CENP-J
Centrobin serves as a safeguard to guide timely centriole maturation during the cell cycle., PMID:40102598
Centriolar cap proteins CP110 and CPAP control slow elongation of microtubule plus ends., PMID:39847124
Clinical genomics expands the link between erroneous cell division, primary microcephaly and intellectual disability., PMID:38795246
Separation-of-function MCPH-associated mutations in CPAP affect centriole number and length., PMID:37823337
Downregulation of Microcephaly-Causing Genes as a Mechanism for ZIKV Teratogenesis: A Meta-analysis of RNA-Seq Studies., PMID:37428363
Microcephaly, Short Stature, Intellectual Disability, Speech Absence and Cataract Are Associated with Novel Bi-Allelic Missense Variant in RTTN Gene: A Seckel Syndrome Case Report., PMID:37371259
Genetic and protein interaction studies between the ciliary dyslexia candidate genes DYX1C1 and DCDC2., PMID:37237337
Expanding the phenotype of Seckel syndrome associated with biallelic loss-of-function variants in CEP63., PMID:37017437
Hydranencephaly in CENPJ-related Seckel syndrome., PMID:36334884
Analysis of Ser/Thr Kinase HASPIN-Interacting Proteins in the Spermatids., PMID:36012324
Centromere protein J is overexpressed in human glioblastoma and promotes cell proliferation and migration., PMID:35797221
A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection., PMID:35738280
A novel leaky splice variant in centromere protein J (CENPJ)-associated Seckel syndrome., PMID:35451063
Signature constructed by glycolysis-immune-related genes can predict the prognosis of osteosarcoma patients., PMID:35435626
CPAP insufficiency leads to incomplete centrioles that duplicate but fragment., PMID:35404385
The Higher Expression of CDCA2 Associated with Poor Prognosis in Glioma., PMID:35386230
Modeling Human Primary Microcephaly With hiPSC-Derived Brain Organoids Carrying CPAP-E1235V Disease-Associated Mutant Protein., PMID:35309908
Identification of Pathogenic Mutations in Primary Microcephaly- (MCPH-) Related Three Genes CENPJ, CASK, and MCPH1 in Consanguineous Pakistani Families., PMID:35281599
Microcephaly gene Cenpj regulates axonal growth in cortical neurons through microtubule destabilization., PMID:34940974
Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity., PMID:34932949
CPAP enhances and maintains chronic inflammation in hepatocytes to promote hepatocarcinogenesis., PMID:34686650
Centrosomal P4.1-associated protein (CPAP) positively regulates endocytic vesicular transport and lysosome targeting of EGFR., PMID:34135376
Modifier Genes in Microcephaly: A Report on WDR62, CEP63, RAD50 and PCNT Variants Exacerbating Disease Caused by Biallelic Mutations of ASPM and CENPJ., PMID:34068194
High expression levels of centromere protein A plus upregulation of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway affect chemotherapy response and prognosis in patients with breast cancer., PMID:33841571
Molecular Diversity of Clinically Stable Human Kidney Allografts., PMID:33492376
Keep Garfagnina alive. An integrated study on patterns of homozygosity, genomic inbreeding, admixture and breed traceability of the Italian Garfagnina goat breed., PMID:33449925
Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice., PMID:32803714
An update of pathogenic variants in ASPM, WDR62, CDK5RAP2, STIL, CENPJ, and CEP135 underlying autosomal recessive primary microcephaly in 32 consanguineous families from Pakistan., PMID:32677750
Unusual context of CENPJ variants and primary microcephaly: compound heterozygosity and nonconsanguinity in an Argentinian patient., PMID:32549991
Loss of CPAP in developing mouse brain and its functional implication for human primary microcephaly., PMID:32501282
Cooperative unfolding of a single-layer β-sheet protein, CPAP G-box., PMID:32197835
The association of microcephaly protein WDR62 with CPAP/IFT88 is required for cilia formation and neocortical development., PMID:31816041
CPAP promotes angiogenesis and metastasis by enhancing STAT3 activity., PMID:31511651
Growth Hormone Promotes in vitro Maturation of Human Oocytes., PMID:31396155
Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis., PMID:31170980
Cenpj Regulates Cilia Disassembly and Neurogenesis in the Developing Mouse Cortex., PMID:30626697
Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells., PMID:30530478
DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex., PMID:30329130
Alcohol inhibits the proliferation of Neuro2a cells via promoting the asymmetric cell division through down-regulation of the expression of centrosome protein-J., PMID:29778912
The genetics of congenitally small brains., PMID:28912110
FOXF1 transcription factor promotes lung regeneration after partial pneumonectomy., PMID:28878348
Molecular genetic analysis of consanguineous families with primary microcephaly identified pathogenic variants in the ASPM gene., PMID:28674240
Identification of β-catenin-interacting proteins in nuclear fractions of native rat collecting duct cells., PMID:28298358
Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate., PMID:27974163
Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length., PMID:27306797
Centriolar CPAP/SAS-4 Imparts Slow Processive Microtubule Growth., PMID:27219064
Phosphorylation of CPAP by Aurora-A Maintains Spindle Pole Integrity during Mitosis., PMID:26997271
CPAP promotes timely cilium disassembly to maintain neural progenitor pool., PMID:26929011
Genetic causes of MCPH in consanguineous Pakistani families., PMID:26548919
The centriolar protein CPAP G-box: an amyloid fibril in a single domain., PMID:26517891
For research use only. Not for human or drug use.
