Catalog No.
YHK04401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp279-Val515
Predicted molecular weight
29.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q969H0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SEL10, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, FBW7, Archipelago homolog, hCdc4, SEL-10, hAgo, F-box/WD repeat-containing protein 7, FBX30, FBXW7
Disruption of KLHL37-N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse models., PMID:40493396
NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids., PMID:40441890
NAP1L1 degradation by FBXW7 reduces the deubiquitination of HDGF-p62 signaling to stimulate autophagy and induce primary cisplatin chemosensitivity in nasopharyngeal carcinoma., PMID:40414865
YTHDF1 activates FBW7 transcription by regulating m6A-dependent FOXO1 to facilitate inflammatory response in ulcerative colitis-like model., PMID:40384634
TTC36 promotes proliferation and drug resistance in hepatocellular carcinoma cells by inhibiting c-Myc degradation., PMID:40274799
Peptides based on the interface of hnRNPA2B1-transthyretin complex repress retinal angiogenesis in diabetic retinopathy., PMID:40253339
USP28 promotes PARP inhibitor resistance by enhancing SOX9-mediated DNA damage repair in ovarian cancer., PMID:40240356
A novel mechanism of FBXW7 in combating intervertebral disc degeneration: Mitigating ferroptosis in nucleus pulposus cells through the regulation of mitophagy., PMID:40239332
Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation., PMID:40215968
Mai-wei-yang-fei decoction protects against pulmonary fibrosis by reducing telomere shortening and inhibiting AECII senescence via FBW7/TPP1 regulation., PMID:40215816
SOX9-dependent fibrosis drives renal function in nephronophthisis., PMID:40211043
ECPPF stratification identifies occult high-risk subgroups in stage I, grade 1 or 2, ≤50 % invasive endometrial cancer: Candidates for adjuvant therapy., PMID:40199195
Mechanism of FBXW7 mRNA degradation mediated by circSMAD2 through METTL3-METTL14 m6A axis affects proliferation and invasion of endometrial stromal cells., PMID:40184726
The FBXW7-KMT2 axis in cancer-associated fibroblasts controls tumor growth via an epigenetic-paracrine mechanism., PMID:40127278
Targeting BARD1 suppresses a Myc-dependent transcriptional program and tumor growth in pancreatic ductal adenocarcinoma., PMID:40096771
Proteomic Changes Associated With Endogenous FBXW7 Mutations in Moderately Differentiated Endometrial Cancer Cells Include Increased TROP2 and Galectin-3 Levels., PMID:40087851
FBXW7/GSK3β-mediated proline-rich 11 degradation promotes oxidative DNA damage and inhibits tumor progression in renal cell carcinoma., PMID:40083925
Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer., PMID:40075071
PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer., PMID:40033101
FBXW7 mediates high glucose-induced epithelial to mesenchymal transition via KLF5 in renal tubular cells of diabetic kidney disease., PMID:40010183
Comprehensive genomic analysis in sporadic early-onset colorectal adenocarcinoma patients., PMID:40001005
ASH2L Deficiency in Smooth Muscle Drives Pulmonary Vascular Remodeling., PMID:39996311
FBXW7 Directly Ubiquitinates and Degrades CTNNB1 Mediating the Suppression of ENKUR in Endometrial Cancer., PMID:39990660
STYX Interacts with FBXW7 to Promote AML Proliferation via Inhibiting the Ubiquitination of CCNE1., PMID:39962032
Association of non-gain-of-function alterations in exportin-1 with improved overall survival in colorectal cancer., PMID:39947513
The FBXW7-RPAP2 Axis Controls the Growth of Hepatocellular Carcinoma Cells and Determines the Fate of Liver Cell Differentiation., PMID:39932049
Sulfatase modifying factor 2 as a predictive biomarker for urothelial carcinoma., PMID:39915362
Harnessing the FBXW7 Somatic Mutant R465C for Targeted Protein Degradation., PMID:39913332
Unveiling the intriguing relationship: oncogenic KRAS, morphological shifts, and mutational complexity in pancreatic mucinous cystic neoplasms., PMID:39906959
Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells., PMID:39827156
FBXW7 metabolic reprogramming inhibits the development of colon cancer by down-regulating the activity of arginine/mToR pathways., PMID:39823500
Squamocin Suppresses Tumor Growth through Triggering an Endoplasmic Reticulum Stress-Associated Degradation of EZH2/MYC Axis., PMID:39823459
Correlations of the expression of Cx43, SCFFBXW7, p-cyclin E1 (Ser73), p-cyclin E1 (Thr77) and p-cyclin E1 (Thr395) in colon cancer tissues., PMID:39817129
Missense variants weakening a SOX9 phosphodegron linked to odontogenesis defects, scoliosis, and other skeletal features., PMID:39797402
Spliced exon9 ADRM1 promotes liver oncogenicity via selective degradation of tumor suppressor FBXW7., PMID:39788431
HIF-2α/LPCAT1 orchestrates the reprogramming of lipid metabolism in ccRCC by modulating the FBXW7-mediated ubiquitination of ACLY., PMID:39781455
Mutational and co-mutational landscape of early onset colorectal cancer., PMID:39761813
E3 ligase FBXW7 suppresses brown fat expansion and browning of white fat., PMID:39747664
Altered TP53, CDKN2A, ATM, EPHA7, POT1, CHEK1, GRIN2A, and EGFR Predict Shorter Survival in Penile Squamous Cell Carcinoma., PMID:39694330
Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation., PMID:39677626
POLE-Mutated Uterine Carcinosarcomas: A Clinicopathologic and Molecular Study of 11 Cases., PMID:39615841
Clinical significance of NOTCH1 and FBXW7 alterations in adult T-cell leukemia/lymphoma., PMID:39586983
Role for the F-box proteins in heart diseases., PMID:39577754
YAP acts as an independent prognostic marker and regulates growth and metastasis of gastrointestinal stromal tumors via FBXW7-YAP pathway., PMID:39557657
MDM2 drives resistance to Osimertinib by contextually disrupting FBW7-mediated destruction of MCL-1 protein in EGFR mutant NSCLC., PMID:39543744
LncRNA GClnc1 promotes osteosarcoma progression by stabilizing NONO and blocking FBXW7-mediated ubiquitination., PMID:39523321
F-Box and WD repeat domain containing 7 induces infectious osteomyelitis by regulating MYB stability and ubiquitination., PMID:39487565
FBW7-Mediated Degradation of CHD3 Suppresses Hepatocellular Carcinoma Metastasis and Stemness to Enhance Oxaliplatin Sensitivity., PMID:39473409
PGC-1α regulation by FBXW7 through a novel mechanism linking chaperone-mediated autophagy and the ubiquitin-proteasome system., PMID:39429232
Molecular profiling of oral epithelial dysplasia and oral squamous cell carcinoma using next generation sequencing., PMID:39424062
For research use only. Not for human or drug use.
