Catalog No.
YHK04201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg93-Leu214
Predicted molecular weight
15.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y4Z2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NGN-3, BHLHA7, Protein atonal homolog 5, NGN3, bHLHa7, Class A basic helix-loop-helix protein 7, Neurogenin-3, ATOH5, NEUROG3
Effects of Neurogenin 3 Induction on Endocrine Differentiation and Delamination in Adult Human Pancreatic Ductal Organoids., PMID:40236756
Ductal or Ngn3+ cells do not contribute to adult pancreatic islet beta-cell neogenesis in homeostasis., PMID:40205162
The Genetic Architecture of Congenital Diarrhea and Enteropathy., PMID:40174224
The expression order determines the pioneer functions of NGN3 and NEUROD1 in pancreatic endocrine differentiation., PMID:40138419
Salt-inducible kinases transduce mechanical forces into the specification of the pancreatic endocrine lineage., PMID:40054471
Ginger extract promotes pancreatic islets regeneration in streptozotocin-induced diabetic rats., PMID:40014427
Dual PPAR-α/γ enhances beta cell identity, preserving islet structure in HF-fed mice., PMID:39437175
From iPSCs to Pancreatic β Cells: Unveiling Molecular Pathways and Enhancements with Vitamin C and Retinoic Acid in Diabetes Research., PMID:39273600
Garlic Extract Promotes Pancreatic Islet Neogenesis Through α-to-β-Cell Transdifferentiation and Normalizes Glucose Homeostasis in Diabetic Rats., PMID:39205537
MODY Only Monogenic? A Narrative Review of the Novel Rare and Low-Penetrant Variants., PMID:39201476
Hippo pathway-mediated YAP1/TAZ inhibition is essential for proper pancreatic endocrine specification and differentiation., PMID:39051998
The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo., PMID:38958700
Calorie restriction activates a gastric Notch-FOXO1 pathway to expand ghrelin cells., PMID:38958606
Forward programming of hiPSCs towards beta-like cells using Ngn3, Pdx1, and MafA., PMID:38871849
RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function., PMID:38743124
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation., PMID:38733993
A hydrolyzed casein diet promotes Ngn3 controlling enteroendocrine cell differentiation to increase gastrointestinal motility in mice., PMID:38227487
Integrating single-cell imaging and RNA sequencing datasets links differentiation and morphogenetic dynamics of human pancreatic endocrine progenitors., PMID:37591246
USP7 controls NGN3 stability and pancreatic endocrine lineage development., PMID:37117185
Single-cell transcriptome analysis of NEUROG3+ cells during pancreatic endocrine differentiation with small molecules., PMID:37098639
Matters arising: Insufficient evidence that pancreatic β cells are derived from adult ductal Neurog3-expressing progenitors., PMID:37028408
Direct reprogramming of human fibroblasts into insulin-producing cells using transcription factors., PMID:36964318
MafB-dependent neurotransmitter signaling promotes β cell migration in the developing pancreas., PMID:36897571
Enteroendocrine Cells Protect the Stem Cell Niche by Regulating Crypt Metabolism in Response to Nutrients., PMID:36608902
A Case of Diabetes Mellitus Type MODY5 as a Feature of 17q12 Deletion Syndrome., PMID:36511482
Prolonged activation of NMDA receptors induces dedifferentiation of islet β cells in mice., PMID:36411701
Fetal Programming of the Endocrine Pancreas: Impact of a Maternal Low-Protein Diet on Gene Expression in the Perinatal Rat Pancreas., PMID:36232358
Novel Variants and Phenotypes in NEUROG3-Associated Syndrome., PMID:36149814
Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster., PMID:35998583
MafB Maintains β-Cell Identity under MafA-Deficient Conditions., PMID:35862726
Cell and chromatin transitions in intestinal stem cell regeneration., PMID:35738677
Single-cell transcriptome and accessible chromatin dynamics during endocrine pancreas development., PMID:35733248
Transcription Factors in Deriving β Cell Regeneration: A Potential Novel Therapeutic Target., PMID:34931980
Hepatocyte Nuclear Factor 4-α (HNF4α) controls the insulin resistance-induced pancreatic β-cell mass expansion., PMID:34902439
Goblet cell hyperplasia is not epithelial-autonomous in the Cftr knockout intestine., PMID:34878935
Loss of TBX3 enhances pancreatic progenitor generation from human pluripotent stem cells., PMID:34653400
Gene Signatures of NEUROGENIN3+ Endocrine Progenitor Cells in the Human Pancreas., PMID:34566896
Bioinformatics analysis of key genes and potential mechanism in cadmium-induced breast cancer progression., PMID:34558042
Protein Production and Purification of a Codon-Optimized Human NGN3 Transcription Factor from E. coli., PMID:34550497
Ngn3-Positive Cells Arise from Pancreatic Duct Cells., PMID:34445257
Differentiation of Human-Induced Pluripotent Stem Cell-Derived Endocrine Progenitors to Islet-like Cells Using a Dialysis Suspension Culture System., PMID:34440786
Genetic and clinical heterogeneity of permanent neonatal diabetes mellitus: a single tertiary centre experience., PMID:34426871
New hPSC SOX9 and INS Reporter Cell Lines Facilitate the Observation and Optimization of Differentiation into Insulin-Producing Cells., PMID:34415483
H3K4 Trimethylation Is Required for Postnatal Pancreatic Endocrine Cell Functional Maturation., PMID:34376477
Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network., PMID:34352411
Breast milk MSCs upregulated β-cells PDX1, Ngn3, and PCNA expression via remodeling ER stress /inflammatory /apoptotic signaling pathways in type 1 diabetic rats., PMID:34004210
Genetic Enteropathies Linked to Epithelial Structural Abnormalities and Enteroendocrine Deficiency: A Systematic Review., PMID:33976085
Effect of NEUROG3 polymorphism rs144643855 on regional spontaneous brain activity in major depressive disorder., PMID:33878431
Insights into the etiology and physiopathology of MODY5/HNF1B pancreatic phenotype with a mouse model of the human disease., PMID:33527355
Essential roles of insulin and IGF-1 receptors during embryonic lineage development., PMID:33453419
For research use only. Not for human or drug use.
