Catalog No.
YHK03501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser27-Ser254
Predicted molecular weight
26.72 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y5K2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PRSS17, KLK4, KLK-L1, Prostase, PSTS, Serine protease 17, Enamel matrix serine proteinase 1, Kallikrein-4, Kallikrein-like protein 1, EMSP1
IGF2BP3 facilitates the osteogenic differentiation of bone marrow mesenchyml stem cells via upregulating KLK4., PMID:39988894
Posteruptive Loss of Proteins in Porcine Enamel., PMID:39725879
The sensory nerve regulates stem cell homeostasis through Wnt5a signaling., PMID:39635121
Hypoxic Regulation of the KLK4 Gene in two Different Prostate Cancer Cells Treated with TGF- β., PMID:39026058
Polymorphisms in ENAM, AMBN, and KLK4 predispose Egyptian adults to dental caries: A cross-sectional study., PMID:38883909
Proteolytic profiles of two isoforms of human AMBN expressed in E. coli by MMP-20 and KLK-4 proteases., PMID:38298721
Kallikrein-Related Peptidase 4 Promotes Proliferation, Migration, Invasion, and Pro-Angiogenesis of Endometrial Stromal Cells via Regulation of Brain-Derived Neurotrophic Factor Production in Endometriosis., PMID:37918799
A blood-based composite panel that screens Alzheimer's disease., PMID:37194047
Deciphering the functions of Stromal Interaction Molecule-1 in amelogenesis using AmelX-iCre mice., PMID:36935757
Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process., PMID:36929047
Distinct Expression of Surface and Genetic Biomarkers in Prostate Cancer Cell Lines., PMID:36593027
Polymorphisms in genes expressed during amelogenesis and their association with dental caries: a case-control study., PMID:36422720
KLK4 Silencing Inhibits the Growth of Chromophobe Renal Cell Carcinoma through ERK/AKT Signaling Pathway., PMID:36260980
Loss of KLK4::KLKP1 pseudogene expression by RNA chromogenic in-situ hybridization is associated with PTEN loss and increased risk of biochemical recurrence in a cohort of middle eastern men with prostate cancer., PMID:35982181
Diagnostic and Prognostic Protein Biomarkers of β-Cell Function in Type 2 Diabetes and Their Modulation with Glucose Normalization., PMID:35323639
Novel KLK4 Mutations Cause Hypomaturation Amelogenesis Imperfecta., PMID:35207639
Label-free quantitative proteomics reveals molecular correlates of altered biomechanical properties in molar incisor hypomineralization (MIH): an in vitro study., PMID:35013981
KLK4T2 Is a Hormonally Regulated Transcript from the KLK4 Locus., PMID:34884832
NaF reduces KLK4 expression by decreasing Foxo1/Runx2 expression in LS8 cells., PMID:34781073
A Brief History of the Discovery of Amelogenin Nanoribbons In Vitro and In Vivo., PMID:34612757
Urine peptidome analysis in cardiorenal syndrome reflects molecular processes., PMID:34376786
A KLK4 proteinase substrate capture approach to antagonize PAR1., PMID:34373558
Structural studies of complexes of kallikrein 4 with wild-type and mutated forms of the Kunitz-type inhibitor BbKI., PMID:34342281
lncRNA IGF2-AS promotes the osteogenic differentiation of bone marrow mesenchymal stem cells by sponging miR-3,126-5p to upregulate KLK4., PMID:34101307
Calcium mitigates fluoride-induced kallikrein 4 inhibition via PERK/eIF2α/ATF4/CHOP endoplasmic reticulum stress pathway in ameloblast-lineage cells., PMID:33667956
Epitope mapping of anti-amelogenin IgG in untreated celiac children., PMID:33656197
Detection of Kallikrein-Related Peptidase 4 with a Label-free Electrochemical Impedance Biosensor Based on a Zinc(II) Phthalocyanine Tetracarboxylic Acid-Functionalized Disposable Indium Tin Oxide Electrode., PMID:33583176
Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of kallikrein‑related peptidase 4 and tight junction proteins in ameloblasts., PMID:32626909
Pathogenesis of Molar Hypomineralisation: Hypomineralised 6-Year Molars Contain Traces of Fetal Serum Albumin., PMID:32595522
Kallikrein-related peptidase 4 promotes migration and invasion of endometrial stromal cells in endometriosis by inducing epithelial-mesenchymal transition., PMID:32400148
Prespecified 4-Kallikrein Marker Model at Age 50 or 60 for Early Detection of Lethal Prostate Cancer in a Large Population Based Cohort of Asymptomatic Men Followed for 20 Years., PMID:32125228
MicroRNA-378-3p/5p represses proliferation and induces apoptosis of oral squamous carcinoma cells via targeting KLK4., PMID:31868942
MiR-378a-5p inhibits angiogenesis of oral squamous cell carcinoma by targeting KLK4., PMID:31829025
Calcium promotes differentiation in ameloblast-like LS8 cells by downregulation of phosphatidylinositol 3 kinase /protein kinase B pathway., PMID:31634727
Pseudogene Associated Recurrent Gene Fusion in Prostate Cancer., PMID:31446281
Mapping the Tooth Enamel Proteome and Amelogenin Phosphorylation Onto Mineralizing Porcine Tooth Crowns., PMID:31417410
Crystal structure of the inhibitor-free form of the serine protease kallikrein-4., PMID:31397325
A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases., PMID:31391482
MicroRNA-378-3p/5p suppresses the migration and invasiveness of oral squamous carcinoma cells by inhibiting KLK4 expression., PMID:31265790
Porcine keratin 75 in developing enamel., PMID:31252053
Increased fibrinolysis-induced bradykinin formation in hereditary angioedema confirmed using stored plasma and biotechnological inhibitors., PMID:31133046
KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors., PMID:31058493
Long non-coding RNA LINC01314 represses cell migration, invasion, and angiogenesis in gastric cancer via the Wnt/β-catenin signaling pathway by down-regulating KLK4., PMID:31007611
Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis., PMID:30945557
Potential function of TGF-β isoforms in maturation-stage ameloblasts., PMID:30929801
Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients., PMID:30811511
Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes., PMID:30644845
Reducing unnecessary biopsies while detecting clinically significant prostate cancer including cribriform growth with the ERSPC Rotterdam risk calculator and 4Kscore., PMID:30528698
Kallikrein-related peptidases 4, 5, 6 and 7 regulate tumour-associated factors in serous ovarian cancer., PMID:30287916
Constitutive activation of β-catenin in ameloblasts leads to incisor enamel hypomineralization., PMID:30066216
For research use only. Not for human or drug use.
