Catalog No.
YHK02801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe238-Ser395
Predicted molecular weight
21.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y259
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CKEKB, EKB, CHKL, EK, CHETK, CHKB, Choline/ethanolamine kinase, Choline kinase beta, Ethanolamine kinase, Choline kinase-like protein, CK, CKB, choline/ethanolamine kinase beta, Ethanolamine kinase beta
Immune-Mediated Megaconial Myopathy: A Novel Subtype of Autoimmune Myopathy., PMID:39475687
A rare homozygous variant of CHKB induced severe cardiomyopathy and a cardiac conduction disorder: a case report., PMID:39465137
Megaconial congenital muscular dystrophy: Importance of cutaneous features and successful response to ustekinumab., PMID:39143029
Exome sequencing reveals neurodevelopmental genes in simplex consanguineous Iranian families with syndromic autism., PMID:39103847
Phenotype-genotype spectrum of a cohort of congenital muscular dystrophies: a single-centre experience from India., PMID:39103709
Defects in integrin complex formation promote CHKB-mediated muscular dystrophy., PMID:38749543
CHKB-DT: A Long Noncoding RNA Critical for Cardiovascular Health., PMID:38359100
LncRNA CHKB-DT Downregulation Enhances Dilated Cardiomyopathy Through ALDH2., PMID:38299365
CHKB-AS1 enhances proliferation and resistance to NVP-BEZ235 of renal cancer cells via regulating the phosphorylation of MAP4 and PI3K/AKT/mTOR signaling., PMID:38093375
Skin biopsy findings in megaconial congenital muscular dystrophy with psoriasiform lesions due to variants in CHKB., PMID:37907281
Megaconial congenital muscular dystrophy due to CHKB gene variants, the first report of thirteen Iranian patients., PMID:37393748
Chronic Kidney Disease Transdifferentiates Veins into a Specialized Immune-Endocrine Organ with Increased MYCN-AP1 Signaling., PMID:37296603
Large heterozygous deletion and uniparental disomy masquerading as homozygosity in CHKB gene., PMID:36896673
Transcriptome-wide association study identifies novel genes associated with bone mineral density and lean body mass in children., PMID:36572794
Construction of a novel choline metabolism-related signature to predict prognosis, immune landscape, and chemotherapy response in colon adenocarcinoma., PMID:36451813
Megaconial congenital muscular dystrophy due to novel CHKB variants: a case report and literature review., PMID:36175989
Bi-allelic variants in CHKA cause a neurodevelopmental disorder with epilepsy and microcephaly., PMID:35202461
Mitochondrial Dynamics and Mitochondria-Lysosome Contacts in Neurogenetic Diseases., PMID:35177962
Reduced mitochondrial fission and impaired energy metabolism in human primary skeletal muscle cells of Megaconial Congenital Muscular Dystrophy., PMID:34518586
Histopathology is required to identify and characterize myopathies in high-throughput phenotype screening of genetically engineered mice., PMID:34269122
Screening of tumor grade-related mRNAs and lncRNAs for Esophagus Squamous Cell Carcinoma., PMID:33960436
Megaconial congenital muscular dystrophy secondary to novel CHKB mutations resemble atypical Rett syndrome., PMID:33712684
Genetic diseases of the Kennedy pathways for membrane synthesis., PMID:33454021
Emergent Coordination of the CHKB and CPT1B Genes in Eutherian Mammals: Implications for the Origin of Brown Adipose Tissue., PMID:33058877
Acupuncture alleviates chronic pain and comorbid conditions in a mouse model of neuropathic pain: the involvement of DNA methylation in the prefrontal cortex., PMID:32796318
Megaconial congenital muscular dystrophy: Same novel homozygous mutation in CHKB gene in two unrelated Chinese patients., PMID:31926838
Alteration of mitochondrial membrane inner potential in three Italian patients with megaconial congenital muscular dystrophy carrying new mutations in CHKB gene., PMID:30986505
Methionine and choline supply alter transmethylation, transsulfuration, and cytidine 5'-diphosphocholine pathways to different extents in isolated primary liver cells from dairy cows., PMID:30316602
[Treatment of choline kinase beta deficiency with citicoline]., PMID:29923598
Molecular structure and differential function of choline kinases CHKα and CHKβ in musculoskeletal system and cancer., PMID:27769579
A milder phenotype of megaconial congenital muscular dystrophy due to a novel CHKB mutation., PMID:27169979
Importance of Skin Changes in the Differential Diagnosis of Congenital Muscular Dystrophies., PMID:27123443
Megaconial muscular dystrophy caused by mitochondrial membrane homeostasis defect, new insights from skeletal and heart muscle analyses., PMID:26855408
Proximal myopathy with focal depletion of mitochondria and megaconial congenital muscular dystrophy are allelic conditions caused by mutations in CHKB., PMID:26782016
Choline Kinase Beta-Related Muscular Dystrophy, Appearance of Muscle Involvement on Magnetic Resonance Imaging., PMID:26548592
Clinical characteristics of megaconial congenital muscular dystrophy due to choline kinase beta gene defects in a series of 15 patients., PMID:26067811
Congenital neurogenic muscular atrophy in megaconial myopathy due to a mutation in CHKB gene., PMID:26006750
New splicing mutation in the choline kinase beta (CHKB) gene causing a muscular dystrophy detected by whole-exome sequencing., PMID:25740612
Ets and GATA transcription factors play a critical role in PMA-mediated repression of the ckβ promoter via the protein kinase C signaling pathway., PMID:25490397
Novel CHKB mutation expands the megaconial muscular dystrophy phenotype., PMID:25187204
Inborn errors of metabolism in the biosynthesis and remodelling of phospholipids., PMID:25178427
Exome sequencing identifies a CHKB mutation in Spanish patient with megaconial congenital muscular dystrophy and mtDNA depletion., PMID:24997086
Identification of the variations in the CPT1B and CHKB genes along with the HLA-DQB1*06:02 allele in Turkish narcolepsy patients and healthy persons., PMID:24571861
[New congenital muscular dystrophy due to CHKB mutations]., PMID:24291895
Megaconial congenital muscular dystrophy due to loss-of-function mutations in choline kinase β., PMID:23945283
Variants in phospholipid metabolism and upstream regulators and non-small cell lung cancer susceptibility., PMID:23896864
Muscular dystrophy with large mitochondria associated with mutations in the CHKB gene in three British patients: extending the clinical and pathological phenotype., PMID:23692895
Phelan-McDermid syndrome: clinical report of a 70-year-old woman., PMID:23166010
Congenital megaconial myopathy due to a novel defect in the choline kinase Beta gene., PMID:22782513
For research use only. Not for human or drug use.
