Catalog No.
YHK02001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg210
Predicted molecular weight
25.45 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H165
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
B-cell CLL/lymphoma 11A, EVI-9, CTIP1, EVI9, Zinc finger protein 856, KIAA1809, B-cell lymphoma/leukemia 11A, COUP-TF-interacting protein 1, Ecotropic viral integration site 9 protein homolog, ZNF856, BCL11A, BCL-11A
Spatial profiling of chromatin accessibility reveals alteration of glial cells in Alzheimer's disease mouse brain., PMID:40501718
Upregulation of miR-17-3p is associated with HbF in patients with β-thalassemia and induces γ-globin expression by targeting BCL11A., PMID:40448206
Genetic polymorphism of novel SNP rs5006884 in OR51B6 and SNP rs4499252 in AHSP among transfusion-dependent and non-transfusion-dependent β-thalassemia/Hb E patients in Thailand: a multivariate analysis of clinical and genetic polymorphism., PMID:40377674
A multiomic analysis of Waldenström macroglobulinemia defines distinct disease subtypes., PMID:40332467
CHD8 interacts with BCL11A to induce oncogenic transcription in triple negative breast cancer., PMID:40328966
Hydroxyurea reduces the levels of the fetal globin gene repressors ZBTB7A/LRF and BCL11A in erythroid cells in vitro., PMID:40304012
Decoding HbF reactivation by hydroxyurea in hemoglobinopathy patients through microRNA signatures., PMID:40278921
Multimeric transcription factor BCL11A utilizes two zinc-finger tandem arrays to bind clustered short sequence motifs., PMID:40246927
Bcl11a maintains hematopoietic stem cell function but accelerates inflammation-driven exhaustion during aging., PMID:40215324
Development of Polygenic Risk Score for Persistent Albuminuria in Children and Adults With Sickle Cell Anemia., PMID:40186439
Solution structure of the Z0 domain from transcription repressor BCL11A sheds light on the sequence properties of protein-binding zinc fingers., PMID:40099876
A critique review of fetal hemoglobin modulators through targeting epigenetic regulators for the treatment of sickle cell disease., PMID:40057227
FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestries., PMID:40025045
BCL11A-deficient human erythropoiesis is impaired in vitro and after xenotransplantation into mice., PMID:40020162
Rapid detection of genetic modifiers of β-thalassemia based on MALDI-TOF MS., PMID:40016399
Exploratory Review and In Silico Insights into circRNA and RNA-Binding Protein Roles in γ-Globin to β-Globin Switching., PMID:39996784
Utility of Optical Genome Mapping for Accurate Detection and Fine-Mapping of Structural Variants in Elusive Rare Diseases., PMID:39941010
A replication study of novel fetal hemoglobin-associated genetic variants in sickle cell disease-only cohorts., PMID:39886999
The Effect of Single Nucleotide Polymorphisms on Clinical Phenotypes of Sabahan Transfusion-Dependent β-Thalassemia Patients with Homozygous Filipino β0-Deletion., PMID:39806862
CRISPR/Cas9 System as a Promising Therapy in Thalassemia and Sickle Cell Disease: A Systematic Review of Clinical Trials., PMID:39794549
Enhanced fetal hemoglobin production via dual-beneficial mutation editing of the HBG promoter in hematopoietic stem and progenitor cells for β-hemoglobinopathies., PMID:39736768
Direct delivery of Cas-embedded cytosine base editors as ribonucleoprotein complexes for efficient and accurate editing of clinically relevant targets., PMID:39676659
Redirecting E3 ubiquitin ligases for targeted protein degradation with heterologous recognition domains., PMID:39675716
Gene editing without ex vivo culture evades genotoxicity in human hematopoietic stem cells., PMID:39672163
The role of miR-129-5p in regulating γ-globin expression and erythropoiesis in β-thalassemia., PMID:39657657
BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate., PMID:39642886
A finger that gets in the way: When binding isn't just about the bound state., PMID:39642848
A catalog of gene editing sites and genetic variations in editing sites in model organisms., PMID:39614172
A tetramer of BCL11A is required for stable protein production and fetal hemoglobin silencing., PMID:39607926
BCL11A expression worsens the prognosis of DLBCL and its co-expression with C-MYC predicts poor survival., PMID:39546996
CRISPR-based gene therapy for the induction of fetal hemoglobin in sickle cell disease., PMID:39535263
Genetic Polymorphisms Associated with Fetal Hemoglobin (HbF) Levels and F-Cell Numbers: A Systematic Review of Genome-Wide Association Studies., PMID:39518961
Identification of small molecule agonists of fetal hemoglobin expression for the treatment of sickle cell disease., PMID:39504332
A mutant BCL11B-N440K protein interferes with BCL11A function during T lymphocyte and neuronal development., PMID:39487351
Upregulation of miR‑6747‑3p affects red blood cell lineage development and induces fetal hemoglobin expression by targeting BCL11A in β‑thalassemia., PMID:39450557
BCL11A intellectual developmental disorder: defining the clinical spectrum and genotype-phenotype correlations., PMID:39448799
Conserved helical motifs in the IKZF1 disordered region mediate NuRD interaction and transcriptional repression., PMID:39437550
Distinct deregulation trends of transcriptional protein complexes in aging naive T cells., PMID:39437255
Structural insights into the DNA-binding mechanism of BCL11A: The integral role of ZnF6., PMID:39423807
Zinc finger nuclease-mediated gene editing in hematopoietic stem cells results in reactivation of fetal hemoglobin in sickle cell disease., PMID:39414860
Hepatoid thymic carcinoma in a polycythemia vera patient treated with ropeginterferon Alfa-2b: Clinical, histopathological and molecular correlates., PMID:39405803
TR4 and BCL11A repress γ-globin transcription via independent mechanisms., PMID:39393056
The BCL11A transcription factor stimulates the enzymatic activities of the OGG1 DNA glycosylase., PMID:39272221
Mitochondrial ATP Synthesis and Proton Transport Synergistically Mitigate Oligodendrocyte Progenitor Cell Dysfunction Following Transient Middle Cerebral Artery Occlusion via the Pbx3/Dguok/Kif21b Signaling Pathway., PMID:39239553
[Genetic analysis of a child with Dias-Logan syndrome due to variant of BCL11A gene]., PMID:39217489
Identification of genetic variants associated with clinical features of sickle cell disease., PMID:39209956
Identification of novel BCL11A variant in a patient with developmental delay and behavioural differences., PMID:39187446
A Review of Gene Therapies for Hemoglobinopathies., PMID:39145521
The glucocorticoid receptor elicited proliferative response in human erythropoiesis is BCL11A-dependent., PMID:39110040
Development and IND-enabling studies of a novel Cas9 genome-edited autologous CD34+ cell therapy to induce fetal hemoglobin for sickle cell disease., PMID:39086133
For research use only. Not for human or drug use.
