Catalog No.
YHK01501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val155-Phe471
Predicted molecular weight
38.75 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UK99
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FBX3, FBXO3, F-box only protein 3
Structural Insight Into the SKP1-CUL1-FBXO3-RBX1 Complex., PMID:39921442
Activation of lysophagy by a TBK1-SCFFBXO3-TMEM192-TAX1BP1 axis in response to lysosomal damage., PMID:39875384
Identification of a gene controlling levels of the copper response regulator 1 transcription factor in Chlamydomonas reinhardtii., PMID:39777451
Distinct Regions within SAP25 Recruit O-Linked Glycosylation, DNA Demethylation, and Ubiquitin Ligase and Hydrolase Activities to the Sin3/HDAC Complex., PMID:39435885
Rift Valley fever virus coordinates the assembly of a programmable E3 ligase to promote viral replication., PMID:39366381
The Transcription Factor Tbx5-Dependent Epigenetic Modification Contributes to Neuropathic Allodynia by Activating TRPV1 Expression in the Dorsal Horn., PMID:39174351
The COP9 signalosome stabilized MALT1 promotes Non-Small Cell Lung Cancer progression through activation of NF-κB pathway., PMID:38864940
Ginsenoside Rg1 Alleviates Sepsis-Induced Acute Lung Injury by Reducing FBXO3 Stability in an m6A-Dependent Manner to Activate PGC-1α/Nrf2 Signaling Pathway., PMID:38622374
Mutation of negative regulatory gene CEHC1 encoding an FBXO3 protein results in normoxic expression of HYDA genes in Chlamydomonas reinhardtii., PMID:38586028
Distinct regions within SAP25 recruit O-linked glycosylation, DNA demethylation, and ubiquitin ligase and hydrolase activities to the Sin3/HDAC complex., PMID:38496433
FBXO3 stabilizes USP4 and Twist1 to promote PI3K-mediated breast cancer metastasis., PMID:38134227
BC-1215 inhibits ATP-induced IL-1β secretion via the FBXL2-mediated ubiquitination and degradation of not only NLRP3, but also pro-IL-1β in LPS-primed THP-1 cells., PMID:37004285
E3 Ubiquitin Ligase FBXO3 Drives Neuroinflammation to Aggravate Cerebral Ischemia/Reperfusion Injury., PMID:36362432
Cross-Regulation of F-Box Protein FBXL2 with T-bet and TNF-α during Acute and Chronic Lung Allograft Rejection., PMID:36113884
miR-219a-5p inhibits the pyroptosis in knee osteoarthritis by inactivating the NLRP3 signaling via targeting FBXO3., PMID:35962723
Diverse Roles of F-BoxProtein3 in Regulation of Various Cellular Functions., PMID:35127719
Differential Gene Expression in Host Ubiquitination Processes in Childhood Malarial Anemia., PMID:34880904
Correction: Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7., PMID:34261669
Phosphorylation regulates cullin-based ubiquitination in tumorigenesis., PMID:33643814
Noncanonical TGF-β signaling leads to FBXO3-mediated degradation of ΔNp63α promoting breast cancer metastasis and poor clinical prognosis., PMID:33626035
Blocking the Spinal Fbxo3/CARM1/K+ Channel Epigenetic Silencing Pathway as a Strategy for Neuropathic Pain Relief., PMID:33415686
Correction: Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7., PMID:33277389
Gene expression in the epileptic (EL) mouse hippocampus., PMID:33153970
Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7., PMID:32859728
MiR-142-3p Attenuates Oxygen Glucose Deprivation/Reoxygenation-Induced Injury by Targeting FBXO3 in Human Neuroblastoma SH-SY5Y Cells., PMID:31863884
Targeting F-Box Protein Fbxo3 Attenuates Lung Injury Induced by Ischemia-Reperfusion in Rats., PMID:31178737
The SCFFBXO3 ubiquitin E3 ligase regulates inflammation in atherosclerosis., PMID:30448480
Ex vivo lung perfusion as a human platform for preclinical small molecule testing., PMID:30282819
Absence of CD59 in Guinea Pigs: Analysis of the Cavia porcellus Genome Suggests the Evolution of a CD59 Pseudogene., PMID:29167230
Belinostat exerts antitumor cytotoxicity through the ubiquitin-proteasome pathway in lung squamous cell carcinoma., PMID:28397399
Spinal Fbxo3-Dependent Fbxl2 Ubiquitination of Active Zone Protein RIM1α Mediates Neuropathic Allodynia through CaV2.2 Activation., PMID:27629721
FBXO3 Protein Promotes Ubiquitylation and Transcriptional Activity of AIRE (Autoimmune Regulator)., PMID:27365398
Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients With Missense AIP Mutations., PMID:27253664
Crystal structure and interaction studies of the human FBxo3 ApaG domain., PMID:27010866
Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade., PMID:26674878
Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2 E3 Ligase., PMID:26037928
F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation., PMID:25721664
Proteomic analyses uncover a new function and mode of action for mouse homolog of Diaphanous 2 (mDia2)., PMID:25682332
Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH., PMID:24403578
Targeting F box protein Fbxo3 to control cytokine-driven inflammation., PMID:24123678
A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation., PMID:23542741
A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems., PMID:21306995
PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation., PMID:18809579
For research use only. Not for human or drug use.
