Catalog No.
YHK01201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asp248
Predicted molecular weight
30.46 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UL15
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BAG5, KIAA0873, BAG-5, BAG family molecular chaperone regulator 5, Bcl-2-associated athanogene 5
Polydatin reactivates mitochondrial bioenergetics and mitophagy while preventing premature senescence by modulating microRNA-155 and its direct targets in human fibroblasts with trisomy 21., PMID:40280316
Mendelian randomization of plasma proteomics identifies novel ALS-associated proteins and their GO enrichment and KEGG pathway analyses., PMID:40033250
Male germ cells with Bag5 deficiency show reduced spermiogenesis and exchange of basic nuclear proteins., PMID:39992433
Beta-amyloid protein regulates miR-15a and activates Bag5 to influence neuronal apoptosis in Alzheimer's disease., PMID:39788499
Integrated hormone and transcriptome profiles provide insight into the pericarp differential development mechanism between Mandarin 'Shatangju' and 'Chunhongtangju'., PMID:39450074
A novel BAG5 variant impairs the ER stress response pathway, causing dilated cardiomyopathy and arrhythmia., PMID:38796549
Arabidopsis BECLIN1-induced autophagy mediates reprogramming in tapetal programmed cell death by altering the gross cellular homeostasis., PMID:38503186
BAG5 regulates HSPA8-mediated protein folding required for sperm head-tail coupling apparatus assembly., PMID:38454159
Akt Is Controlled by Bag5 through a Monoubiquitination to Polyubiquitination Switch., PMID:38139359
Drought-responsive genes in tomato: meta-analysis of gene expression using machine learning., PMID:37938584
Human proteins curing yeast prions., PMID:37903258
Compound Heterozygous Truncating Variants in the BAG5 Gene As a Cause of Early-Onset Dilated Cardiomyopathy., PMID:37873655
Identification of candidate mitochondrial inheritance determinants using the mammalian cell-free system., PMID:37470242
LncRNA TUG1 Promoted Stabilization of BAG5 by Binding DDX3X to Exacerbate Ketamine-Induced Neurotoxicity., PMID:36151390
Refractory Ventricular Arrhythmias in a Patient With Dilated Cardiomyopathy Caused by a Nonsense Mutation in BAG5., PMID:36130910
Identification of BAG5 as a Potential Biomarker for Parkinson's Disease Patients With R492X PINK1 Mutation., PMID:35968372
Role of BAG5 in Protein Quality Control: Double-Edged Sword?, PMID:35821856
Apoptosis-related genes-based prognostic signature for osteosarcoma., PMID:35504036
Chaperone protein BAG5 provides more than just an escort service., PMID:39195993
Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation., PMID:35044787
Unraveling the role of tomato Bcl-2-associated athanogene (BAG) proteins during abiotic stress response and fruit ripening., PMID:34741097
miR-142-5p regulates lipopolysaccharide-induced bovine epithelial cell proliferation and apoptosis via targeting BAG5., PMID:34707706
Lipoxin A4 methyl ester protects PC12 cells from ketamine-induced neurotoxicity via the miR-22/BAG5 pathway., PMID:34670429
RNA-Seq analysis reveals potential regulators of programmed cell death and leaf remodelling in lace plant (Aponogeton madagascariensis)., PMID:34388962
Implication of BAG5 downregulation in metabolic reprogramming of cisplatin-resistant ovarian cancer cells via mTORC2 signaling pathway., PMID:34126157
Circ_0008305-mediated miR-660/BAG5 axis contributes to hepatocellular carcinoma tumorigenesis., PMID:33481351
Tumor Mutational Burden Is Polygenic and Genetically Associated with Complex Traits and Diseases., PMID:33419773
MiRNA-429 alleviates ketamine-induced neurotoxicity through targeting BAG5., PMID:33283947
PRMT6 deficiency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability., PMID:33186656
Identification of BAG5 from orange-spotted grouper (Epinephelus coioides) involved in viral infection., PMID:33137395
Stress-induced p53 drives BAG5 cochaperone expression to control α-synuclein aggregation in Parkinson's disease., PMID:33085644
Investigating the Transition of Pre-Symptomatic to Symptomatic Huntington's Disease Status Based on Omics Data., PMID:33049985
A Mouse Brain-based Multi-omics Integrative Approach Reveals Potential Blood Biomarkers for Ischemic Stroke., PMID:32868372
BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62., PMID:32850835
Bcl-2-associated athanogene 5 overexpression attenuates catecholamine-induced vascular endothelial cell apoptosis., PMID:32583430
Uncovering Potential Roles of Differentially Expressed Genes, Upstream Regulators, and Canonical Pathways in Endometriosis Using an In Silico Genomics Approach., PMID:32575462
Signals from the Metastatic Niche Regulate Early and Advanced Ovarian Cancer Metastasis through miR-4454 Downregulation., PMID:32350057
BAG5 promotes invasion of papillary thyroid cancer cells via upregulation of fibronectin 1 at the translational level., PMID:32275930
Systems Genetics of Optic Nerve Axon Necrosis During Glaucoma., PMID:32174956
Profiling haplotype specific CpG and CpH methylation within a schizophrenia GWAS locus on chromosome 14 in schizophrenia and healthy subjects., PMID:32170143
miR-155 inhibits mitophagy through suppression of BAG5, a partner protein of PINK1., PMID:31948758
miR‑155 inhibition represents a potential valuable regulator in mitigating myocardial hypoxia/reoxygenation injury through targeting BAG5 and MAPK/JNK signaling., PMID:31922242
Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death., PMID:31787745
Dissociation of mitochondrial HK-II elicits mitophagy and confers cardioprotection against ischemia., PMID:31570704
Molecular and Cellular Mechanisms of Apoptosis during Dissociated Spermatogenesis., PMID:28424629
[Analysis of gene expression pattern in peripheral blood leukocytes during experimental heat wave]., PMID:28414285
A plant Bcl-2-associated athanogene is proteolytically activated to confer fungal resistance., PMID:28358147
BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage., PMID:28348719
A novel mutant p53 binding partner BAG5 stabilizes mutant p53 and promotes mutant p53 GOFs in tumorigenesis., PMID:27807478
MicroRNA-127-3p acts as a tumor suppressor in epithelial ovarian cancer by regulating the BAG5 gene., PMID:27571744
For research use only. Not for human or drug use.
