Catalog No.
YHK00901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly247-Gln496
Predicted molecular weight
30.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q5JPH6
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA1970, Glutamyl-tRNA synthetase, EARS2, Probable glutamate--tRNA ligase, mitochondrial, GluRS
B cell dysfunction in thalamus and brainstem involvement and high lactate caused by novel mutation of EARS2 gene., PMID:40389993
Identification of EARS2 as a Potential Biomarker with Diagnostic, Prognostic, and Therapeutic Implications in Colorectal Cancer., PMID:39906030
Phenotyping mitochondrial glutamyl-tRNA synthetase deficiency (EARS2): A case series and systematic literature review., PMID:39173847
Proteomic-based stratification of intermediate-risk prostate cancer patients., PMID:38052461
Mitochondrial aminoacyl-tRNA synthetases trigger unique compensatory mechanisms in neurons., PMID:37975900
Neuropathological hallmarks of antenatal mitochondrial diseases with a corpus callosum defect., PMID:36349561
EARS2 significantly coexpresses with PALB2 in breast and pancreatic cancer., PMID:35779338
The Landscape of Aminoacyl-tRNA Synthetases Involved in Severe Acute Respiratory Syndrome Coronavirus 2 Infection., PMID:35153822
Phenotypic diversity of brain MRI patterns in mitochondrial aminoacyl-tRNA synthetase mutations., PMID:33972171
Remitting and exacerbating white matter lesions in leukoencephalopathy with thalamus and brainstem involvement and high lactate., PMID:33962821
Identification of Metabolic-Associated Genes for the Prediction of Colon and Rectal Adenocarcinoma., PMID:33833525
Metabolic shift underlies recovery in reversible infantile respiratory chain deficiency., PMID:33128823
Identification of a Novel Variant in EARS2 Associated with a Severe Clinical Phenotype Expands the Clinical Spectrum of LTBL., PMID:32887222
Roles of BdUNICULME4 and BdLAXATUM-A in the non-domesticated grass Brachypodium distachyon., PMID:32343459
Mutations in aARS genes revealed by targeted next-generation sequencing in patients with mitochondrial diseases., PMID:32319008
Phenotypes and genotypes of mitochondrial aminoacyl-tRNA synthetase deficiencies from a single neurometabolic clinic., PMID:32071833
Mitochondrial aminoacyl-tRNA synthetase disorders: an emerging group of developmental disorders of myelination., PMID:31839000
The genomic and clinical landscape of fetal akinesia., PMID:31680123
Clinical and molecular characteristics of newly reported mitochondrial disease entity caused by biallelic PARS2 mutations., PMID:29410512
Functionally pathogenic EARS2 variants in vitro may not manifest a phenotype in vivo., PMID:28748214
Severe Metabolic Acidosis and Hepatopathy due to Leukoencephalopathy with Thalamus and Brainstem Involvement and High Lactate., PMID:27875839
Lethal Neonatal LTBL Associated with Biallelic EARS2 Variants: Case Report and Review of the Reported Neuroradiological Features., PMID:27571996
Leukoencephalopathy with thalamus and brainstem involvement and high lactate caused by novel mutations in the EARS2 gene in two siblings., PMID:27206875
A compound heterozygous EARS2 mutation associated with mild leukoencephalopathy with thalamus and brainstem involvement and high lactate (LTBL)., PMID:27117034
Early-Onset Mild Type Leukoencephalopathy Caused by a Homozygous EARS2 Mutation., PMID:26893310
EARS2 mutations cause fatal neonatal lactic acidosis, recurrent hypoglycemia and agenesis of corpus callosum., PMID:26780086
Leukoencephalopathy with thalamus and brainstem involvement and high lactate 'LTBL' caused by EARS2 mutations., PMID:22492562
For research use only. Not for human or drug use.
