Catalog No.
YHK00701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala393-Met697
Predicted molecular weight
36.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UKU0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ACSL6, ACS2, Long-chain-fatty-acid--CoA ligase 6, Arachidonate--CoA ligase, LACS 6, KIAA0837, FACL6, Long-chain acyl-CoA synthetase 6, LACS5
Ferroptosis and necroptosis may be involved in the formation and progression of hydrofluoric acid burn wounds: Results from an RNA-Seq analysis., PMID:40327971
Imatinib-Induced Clinical Response in ETV6::ACSL6 Myeloid Neoplasm with Eosinophilic Pneumonitis: A Case Report., PMID:40200571
ACSL6-Mediated Cell Ferroptosis by Inhibiting AMPK Pathway in Periodontitis Stem Cells., PMID:40116099
Transcriptomic profiling identifies ferroptosis and NF-κB signaling involved in α-dimorphecolic acid regulation of microglial inflammation., PMID:40038710
Transcriptomic analysis of broiler chickens reveals metabolic adaptations to a reduced crude protein diet., PMID:39983527
Variations in rumen microbiota and host genome impacted feed efficiency in goat breeds., PMID:39944650
Construction and Validation of a Novel Butyrylation-Related Gene Signature Related to Prognosis, Clinical Implications, and Immune Microenvironment Characterization of Hepatocellular Carcinoma., PMID:39926543
Bioinformatics insights into ACSL1 and ACSL5: prognostic and immune roles in low-grade glioma., PMID:39924494
Novel ETV6::RAPGEF6 fusion gene in chronic eosinophilic leukemia: compiling evidence on the role of IL3 overexpression in tumorigenesis., PMID:39923209
(-)-Epigallocatechin-3-O-Gallate Regulates Muscle Growth, Antioxidant Status, and Nutritional Composition of Juvenile Common Carp (Cyprinus carpio L.)., PMID:39555542
Ozone-Induced Lung Injury are Mediated Via PPAR-Mediated Ferroptosis in Mice., PMID:39370454
ACSL6-activated IL-18R1-NF-κB promotes IL-18-mediated tumor immune evasion and tumor progression., PMID:39292786
Acyl-CoA Synthetase Long-Chain Isoenzymes in Kidney Diseases: Mechanistic Insights and Therapeutic Implications., PMID:39210707
Blocking ACSL6 Compromises Autophagy via FLI1-Mediated Downregulation of COLs to Radiosensitize Lung Cancer., PMID:39206814
Acyl-CoA synthetase 6 controls rod photoreceptor function and survival by shaping the phospholipid composition of retinal membranes., PMID:39169121
ETV6::ACSL6 translocation-driven super-enhancer activation leads to eosinophilia in acute lymphoblastic leukemia through IL-3 overexpression., PMID:38356460
Increased ACSL6 Expression Predicts a Favorable Prognosis in Triple-negative Breast Cancer., PMID:38310395
Integrative bioinformatics analysis of ACS enzymes as candidate prognostic and diagnostic biomarkers in colon adenocarcinoma., PMID:37614614
Long chain acyl-CoA synthetase 6 facilitates the local distribution of di-docosahexaenoic acid- and ultra-long-chain-PUFA-containing phospholipids in the retina to support normal visual function in mice., PMID:37585289
GPX4 is a key ferroptosis biomarker and correlated with immune cell populations and immune checkpoints in childhood sepsis., PMID:37443372
Description of an Institutional Cohort of Myeloid Neoplasms Carrying ETV6-Locus Deletions or ETV6 Rearrangements., PMID:36848872
Lipid metabolism in dopaminergic neurons influences light entrainment., PMID:36815399
Prognostic Role of Long-Chain Acyl-Coenzyme A Synthetase Family Genes in Patients with Clear Cell Renal Cell Carcinoma: A Comprehensive Bioinformatics Analysis Confirmed with External Validation Cohorts., PMID:36529627
A Bioinformatics Perspective on the Dysregulation of Ferroptosis and Ferroptosis-related Immune Cell Infiltration in Alzheimer's Disease., PMID:36438927
Transcriptomic analysis of the thyroid and ovarian stroma reveals key pathways and potential candidate genes associated with egg production in ducks., PMID:36435165
ETV6::ACSL6 fusion gene in myeloid malignancies with eosinophilia: a report of two cases with t(5;12) or normal karyotype., PMID:36315405
A ferroptosis associated gene signature for predicting prognosis and immune responses in patients with colorectal carcinoma., PMID:36160009
Myeloid neoplasm with ETV6::ACSl6 fusion: landscape of molecular and clinical features., PMID:36069745
[Mining of Differentially Expressed Genes in Diabetic Cardiomyopathy Based on GEO Database]., PMID:36065685
Ectopic Acsl6 Overexpression Partially Improves Isoproterenol-Induced Cardiac Hypertrophy In Vivo and Cardiomyocyte Hypertrophy In Vitro., PMID:35976155
Sex differences in heart mitochondria regulate diastolic dysfunction., PMID:35787630
Novel Variation in Acyl-CoA Synthetase Long Chain Family Member 6 (ACSL6) Results in Protein Structural Modification and Multiple Non-Related Neoplasia in a 46-Year-Old: Case Report., PMID:35756649
t(5;12)(q31;p13)/ETV6::ACSL6 and t(6;9)(p23;q34)/DEK::NUP214 concurrence in acute myeloid leukemia: an unusual association of two rare abnormalities., PMID:34979355
Substrate Specificity of Human Long-Chain Acyl-CoA Synthetase ACSL6 Variants., PMID:34602568
ACSL family: The regulatory mechanisms and therapeutic implications in cancer., PMID:34332918
Targeted RNA sequencing in the routine clinical detection of fusion genes in salivary gland tumors., PMID:34176176
Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging., PMID:34100386
APOE4 genotype exacerbates the impact of menopause on cognition and synaptic plasticity in APOE-TR mice., PMID:33891334
Evolution, expression profile, and regulatory characteristics of ACSL gene family in chicken (Gallus gallus)., PMID:32860898
Skeletal Muscle ACSL Isoforms Relate to Measures of Fat Metabolism in Humans., PMID:32796254
Molecular Cloning, Characterization, and Expression Regulation of Acyl-CoA Synthetase 6 Gene and Promoter in Common Carp Cyprinus carpio., PMID:32635148
Suppression of long chain acyl-CoA synthetase blocks intracellular fatty acid flux and glucose uptake in skeletal myotubes., PMID:32126286
Acyl-CoA synthetase 6 regulates long-chain polyunsaturated fatty acid composition of membrane phospholipids in spermatids and supports normal spermatogenic processes in mice., PMID:31648559
Diet and Exercise Training Influence Skeletal Muscle Long-Chain acyl-CoA Synthetases., PMID:31524824
Acyl-CoA synthetase 6 enriches seminiferous tubules with the ω-3 fatty acid docosahexaenoic acid and is required for male fertility in the mouse., PMID:31399511
Idi1 and Hmgcs2 Are Affected by Stretch in HL-1 Atrial Myocytes., PMID:30567295
Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain., PMID:30401738
Identification of Critical Genes and Five Prognostic Biomarkers Associated with Colorectal Cancer., PMID:29973580
The lncRNA, Nespas, Is Associated with Osteoarthritis Progression and Serves as a Potential New Prognostic Biomarker., PMID:28805067
Association of long-chain acyl-coenzyme A synthetase 5 expression in human breast cancer by estrogen receptor status and its clinical significance., PMID:28498416
For research use only. Not for human or drug use.
