Catalog No.
YHK00601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg22-Gln168
Predicted molecular weight
19.28 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H772
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DAN domain family member 3, DAND3, CKTSF1B2, GREM2, Protein related to DAN and cerberus, Cysteine knot superfamily 1, BMP antagonist 2, PRDC, Gremlin-2
Overexpression of miR-671-3p alleviates postmenopausal osteoporosis by targeting GREM2 to activate BMP2/SMAD signaling pathway., PMID:40500779
Genetic Aspects of Tooth Agenesis., PMID:40428404
Association Between Circulating Gremlin 2 and β-Cell Function Among Participants With Prediabetes and Type 2 Diabetes., PMID:40270326
ASXL1 truncating variants in BOS and myeloid leukemia drive shared disruption of Wnt-signaling pathways but have differential isoform usage of RUNX3., PMID:39614348
Gremlin-2 is a novel tumor suppressor that negatively regulates ID1 in breast cancer., PMID:39614338
BMP Antagonist Gremlin 2 Regulates Hippocampal Neurogenesis and Is Associated with Seizure Susceptibility and Anxiety., PMID:39349059
(+)-Catechins Play a Protective Role in Diabetic Kidney Disease by Alleviating EMT through Multiple Pathways., PMID:39121356
GREM2 inactivation increases trabecular bone mass in mice., PMID:38839844
Inhibition of BMP signaling pathway induced senescence and calcification in anaplastic meningioma., PMID:38446374
The inhibitory effect of Gremlin-2 on adipogenesis suppresses breast cancer cell growth and metastasis., PMID:37880751
Mild dehydration effects on the murine kidney single-nucleus transcriptome and chromatin accessibility., PMID:37767569
Mobilisation of jerboa kidney gene networks during dehydration and opportunistic rehydration., PMID:37664605
The Impact of Genetic Variability of TGF-Beta Signaling Biomarkers in Major Craniofacial Syndromes., PMID:37525043
SGLT2 inhibitor empagliflozin downregulates miRNA-34a-5p and targets GREM2 to inactivate hepatic stellate cells and ameliorate non-alcoholic fatty liver disease-associated fibrosis., PMID:37422021
Integrated analysis of genome-wide gene expression and DNA methylation profiles reveals candidate genes in ovary endometriosis., PMID:37033258
CircZFR promotes pancreatic cancer progression through a novel circRNA-miRNA-mRNA pathway and stabilizing epithelial-mesenchymal transition protein., PMID:36990335
Unveiling the transcriptomic landscape and the potential antagonist feedback mechanisms of TGF-β superfamily signaling module in bone and osteoporosis., PMID:36443839
Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype., PMID:36167601
Optimizing Tenogenic Differentiation of Equine Adipose-Derived Mesenchymal Stem Cells (eq-ASC) Using TGFB3 Along with BMP Antagonists., PMID:36043405
Selection signature analyses and genome-wide association reveal genomic hotspot regions that reflect differences between breeds of horse with contrasting risk of degenerative suspensory ligament desmitis., PMID:35866615
MiR-103a-3p Contributes to the Progression of Colorectal Cancer by Regulating GREM2 Expression., PMID:35619575
GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning., PMID:35349825
miR-122-5p targets GREM2 to protect against glucocorticoid-induced endothelial damage through the BMP signaling pathway., PMID:34973370
Evolution of the DAN gene family in vertebrates., PMID:34902310
Bone morphogenetic protein 2 inhibits growth differentiation factor 8-induced cell signaling via upregulation of gremlin2 expression in human granulosa-lutein cells., PMID:34838049
MicroRNA-23b-3p Deletion Induces an IgA Nephropathy-like Disease Associated with Dysregulated Mucosal IgA Synthesis., PMID:34479967
Distinguishing colorectal adenoma from hyperplastic polyp by WNT2 expression., PMID:34477243
Gremlin2 Activates Fibroblasts to Promote Pulmonary Fibrosis Through the Bone Morphogenic Protein Pathway., PMID:34422900
Deletion of Gremlin-2 alters estrous cyclicity and disrupts female fertility in mice†., PMID:34333627
Gremlin 2 suppresses differentiation of stem/progenitor cells in the human skin., PMID:34307797
LncRNA DNM3OS regulates GREM2 via miR-127-5p to suppress early chondrogenic differentiation of rat mesenchymal stem cells under hypoxic conditions., PMID:34049478
SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells., PMID:33506343
Functional characterization of ATF1, GREM2 AND WNT10B variants associated with tooth agenesis., PMID:33369218
Tooth agenesis: What do we know and is there a connection to cancer?, PMID:33249565
Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling pathway., PMID:33144675
Characterization of the different oligomeric states of the DAN family antagonists SOSTDC1 and SOST., PMID:32779697
Association of Gremlin-2 gene polymorphisms with osteoporosis risk in Chinese postmenopausal women., PMID:32297643
Genetic Dissection of Femoral and Tibial Microarchitecture., PMID:31844829
Neuronal specific and non-specific responses to cadmium possibly involved in neurodegeneration: A toxicogenomics study in a human neuronal cell model., PMID:31738976
Increase of gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis., PMID:31709279
GREM2 maintains stem cell-like phenotypes in gastric cancer cells by regulating the JNK signaling pathway., PMID:31345097
Gremlin is a potential target for posterior capsular opacification., PMID:31234714
Transcriptome signatures associated with meningioma progression., PMID:31039818
Genome-Wide Association and Functional Studies Reveal Novel Pharmacological Mechanisms for Allopurinol., PMID:30924126
Grem2 mediates podocyte apoptosis in high glucose milieu., PMID:30831151
Gremlin-1 and gremlin-2 levels in polycystic ovary syndrome and their clinical correlations., PMID:30712421
Gingival fibroblasts prevent BMP-mediated osteoblastic differentiation., PMID:30511378
Further evidence for the role of WNT10A, WNT10B and GREM2 as candidate genes for isolated tooth agenesis., PMID:30246922
Association betweenGREM2 gene polymorphism with osteoporosis and osteopenia in postmenopausal women., PMID:30014930
Genetic analysis: Wnt and other pathways in nonsyndromic tooth agenesis., PMID:29969831
For research use only. Not for human or drug use.
