Catalog No.
YHK00501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly366-Pro597
Predicted molecular weight
29.22 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UJX2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
APC8, Anaphase-promoting complex subunit 8, CDC23, Cell division cycle protein 23 homolog, Cyclosome subunit 8, ANAPC8
Liquid biopsy-derived extracellular vesicle protein biomarkers for diagnosis and prognostic assessment of lung squamous cell carcinoma., PMID:40275246
Infertile females with biallelic mutations in APC/C genes are characterized by oocyte or early embryo defects., PMID:40238067
Utility of a Large Series of B-Cell Precursor Acute Lymphoblastic Leukemia Cell Lines as a Model System., PMID:40022573
PATL2 mutations affect human oocyte maternal mRNA homeostasis and protein interactions in cell cycle regulation., PMID:39741299
RTEL1 is upregulated in gastric cancer and promotes tumor growth., PMID:39724284
Global A-to-I RNA editing during myogenic differentiation of goat MuSCs., PMID:39444736
Gene Expression Analysis of Yeast Strains with a Nonsense Mutation in the eRF3-Coding Gene Highlights Possible Mechanisms of Adaptation., PMID:38928012
High MCM6 expression promotes proliferation and correlates with poor prognosis in triple-negative breast cancer., PMID:38639528
Molecular Regulation of Porcine Skeletal Muscle Development: Insights from Research on CDC23 Expression and Function., PMID:38612477
CDK9-55 guides the anaphase-promoting complex/cyclosome (APC/C) in choosing the DNA repair pathway choice., PMID:38433256
Homozygous variants in CDC23 cause female infertility characterized by oocyte maturation defects., PMID:37768355
CDC23 knockdown suppresses the proliferation, migration and invasion of liver cancer via the EMT process., PMID:37274472
Identification of transcription factors and construction of a novel miRNA regulatory network in primary osteoarthritis by integrated analysis., PMID:34856957
Identification of miRNA-mRNA network and immune-related gene signatures in IgA nephropathy by integrated bioinformatics analysis., PMID:34823491
Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells., PMID:33863878
Comprehensive Analysis of Differently Expressed and Methylated Genes in Preeclampsia., PMID:33204297
Cell division cycle 23 is required for mouse oocyte meiotic maturation., PMID:32449168
Wasabi Compound 6-(Methylsulfinyl) Hexyl Isothiocyanate Induces Cell Death with Coexisting Mitotic Arrest and Autophagy in Human Chronic Myelogenous Leukemia K562 Cells., PMID:31771225
RNA insertion in DNA as the imprint moiety: the fission yeast paradigm., PMID:31076844
Differential gene expression induced by Verteporfin in endometrial cancer cells., PMID:30846786
Role of Cdc23/Mcm10 in generating the ribonucleotide imprint at the mat1 locus in fission yeast., PMID:30759238
Low-dose staurosporine selectively reverses BCR-ABL-independent IM resistance through PKC-α-mediated G2/M phase arrest in chronic myeloid leukaemia., PMID:30618318
Transcriptome profiling of human oocytes experiencing recurrent total fertilization failure., PMID:30559372
Silencing of lncRNA LINC00514 inhibits the malignant behaviors of papillary thyroid cancer through miR-204-3p/CDC23 axis., PMID:30553447
Hydrogen peroxide prolongs mitotic arrest in a dose dependent manner and independently of the spindle assembly checkpoint activity in Saccharomyces cerevisiae., PMID:29262707
APC/CCDC20 and APC/C play pivotal roles in the process of embryonic development in Artemia sinica., PMID:27991546
Data collection with a tailored X-ray beam size at 2.69 Å wavelength (4.6 keV): sulfur SAD phasing of Cdc23(Nterm)., PMID:26960127
Atomic structure of the APC/C and its mechanism of protein ubiquitination., PMID:26083744
Expression of miR-34c induces G2/M cell cycle arrest in breast cancer cells., PMID:25064703
microRNA-504 inhibits cancer cell proliferation via targeting CDK6 in hypopharyngeal squamous cell carcinoma., PMID:24647829
The four canonical tpr subunits of human APC/C form related homo-dimeric structures and stack in parallel to form a TPR suprahelix., PMID:23583778
Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex., PMID:23288039
OLSVis: an animated, interactive visual browser for bio-ontologies., PMID:22646023
CDC23 regulates cancer cell phenotype and is overexpressed in papillary thyroid cancer., PMID:21990323
Mcm10 interacts with Rad4/Cut5(TopBP1) and its association with origins of DNA replication is dependent on Rad4/Cut5(TopBP1)., PMID:21945095
Structural basis for the subunit assembly of the anaphase-promoting complex., PMID:21307936
Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture., PMID:20206185
Analysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism., PMID:19362536
Genetic profile of Egyptian hepatocellular-carcinoma associated with hepatitis C virus Genotype 4 by 15 K cDNA microarray: preliminary study., PMID:18959789
Serial analysis of the vascular endothelial transcriptome under static and shear stress conditions., PMID:18505769
Mcml0 and DNA replication in fission yeast., PMID:18368917
Structurally related TPR subunits contribute differently to the function of the anaphase-promoting complex in Drosophila melanogaster., PMID:17878237
The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast., PMID:17112379
Components of the spindle assembly checkpoint regulate the anaphase-promoting complex during meiosis in Caenorhabditis elegans., PMID:17057243
Fission yeast Mcm10p contains primase activity., PMID:16720577
An architectural map of the anaphase-promoting complex., PMID:16481473
Bioinformatic analyses implicate the collaborating meiotic crossover/chiasma proteins Zip2, Zip3, and Spo22/Zip4 in ubiquitin labeling., PMID:16314568
Depletion of anaphase-promoting complex or cyclosome (APC/C) subunit homolog APC1 or CDC27 of Trypanosoma brucei arrests the procyclic form in metaphase but the bloodstream form in anaphase., PMID:15994309
Nuclear distribution and chromatin association of DNA polymerase alpha-primase is affected by TEV protease cleavage of Cdc23 (Mcm10) in fission yeast., PMID:15941470
Changes in the localization of the Saccharomyces cerevisiae anaphase-promoting complex upon microtubule depolymerization and spindle checkpoint activation., PMID:15280225
For research use only. Not for human or drug use.
