Catalog No.
YHK00201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln100-Ser351
Predicted molecular weight
30.56 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96EV8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Dysbindin-1, Dysbindin, BLOC1S8, BLOC-1 subunit 8, HPS7 protein, Dystrobrevin-binding protein 1, Hermansky-Pudlak syndrome 7 protein, DTNBP1, Biogenesis of lysosome-related organelles complex 1 subunit 8
Exact box-counting and temporal sampling algorithms for fractal dimension estimation with applications to animal behavior analysis., PMID:40230598
Association of DBNDD1 with prognostic and immune biomarkers in invasive breast cancer., PMID:39979699
Dysbindin-1 Mutation Alters Prefrontal Cortex Extracellular Glutamate and Dopamine In Vivo., PMID:39684450
Loss of dysbindin-1 in excitatory neurons in mice impacts NMDAR-dependent behaviors, neuronal morphology and synaptic transmission in the ventral hippocampus., PMID:38956130
Sex dimorphism controls dysbindin-related cognitive dysfunctions in mice and humans with the contribution of COMT., PMID:38532008
Expression of Concern: Synaptic Dysbindin-1 Reductions in Schizophrenia Occur in an Isoform-Specific Manner Indicating Their Subsynaptic Location., PMID:38507352
Pre-Pulse Inhibition of an escape response in adult fruit fly, Drosophila melanogaster., PMID:38343805
Vaccinia-related kinase 2 variants differentially affect breast cancer growth by regulating kinase activity., PMID:38186576
Unraveling Hermansky-Pudlak syndrome type 7: a case report and comprehensive literature review on the identification of DTNBP1 variants., PMID:38097925
Prefrontal and Hippocampal Parvalbumin Interneurons in Animal Models for Schizophrenia: A Systematic Review and Meta-analysis., PMID:37584417
Dysbindin Domain-Containing 1 in Prostate Cancer: New Insights into Bioinformatic Validation of Molecular and Immunological Features., PMID:37569304
SYMPTOM SEVERITY IN SCHIZOPHRENIA PATIENTS WITH NPAS3, DYSBINDIN-1 AND/OR TRIOBP PROTEIN PATHOLOGY IN THEIR BLOOD SERUM: A PANSS-BASED FOLLOW UP STUDY., PMID:37480305
The Role of Dopamine D3 Receptors, Dysbindin, and Their Functional Interaction in the Expression of Key Genes for Neuroplasticity and Neuroinflammation in the Mouse Brain., PMID:37240042
Dopaminergic signalling and behavioural alterations by Comt-Dtnbp1 genetic interaction and their clinical relevance., PMID:37218669
Hermansky-Pudlak syndrome with early onset inflammatory bowel disease due to loss of dysbindin expression., PMID:37172778
Correction to: Dysbindin-1 is a synaptic and microtubular protein that binds brain snapin., PMID:37070456
Understanding translational research in schizophrenia: A novel insight into animal models., PMID:36692676
Methylation pattern and mRNA expression of synapse-relevant genes in the MAM model of schizophrenia in the time-course of adolescence., PMID:36481661
Genetic polymorphism and neuroanatomical changes in schizophrenia., PMID:36374137
The diagnostic yield, candidate genes, and pitfalls for a genetic study of intellectual disability in 118 middle eastern families., PMID:36344539
Exposure to Circadian Disruption During Adolescence Interacts With a Genetic Risk Factor to Modify Schizophrenia-relevant Behaviors in a Sex-dependent Manner., PMID:36168739
α-Dystrobrevin knockout mice have increased motivation for appetitive reward and altered brain cannabinoid receptor 1 expression., PMID:36045406
Dysbindin-1A modulation of astrocytic dopamine and basal ganglia dependent behaviors relevant to schizophrenia., PMID:35821415
Dysbindin-1, BDNF, and GABAergic Transmission in Schizophrenia., PMID:35815020
The E3 ligase Thin controls homeostatic plasticity through neurotransmitter release repression., PMID:35796533
Neurobiology of Schizophrenia: A Comprehensive Review., PMID:35541299
NGS-based targeted sequencing identified two novel variants in Southwestern Chinese families with oculocutaneous albinism., PMID:35488210
Backbone and side chain resonance assignment of the intrinsically disordered human DBNDD1 protein., PMID:35474152
Hermansky-Pudlak Syndrome: Identification of Novel Variants in the Genes HPS3, HPS5, and DTNBP1 (HPS-7)., PMID:35126127
Protein Kinase B/Akt1 Phosphorylates Dysbindin-1A at Serine 10 to Regulate Neuronal Development., PMID:35124166
Mechanical ventilation induces lung and brain injury through ATP production, P2Y1 receptor activation and dopamine release., PMID:35034579
Objective to identify and verify the regulatory mechanism of DTNBP1 as a prognostic marker for hepatocellular carcinoma., PMID:34997064
Long-lasting rescue of schizophrenia-relevant cognitive impairments via risperidone-loaded microPlates., PMID:34973133
Protein Aggregation of NPAS3, Implicated in Mental Illness, Is Not Limited to the V304I Mutation., PMID:34834422
Association of dysbindin expression with individualized postoperative prognosis and chemotherapy benefit among patients with gastric adenocarcinoma., PMID:34659563
Automatic Intra-/Extra-Dimensional Attentional Set-Shifting Task in Adolescent Mice., PMID:34349628
Myospryn deficiency leads to impaired cardiac structure and function and schizophrenia-associated symptoms., PMID:34037836
Cortical copper transporter expression in schizophrenia: interactions of risk gene dysbindin-1., PMID:33890175
Dysbindin-1 regulates mitochondrial fission and gamma oscillations., PMID:33589740
Risk Genes in Schizophrenia and Their Importance in Choosing the Appropriate Antipsychotic Treatment., PMID:33588721
A zinc transporter, transmembrane protein 163, is critical for the biogenesis of platelet dense granules., PMID:33513603
Schizophrenia-associated dysbindin modulates axonal mitochondrial movement in cooperation with p150glued., PMID:33461576
Abnormalities in the copper transporter CTR1 in postmortem hippocampus in schizophrenia: A subregion and laminar analysis., PMID:33434736
Markers of copper transport in the cingulum bundle in schizophrenia., PMID:33434726
Mice with dopaminergic neuron-specific deletion of DTNBP-1 gene show blunted nucleus accumbens dopamine release and associated behaviors., PMID:33340529
GPRASP/ARMCX Protein Family: Potential Involvement in Health and Diseases Revealed by their Novel Interacting Partners., PMID:33267763
Loss of Dysbindin Implicates Synaptic Vesicle Replenishment Dysregulation as a Potential Pathogenic Mechanism in Schizophrenia., PMID:33186610
Dysbindin deficiency Alters Cardiac BLOC-1 Complex and Myozap Levels in Mice., PMID:33142804
Interactions between knockout of schizophrenia risk factor Dysbindin-1 and copper metabolism in mice., PMID:32795490
For research use only. Not for human or drug use.
