Catalog No.
YHK00101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met8-Gln199
Predicted molecular weight
24.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6V1X1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DPP VIII, DPRP-1, Dipeptidyl peptidase 8, Dipeptidyl peptidase VIII, DPRP1, DP8, DPP8, Dipeptidyl peptidase IV-related protein 1, Prolyl dipeptidase DPP8
Dipeptidyl Peptidase 9 in Human Leukocytes: Novel Inhibitors Induce Caspase-1- and Gasdermin-Dependent Cell Death., PMID:40498275
A fluorescent sensor for real-time monitoring of DPP8/9 reveals crucial roles in immunity and cancer., PMID:40355159
DPP8/9 processing of human AK2 unmasks an IAP binding motif., PMID:40312560
Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors., PMID:40180908
Changes in the Proteomic Profile After Audiogenic Kindling in the Inferior Colliculus of the GASH/Sal Model of Epilepsy., PMID:40076950
A phase 2 basket study of talabostat, a small-molecule inhibitor of dipeptidyl peptidases, administered in combination with pembrolizumab in patients with advanced solid cancers., PMID:39853679
An Interdisciplinary Approach Provides Insights into the Pronounced Selectivity of Compound 42 for DPP9., PMID:39552560
Deep quantification of substrate turnover defines protease subsite cooperativity., PMID:39468329
Cosolvent Molecular Dynamics Applied to DPP4, DPP8 and DPP9: Reproduction of Important Binding Features and Use in Inhibitor Design., PMID:39332821
Discovery of the selective and nanomolar inhibitor of DPP-4 more potent than sitagliptin by structure-guided rational design., PMID:39265251
Vaccinia virus F1L blocks the ribotoxic stress response to subvert ZAKα-dependent NLRP1 inflammasome activation., PMID:39086059
CARD8: A Novel Inflammasome Sensor with Well-Known Anti-Inflammatory and Anti-Apoptotic Activity., PMID:38920661
Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability., PMID:38874443
A combination of virtual screening, molecular dynamics simulation, MM/PBSA, ADMET, and DFT calculations to identify a potential DPP4 inhibitor., PMID:38565703
N-terminal processing by dipeptidyl peptidase 9: Cut and Go!, PMID:38461970
DPP8/9 inhibition attenuates the TGF-β1-induced excessive deposition of extracellular matrix (ECM) in human mesangial cells via Smad and Akt signaling pathways., PMID:38458339
Integrative bioinformatics analysis of biomarkers and pathways for exploring the mechanisms and molecular targets associated with pyroptosis in type 2 diabetes mellitus., PMID:38034011
DPP8/9 are not Required to Cleave Most Proline-Containing Peptides., PMID:37982048
CASP1 is a target for combination therapy in pancreatic cancer., PMID:37949157
DPP9 Comes of Age: Highly Selective Inhibitors Promise New Therapeutic Opportunities., PMID:37721863
Highly Selective Inhibitors of Dipeptidyl Peptidase 9 (DPP9) Derived from the Clinically Used DPP4-Inhibitor Vildagliptin., PMID:37721854
Non-Specific Inhibition of Dipeptidyl Peptidases 8/9 by Dipeptidyl Peptidase 4 Inhibitors Negatively Affects Mesenchymal Stem Cell Differentiation., PMID:37510747
A review of standardized high-throughput cardiovascular phenotyping with a link to metabolism in mice., PMID:37326672
The amino-dipeptidyl peptidases DPP8 and DPP9: Purification and enzymatic assays., PMID:37230592
CARD8 Inflammasome Activation by HIV-1 Protease., PMID:37074642
DPP8 Selective Inhibitor Tominostat as a Novel and Broad-Spectrum Anticancer Agent against Hematological Malignancies., PMID:37048172
Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation., PMID:36649711
Viral proteases activate the CARD8 inflammasome in the human cardiovascular system., PMID:36129453
Chemoproteomics-Enabled Identification of 4-Oxo-β-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9., PMID:36089535
Vildagliptin-Derived Dipeptidyl Peptidase 9 (DPP9) Inhibitors: Identification of a DPP8/9-Specific Lead., PMID:35760756
Synthesis of β-Amino Carbonyl 6-(Aminomethyl)- and 6-(Hydroxymethyl)pyrazolopyrimidines for DPP-4 Inhibition Study., PMID:35702778
KSHV-encoded ORF45 activates human NLRP1 inflammasome., PMID:35618833
A ubiquitin-independent proteasome pathway controls activation of the CARD8 inflammasome., PMID:35580636
XaaP-ing DPP8/9 for CARD8 activation., PMID:35165444
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome., PMID:35165443
Circulating Dipeptidyl Peptidase Activity Is a Potential Biomarker for Inflammatory Bowel Disease., PMID:35060938
DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma., PMID:34737215
Dipeptidyl peptidase-8 induces sorafenib resistance via binding with c-Rel to mediate NF-κB signaling in hepatocellular carcinoma., PMID:34719075
Aerosol-based ligand soaking of reservoir-free protein crystals., PMID:34188616
Design, synthesis and biological evaluation of glycolamide, glycinamide, and β-amino carbonyl 1,2,4-triazole derivatives as DPP-4 inhibitors., PMID:34147879
Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment., PMID:34019797
Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells., PMID:33932609
DPP9: Comprehensive In Silico Analyses of Loss of Function Gene Variants and Associated Gene Expression Signatures in Human Hepatocellular Carcinoma., PMID:33915844
Protease-mediated processing of Argonaute proteins controls small RNA association., PMID:33852894
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation., PMID:33731932
Structural and biochemical mechanisms of NLRP1 inhibition by DPP9., PMID:33731929
Activation of the CARD8 Inflammasome Requires a Disordered Region., PMID:33053349
Inflammasome Assays In Vitro and in Mouse Models., PMID:33017103
Decrease of the pro-inflammatory M1-like response by inhibition of dipeptidyl peptidases 8/9 in THP-1 macrophages - quantitative proteomics of the proteome and secretome., PMID:32998073
Structural optimization of pyrazolo[1,5-a]pyrimidine derivatives as potent and highly selective DPP-4 inhibitors., PMID:32987315
For research use only. Not for human or drug use.
