Catalog No.
YHJ99401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly295-Asn469
Predicted molecular weight
22.03 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99518
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FMO 1B1, FMO 2, Dimethylaniline monooxygenase [N-oxide-forming] 2, Pulmonary flavin-containing monooxygenase 2, Dimethylaniline oxidase 2, FMO2
FMO2 Prevents Pathological Cardiac Hypertrophy by Maintaining the ER-Mitochondria Association Through Interaction With IP3R2-Grp75-VDAC1., PMID:40489543
FMO3 exacerbates hepatic endoplasmic reticulum stress in drug-induced liver injury by inhibiting CREB3/P4HB axis and activating TMAO-mediated PERK pathway., PMID:40345485
FMO2+ cancer-associated fibroblasts sensitize anti-PD-1 therapy in patients with hepatocellular carcinoma., PMID:40316306
CELF1 Promotes Post-myocardial Infarction Cardiac Remodeling Via Suppression of FMO2., PMID:40021568
fmo-4 promotes longevity and stress resistance via ER to mitochondria calcium regulation in C. elegans., PMID:39951337
Sulfur Dioxide Alleviates Aortic Dissection Through Inhibiting Vascular Smooth Muscle Cell Phenotype Switch, Migration, and Proliferation via miR-184-3p/Cyp26b1 Axis., PMID:39834177
Transgenic expression of SeCYP9A186 and PxFMO2 confers resistance to emamectin benzoate in Plutella xylostella., PMID:39651894
Transcriptional analysis of C. elegans fmos at different life stages and their roles in ageing., PMID:39636438
Fecal microbiota transplantation validates the importance of gut microbiota in an ApoE-/- mouse model of chronic apical periodontitis-induced atherosclerosis., PMID:39614243
Flavin-Dependent Monooxgenase Confers Resistance to Chlorantraniliprole and Spinetoram in the Rice Stem Borer Chilo suppressalis Walker (Lepidoptera: Crambidae)., PMID:39561259
Exercise training attenuates cardiac dysfunction induced by excessive sympathetic activation through an AMPK-KLF4-FMO2 axis., PMID:39491669
Flavin-containing monooxygenase 2 confers cardioprotection in ischemia models through its disulfide bond catalytic activity., PMID:39480513
Production of bio-indigo from engineered Pseudomonas putida KT2440 harboring tryptophanase and flavin-containing monooxygenase., PMID:39447513
Fibroblast-specific TGF-β signaling mediates cardiac dysfunction, fibrosis, and hypertrophy in obese diabetic mice., PMID:39373248
Structural and Functional Characterization of a Novel Class A Flavin Monooxygenase from Bacillus niacini., PMID:39265075
Semi-rational design based on the interaction between SmFMO and FAD isoalloxazine ring to enhance the enzyme activity., PMID:39197199
Deficiency of flavin-containing monooxygenase 3 protects kidney function after ischemia-reperfusion in mice., PMID:39191965
TMAO induces pyroptosis of vascular endothelial cells and atherosclerosis in ApoE-/- mice via MBOAT2-mediated endoplasmic reticulum stress., PMID:39179098
Interactions between the gut microbiome, associated metabolites and the manifestation and progression of heart failure with preserved ejection fraction in ZSF1 rats., PMID:39143579
Asymmetric Sulfoxidations Catalyzed by Bacterial Flavin-Containing Monooxygenases., PMID:39124879
Fmo induction as a tool to screen for pro-longevity drugs., PMID:38787463
Identification of YUC genes associated with leaf wrinkling trait in Tacai variety of Chinese cabbage., PMID:38784401
Mechanism of Nitrone Formation by a Flavin-Dependent Monooxygenase., PMID:38779817
Quinuclidine N-Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs., PMID:38769015
Flavin-containing monooxygenase (FMO): Beyond xenobiotics., PMID:38713170
Hif-1α expression targets the TMA/Fmo3/TMAO axis to participate in gallbladder cholesterol stone formation in individuals living in plateau regions., PMID:38657913
Impact of CYP2C19, CYP2C9, CYP3A4, and FMO3 Genetic Polymorphisms and Sex on the Pharmacokinetics of Voriconazole after Single and Multiple Doses in Healthy Chinese Subjects., PMID:38654529
Flavin-containing monooxygenases FMOGS-OXs integrate flowering transition and salt tolerance in Arabidopsis thaliana., PMID:38606719
Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes., PMID:38520539
A variety of cytochrome P450 enzymes and flavin-containing monooxygenases in dogs and pigs commonly used as preclinical animal models., PMID:38490520
Genetic Biomarkers of Sorafenib Response in Patients with Hepatocellular Carcinoma., PMID:38396873
Deciphering the diurnal rhythm regulating mechanism of flavin-containing monooxygenase 3 in mouse liver., PMID:38320728
Rare but impaired flavin-containing monooxygenase 3 (FMO3) variants reported in a recently updated Japanese mega-databank of genome resources., PMID:38280279
Genome-Wide Association Study of Milk Composition in Karachai Goats., PMID:38275787
Molecular and functional characterization of flavin-containing monooxygenases (FMO1-6) in tree shrews., PMID:38215804
Tryptophan-Based Hyperproduction of Bioindigo by Combinatorial Overexpression of Two Different Tryptophan Transporters., PMID:38213292
A computational insight on the aromatic amino acids conjugation with [Cp*Rh(H2O)3]2+ by using the meta-dynamics/FMO3 approach., PMID:38082186
Discovery and identification of the prognostic significance and potential mechanism of FMO2 in breast cancer., PMID:37963835
FMO2 ameliorates nonalcoholic fatty liver disease by suppressing ER-to-Golgi transport of SREBP1., PMID:37874228
Circ_MACF1 targets miR-421 to upregulate FMO2 to suppress paclitaxel resistance and malignant cellular behaviors in lung adenocarcinoma., PMID:37814902
Flavin containing monooxygenase 2 regulates renal tubular cell fibrosis and paracrine secretion via SMURF2 in AKI‑CKD transformation., PMID:37800598
FMO1 Promotes Nonalcoholic Fatty Liver Disease Progression by Regulating PPARα Activation and Inducing Ferroptosis., PMID:37553313
Metabolomic and transcriptomic analyses of Fmo5-/- mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism., PMID:37267233
Meta-analysis of RNA-Seq datasets highlights novel genes/pathways involved in fat deposition in fat-tail of sheep., PMID:37252399
Increased Thermostability of an Engineered Flavin-Containing Monooxygenase to Remediate Trimethylamine in Fish Protein Hydrolysates., PMID:37222584
Systematic Review of Roles of Arecoline and Arecoline N-Oxide in Oral Cancer and Strategies to Block Carcinogenesis., PMID:37190117
Estimation of FMO3 Ontogeny by Mechanistic Population Pharmacokinetic Modelling of Risdiplam and Its Impact on Drug-Drug Interactions in Children., PMID:37148485
Diabetes Induces Cardiac Fibroblast Activation, Promoting a Matrix-Preserving Nonmyofibroblast Phenotype, Without Stimulating Pericyte to Fibroblast Conversion., PMID:36892073
Bioelectrochemical platform with human monooxygenases: FMO1 and CYP3A4 tandem reactions with phorate., PMID:36446195
Further survey of genetic variants of flavin-containing monooxygenase 3 (FMO3) in Japanese subjects found in an updated database of genome resources and identified by phenotyping for trimethylaminuria., PMID:35853340
For research use only. Not for human or drug use.
