Catalog No.
DHJ82501
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG2-lambda
Clonality
Monoclonal
Target
FzE1, Frizzled-1, hFz1, Fz-1, FZD1
Concentration
1.63 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9UP38
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
OMP-18R5, CAS: 1345009-45-1
Clone ID
Vantictumab
Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review), PMID: 29786110
Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review), PMID: 29048660
Molecular genetics and targeted therapy of WNT-related human diseases (Review), PMID: 28731148
A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic cancer, PMID: 31338636
Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer, PMID: 32803633
Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations, PMID: 30622113
WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death, PMID: 28691093
Adipocytes sustain pancreatic cancer progression through a non-canonical WNT paracrine network inducing ROR2 nuclear shuttling, PMID: 29151594
Targeted activation of ferroptosis in colorectal cancer via LGR4 targeting overcomes acquired drug resistance. [DHJ82501]
For research use only. Not for human or drug use.
