Catalog No.
YHJ91201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser28-Cys314
Predicted molecular weight
34.50 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y6E7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial, SIR2-like protein 4, SIR2L4, NAD-dependent protein deacetylase sirtuin-4, NAD-dependent ADP-ribosyltransferase sirtuin-4, SIRT4, Regulatory protein SIR2 homolog 4
Endarachne binghamiae Ameliorates Hepatic Steatosis, Obesity, and Blood Glucose via Modulation of Metabolic Pathways and Oxidative Stress., PMID:40507912
SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice., PMID:40463174
Genome-Wide Study of Diabetes Mellitus (Type 2)-Associated Genes in Homo sapiens (Human)., PMID:40462586
The age-dependent impacts of treadmill exercise on cognitive impairments by reducing inflammation and oxidative stress in the hippocampus of morphine-exposed rats: the role of SIRTs 3 &4 and BDNF., PMID:40418392
SIRT4 Controls Acetyl-CoA Synthesis to Promote Stemness and Invasiveness of Hepatocellular Carcinoma through Deacetylating MCCC2., PMID:40384857
SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling., PMID:40298941
l-Carnitine and Acetyl-l-Carnitine Induce Metabolism Alteration and Mitophagy-Related Cell Death in Colorectal Cancer Cells., PMID:40290068
Sirt2 deficiency aggravates intramuscular adipose tissue infiltration and impairs myogenesis with aging in male mice., PMID:40257511
SETDB1 recruits CBX3 to regulate the SIRT4/PTEN axis, inhibiting autophagy and promoting ischemia-reperfusion-induced kidney injury., PMID:40197868
The Antiaging and Antioxidative Effects of a Combination of Resveratrol and High-Intensity Interval Training on the Frontal Lobe in Aged Rats: The Role of SIRTS 4, SIRTS 5, SOD1, and SOD2., PMID:39959582
Modulation of sirtuin expression by a high-sugar diet and regular swimming trained precedes the loss of kidney function., PMID:39907422
Diurnal variation in skeletal muscle mitochondrial function dictates time-of-day-dependent exercise capacity., PMID:39902884
SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression., PMID:39873651
The curious case of mitochondrial sirtuin in rewiring breast cancer metabolism: Mr Hyde or Dr Jekyll?, PMID:39864670
Molecular Sentinels: Unveiling the Role of Sirtuins in Prostate Cancer Progression., PMID:39796040
Inhibition of SIRT4 promotes bladder cancer progression and immune escape via attenuating CD8+ T cells function., PMID:39756164
Targeting sirtuins in neurological disorders: A comprehensive review., PMID:39736297
Genetic variants in mitochondrial sirtuins associated with brain tumor risk: a case-control study., PMID:39560005
Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2., PMID:39495216
Targeting sirtuins for cancer therapy: epigenetics modifications and beyond., PMID:39479446
Sirt4 Overexpression Modulates the JAK2/STAT3 and PI3K/AKT/mTOR Axes to Alleviate Sepsis-Induced Acute Lung Injury., PMID:39400781
Lock out SIRT4., PMID:39269433
Sodium butyrate blocks the growth of colorectal cancer by inhibiting the aerobic glycolysis mediated by SIRT4/HIF-1α., PMID:39241941
A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue., PMID:39226092
Roles of Sirtuins in Hearing Protection., PMID:39204103
NMN partially rescues cuproptosis by upregulating sirt2 to increase intracellular NADPH., PMID:39169144
Decreased sirtuin 4 levels promote cellular proliferation and invasion in papillary thyroid carcinoma., PMID:39121020
Regulatory factor X7 Represses Ox-LDL-Induced Proliferation and Migration of VSMCs via SIRT4-Mediated Inactivation of JAK2/STAT3 Pathway., PMID:39085113
SIRT4 is associated with microvascular infiltration, immune cell infiltration, and epithelial mesenchymal transition in hepatocellular carcinoma., PMID:39082202
SIRTifying intestinal nucleotide metabolism., PMID:39034176
Characterizing mitochondrial features in osteoarthritis through integrative multi-omics and machine learning analysis., PMID:39026663
SIRT4 Protects Müller Glial Cells Against Apoptosis by Mediating Mitochondrial Dynamics and Oxidative Stress., PMID:39023793
Diethyl phthalate and dibutyl phthalate disrupt sirtuins expression in the HepG2 cells., PMID:39006882
The Role of Mitochondrial Sirtuins (SIRT3, SIRT4 and SIRT5) in Renal Cell Metabolism: Implication for Kidney Diseases., PMID:39000044
SIRT4 Has an Anti-Cancer Role in Cervical Cancer by Inhibiting Glutamine Metabolism via the MEK/ERK/C-Myc Axis., PMID:38925807
Mitochondrial Sirtuins in Cancer: A Revisited Review from Molecular Mechanisms to Therapeutic Strategies., PMID:38773972
SIRT4 promotes neuronal apoptosis in models of Alzheimer's disease via the STAT2-SIRT4-mTOR pathway., PMID:38586875
Gene expression patterns of Sirtuin family members (SIRT1 TO SIRT7): Insights into pathogenesis and prognostic of Myelodysplastic neoplasm., PMID:38575099
SIRT3 and SIRT4 double-genes remodeled the mitochondrial network to induce hepatocellular carcinoma cell line differentiation and suppress malignant phenotypes., PMID:38548246
Silencing KLF6 Alleviates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction in Bronchial Epithelial Cells by SIRT4 Upregulation., PMID:38544929
SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis., PMID:38507411
SIRT4 as a novel interactor and candidate suppressor of C-RAF kinase in MAPK signaling., PMID:38499327
Sirtuins as Players in the Signal Transduction of Citrus Flavonoids., PMID:38396635
Sirtuin 4 (Sirt4) downregulation contributes to chondrocyte senescence and osteoarthritis via mediating mitochondrial dysfunction., PMID:38385071
Mitochondrial sirtuins: Energy dynamics and cancer metabolism., PMID:38331199
Glutamine sustains energy metabolism and alleviates liver injury in burn sepsis by promoting the assembly of mitochondrial HSP60-HSP10 complex via SIRT4 dependent protein deacetylation., PMID:38329114
Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity., PMID:38253001
Biodegradable Zn-5Dy Alloy with Enhanced Osteo/Angio-Genic Activity and Osteointegration Effect via Regulation of SIRT4-Dependent Mitochondrial Function., PMID:38243646
NSUN2-Mediated m5C Methylation Impairs Endometrial Receptivity., PMID:38237738
Shrimp SIRT4 promotes white spot syndrome virus replication., PMID:38142022
For research use only. Not for human or drug use.
