Research Grade Brontictuzumab (DHE48301)

Catalog No.

DHE48301

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG2-lambda

Clonality

Monoclonal

Target

hN1, TAN1, NEXT, NICD, Notch 1, Neurogenic locus notch homolog protein 1, Translocation-associated notch protein TAN-1, NOTCH1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P46531

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

OMP-52M51, CAS: 1447814-75-6

Clone ID

Brontictuzumab

A phase I dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors, PMID: 29726923

A computational guided, functional validation of a novel therapeutic antibody proposes Notch signaling as a clinical relevant and druggable target in glioma, PMID: 33004830

Alterations of Notch pathway in patients with adenoid cystic carcinoma of the trachea and its impact on survival, PMID: 29858025

Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors, PMID: 27870570

Document Download

Research Grade Brontictuzumab.pdf