Catalog No.
DHB94405
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Mouse
Isotype
F(ab')2-G3-kappa
Clonality
Monoclonal
Target
TNF, Tumor necrosis factor ligand superfamily member 2, N-terminal fragment, ICD2, NTF, TNF-a, TNF-alpha, Tumor necrosis factor, TNFSF2, TNFA, Cachectin, ICD1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P01375
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
MAK-195F, CAS: 156227-98-4
Clone ID
Afelimomab
[Anti-inflammatory therapy in sepsis], PMID: 12883811
[Anti-inflammatory treatment in sepsis], PMID: 12430058
A multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-alpha antibody afelimomab in patients with sepsis syndrome, PMID: 11534565
Afelimomab led to a modest mortality benefit in patients with severe sepsis and elevated interleukin-6 levels, PMID: 16277704
Afelimomab, PMID: 10829362
Afelimomab-another therapeutic option in sepsis therapy?, PMID: 15640652
Anti-tumor necrosis factor therapy in sepsis: update on clinical trials and lessons learned, PMID: 11445746
Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels, PMID: 15640628
Emerging drugs for the treatment of sepsis, PMID: 22780561
Endothelin in septic patients: effects on cardiovascular and renal function and its relationship to proinflammatory cytokines, PMID: 10890632
MONARCS: statistical or clinical meaning?, PMID: 16148507
Randomized, placebo-controlled trial of the anti-tumor necrosis factor antibody fragment afelimomab in hyperinflammatory response during severe sepsis: The RAMSES Study, PMID: 11373466
Whose loss is it? Human electrophysiological correlates of non-self reward processing, PMID: 19191194
For research use only. Not for human or drug use.
