Catalog No.
YHJ71501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu82-Asp292
Predicted molecular weight
26.03 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9P1W9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pim-2h, Serine/threonine-protein kinase pim-2, PIM2
Deterioration of nutritional status at discharge in critically ill children with appropriate BMI and its association with clinical outcomes: a prospective observational study., PMID:40442695
PIM kinase control of CD8 T cell protein synthesis and cell trafficking., PMID:40359130
BCOR and ZC3H12A suppress a core stemness program in exhausted CD8+ T cells., PMID:40327039
Relating the molecular phenotype of ulcerative colitis to the clinical course., PMID:40064933
Targeting of PIM Kinases Shows Single Agent Efficacy and Synergizes With BCL2 Inhibitors in Diffuse Large B Cell Lymphoma of the ABC Subtype., PMID:40040616
Targeting macrophage polarization by inhibiting Pim2 alleviates inflammatory arthritis via metabolic reprogramming., PMID:40000906
PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression., PMID:39747141
A putative mycobacterial GDP-mannose dependent α-mannosyltransferase Rv0225 acts as PimC: an in-silico study., PMID:39660564
Integrative multi-omics analysis of Crohn's disease and metabolic syndrome: Unveiling the underlying molecular mechanisms of comorbidity., PMID:39541897
SPOP-mediated RIPK3 destabilization desensitizes LPS/sMAC/zVAD-induced necroptotic cell death., PMID:39540935
PIM1 kinase and its diverse substrate in solid tumors., PMID:39487435
Heterocycle-functional steroidal derivatives: Design, synthesis, bioevaluation and SARs of steroidal pyrazolo[1,5-a]pyrimidines as potential ALK inhibitors., PMID:39348750
Regulation of cagA-Helicobacter on gastric PIM2 expression in gastric cancer., PMID:39331090
PIM Kinase Inhibitors as Novel Promising Therapeutic Scaffolds in Cancer Therapy., PMID:39297470
Identifying hub genes for chemo-radiotherapy sensitivity in cervical cancer: a bi-dataset in silico analysis., PMID:39264467
The role of Pim-1 kinases in inflammatory signaling pathways., PMID:39079978
Phosphorylation of USP27X by PIM2 promotes glycolysis and breast cancer progression via deubiquitylation of MYC., PMID:38969771
Identification of potential PIM-2 inhibitors via ligand-based generative models, molecular docking and molecular dynamics simulations., PMID:38954072
Neuronal expression of herpes simplex virus-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation., PMID:38869285
PIM kinase inhibitors: an updated patent review (2016-present)., PMID:38842051
Cardiac differentiation is modulated by anti-apoptotic signals in murine embryonic stem cells., PMID:38817332
Nutritional status and clinical outcomes of brain tumor surgery in pediatric intensive care unit: A prospective cohort study., PMID:38777448
Stage-related increase in PIM2 expression in mycosis fungoides., PMID:38757234
A review on structure-function mechanism and signaling pathway of serine/threonine protein PIM kinases as a therapeutic target., PMID:38704069
Regnase-1 D141N mutation induces CD4+ T cell-mediated lung granuloma formation via upregulation of Pim2., PMID:38700370
PIM Kinase Inhibition Sensitizes Neuroblastoma to Doxorubicin., PMID:38570263
PIM Kinases as Potential Biomarkers and Therapeutic Targets in Inflammatory Arthritides., PMID:38542097
LncRNA AA465934 Improves Podocyte Injury by Promoting Tristetraprolin-Mediated HMGB1 DownRegulation in Diabetic Nephropathy., PMID:38520226
Identification and assessment of new PIM2 inhibitors for treating hematologic cancers: A combined approach of energy-based virtual screening and machine learning evaluation., PMID:38263717
Acute suppression of translation by hyperthermia enhances anti-myeloma activity of carfilzomib., PMID:38252236
Acute accumulation of PIM2 and NRF2 and recovery of β5 subunit activity mitigate multiple myeloma cell susceptibility to proteasome inhibitors., PMID:38245883
Comprehensive Insights that Targeting PIM for Cancer Therapy: Prospects and Obstacles., PMID:38164076
Targeting PIM kinases in cancer therapy: An update on pharmacological small-molecule inhibitors., PMID:38071792
Identification of immunological characterization and Anoikis-related molecular clusters in rheumatoid arthritis., PMID:38046810
PIM kinases regulate early human Th17 cell differentiation., PMID:38039135
The acetylation of STAT3 at K685 attenuates NPM-ALK-induced tumorigenesis., PMID:38000524
Pim Kinases: Important Regulators of Cardiovascular Disease., PMID:37511341
Undernutrition and 60-day mortality in critically ill children with respiratory failure: a prospective cohort study., PMID:37248480
Protective effects of cell permeable Tat-PIM2 protein on oxidative stress induced dopaminergic neuronal cell death., PMID:37223703
Final step of B-cell differentiation into plasmablasts; the right time to activate plasma cell PIM2 kinase., PMID:37207916
PIM2 Promotes the Development of Ovarian Endometriosis by Enhancing Glycolysis and Fibrosis., PMID:37059967
Lymphocyte to monocyte ratio predicts survival and is epigenetically linked to miR-222-3p and miR-26b-5p in diffuse large B cell lymphoma., PMID:36966176
Inhibition of PIM Kinases Promotes Neuroblastoma Cell Differentiation to a Neuronal Phenotype., PMID:36907773
An XBP1s-PIM-2 positive feedback loop controls IL-15-mediated survival of natural killer cells., PMID:36897958
Detection of myeloma cell-derived microvesicles: a tool to monitor multiple myeloma load., PMID:36879302
Pediatric sepsis diagnostic and prognostic biomarkers: pancreatic stone protein, copeptin, and apolipoprotein A-V., PMID:36755189
Targeting Pim kinases in hematological cancers: molecular and clinical review., PMID:36694243
Discovery of new pyridine-quinoline hybrids as competitive and non-competitive PIM-1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities., PMID:36629075
Novel antimyeloma therapeutic option with inhibition of the HDAC1-IRF4 axis and PIM kinase., PMID:36129197
Phosphorylation of PFKFB4 by PIM2 promotes anaerobic glycolysis and cell proliferation in endometriosis., PMID:36109523
For research use only. Not for human or drug use.
