Catalog No.
YHJ70601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn315-Glu537
Predicted molecular weight
28.10 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9P0J1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PDP 1, Pyruvate dehydrogenase phosphatase catalytic subunit 1, PDP1, PDPC 1, [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial, PPM2C, Protein phosphatase 2C, PDP
Emerging roles of pyruvate dehydrogenase phosphatase 1: a key player in metabolic health., PMID:40491447
Functional characterization of the second feedback loop in the circadian clock of the Antarctic krill Euphausia superba., PMID:39716211
Genome-wide identification of PAR domain protein 1 (PDP1) targets through ChIP-seq reveals the regulation of diapause-specific characteristics in Culex pipiens., PMID:38989821
PDP1 promotes KRAS mutant colorectal cancer progression by serving as a scaffold for BRAF and MEK1., PMID:38849010
Identification of shared gene signatures and pathways for diagnosing osteoporosis with sarcopenia through integrated bioinformatics analysis and machine learning., PMID:38831425
Clock-dependent chromatin accessibility rhythms regulate circadian transcription., PMID:38805552
PDP1 promotes the progression of breast cancer through STAT3 pathway., PMID:38566355
Identification and validation of a novel cuproptosis signature for stratifying different prognostic, immune, metabolic, and therapeutic landscapes in pancreatic adenocarcinoma., PMID:38497885
The emergence of circadian timekeeping in the intestine., PMID:38413599
Decreased pyruvate dehydrogenase activity in Tafazzin-deficient cells is caused by dysregulation of pyruvate dehydrogenase phosphatase 1 (PDP1)., PMID:38301889
TARANIS Interacts with VRILLE and PDP1 to Modulate the Circadian Transcriptional Feedback Mechanism in Drosophila., PMID:38296648
TARANIS interacts with VRILLE and PDP1 to modulate the circadian transcriptional feedback mechanism in Drosophila., PMID:38076905
PDP1 is a key metabolic gatekeeper and modulator of drug resistance in FLT3-ITD-positive acute myeloid leukemia., PMID:37935978
EGR1-mediated metabolic reprogramming to oxidative phosphorylation contributes to ibrutinib resistance in B-cell lymphoma., PMID:37738652
Clock-dependent chromatin accessibility rhythms regulate circadian transcription., PMID:37645872
Transcriptome profiling of A549 non-small cell lung cancer cells in response to Trichinella spiralis muscle larvae excretory/secretory products., PMID:37601754
Analysis of lactate metabolism-related genes and their association with immune infiltration in septic shock via bioinformatics method., PMID:37564869
Pyruvate dehydrogenase phosphatase 1 (PDP1) stimulates HIF activity by supporting histone acetylation under hypoxia., PMID:36453802
PDP1 Promotes Cell Malignant Behavior and Is Associated with Worse Clinical Features in Ovarian Cancer Patients: Evidence from Bioinformatics and In Vitro Level., PMID:36276992
SERBP1 affects the apoptotic level by regulating the expression and alternative splicing of cellular and metabolic process genes in HeLa cells., PMID:36213507
Constant Light, Pdp1, and Tim Exert Influence on Free-Running Period of Locomotor Rhythms in the Cricket Gryllus bimaculatus., PMID:36205367
Skeletal-Muscle-Specific Overexpression of Chrono Leads to Disruption of Glucose Metabolism and Exercise Capacity., PMID:36013411
Characterizing the relative abundance of circadian transcription factors in diapausing and nondiapausing Northern house mosquitoes., PMID:35691331
MiR-18a-3p improves cartilage matrix remodeling and inhibits inflammation in osteoarthritis by suppressing PDP1., PMID:35148687
Identification of immune-related cells and genes in the breast invasive carcinoma microenvironment., PMID:35120331
Abnormal lipid droplets accumulation induced cognitive deficits in obstructive sleep apnea syndrome mice via JNK/SREBP/ACC pathway but not through PDP1/PDC pathway., PMID:35030992
Mechanisms underlying the cooperation between loss of epithelial polarity and Notch signaling during neoplastic growth in Drosophila., PMID:35005772
Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1., PMID:34842525
Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth., PMID:34749809
PROMISed: A novel web-based tool to facilitate analysis and visualization of the molecular interaction networks from co-fractionation mass spectrometry (CF-MS) experiments., PMID:34589187
Mitochondrial dysfunction induces radioresistance in colorectal cancer by activating [Ca2+]m-PDP1-PDH-histone acetylation retrograde signaling., PMID:34489398
Characterization of Photorhabdus Virulence Cassette as a causative agent in the emerging pathogen Photorhabdus asymbiotica., PMID:34185241
TGF-β1 is a regulator of the pyruvate dehydrogenase complex in fibroblasts., PMID:33087819
Regulation of circadian rhythm and sleep by miR-375-timeless interaction in Drosophila., PMID:33078445
Functional analysis of Pdp1 and vrille in the circadian system of a cricket., PMID:33058831
Transcriptomic approach predicts a major role for transforming growth factor beta type 1 pathway in L-Dopa-induced dyskinesia in parkinsonian rats., PMID:32741046
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors., PMID:32650009
Crystal structure of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase., PMID:32627744
PDGFRα/β-PI3K-Akt pathway response to the interplay of mitochondrial dysfunction and DNA damage in Aroclor 1254-exposed porcine granulosa cells., PMID:32289613
Circadian transcription factors differentially regulate features of the adult overwintering diapause in the Northern house mosquito, Culex pipiens., PMID:32247760
Pyruvate Dehydrogenase and Tricarboxylic Acid Cycle Enzymes Are Sensitive Targets of Traumatic Brain Injury Induced Metabolic Derangement., PMID:31744143
Life at High Latitudes Does Not Require Circadian Behavioral Rhythmicity under Constant Darkness., PMID:31679928
Neuron-specific knockouts indicate the importance of network communication to Drosophila rhythmicity., PMID:31613223
Nipped-A regulates the Drosophila circadian clock via histone deubiquitination., PMID:31538360
Ortho-phenylphenol exposure impairs porcine sperm motility through AMPK/AKT signaling pathway., PMID:31454112
Salidroside Inhibits Lipopolysaccharide-ethanol-induced Activation of Proinflammatory Macrophages via Notch Signaling Pathway., PMID:31346986
Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses., PMID:31314546
Mutant huntingtin disturbs circadian clock gene expression and sleep patterns in Drosophila., PMID:31073199
Adaptations in Protein Expression and Regulated Activity of Pyruvate Dehydrogenase Multienzyme Complex in Human Systolic Heart Failure., PMID:30881593
For research use only. Not for human or drug use.
