Catalog No.
YHJ62301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met222-Pro372
Predicted molecular weight
18.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NP85
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NPHS2, Podocin
Mitigation of nicotine-induced podocyte injury through inhibition of thioredoxin interacting protein., PMID:40311224
Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin β3 in the Glomerulus., PMID:40256245
Estimation of the Age of the Kashubian-Specific Pathogenic NPHS2 Variant Responsible for Hereditary Steroid-Resistant Nephrotic Syndrome Points to Its Recent Local Origin., PMID:40225918
Podocyte specific knockout of the natriuretic peptide clearance receptor is podocyte protective in focal segmental glomerulosclerosis., PMID:40063586
Safranal Ameliorates Renal Damage, Inflammation, and Podocyte Injury in Membranous Nephropathy via SIRT/NF-κB Signalling., PMID:40035996
Modified Huangqi Chifeng decoction alleviates podocyte injury on rat with experimental membranous nephropathy., PMID:39972601
A kidney organoid-based readout to assess disease activity in primary and recurrent focal segmental glomerulosclerosis., PMID:39914654
Yiqi Yangyin Huazhuo Tongluo Formula alleviates diabetic podocyte injury by regulating miR-21a-5p/FoxO1/PINK1-mediated mitochondrial autophagy., PMID:39819709
Development of a Multiplexed LC-MS/MS Assay for the Quantitation of Podocyte Injury Biomarkers Nephrin, Podocalyxin, and Podocin in Human Urine., PMID:39651829
NPHS Mutations in Pediatric Patients with Congenital and Steroid-Resistant Nephrotic Syndrome., PMID:39596340
The glomerular circadian clock temporally regulates basement membrane dynamics and the podocyte glucocorticoid response., PMID:39515644
Evaluation of urinary podocin and nephrin as markers of podocyturia in dogs with leishmaniosis., PMID:39380100
Renin-angiotensin blockade ameliorates the progression of glomerular injury in podocyte-specific Ctcf knockout mice., PMID:39350520
Podocyte-Specific Expression of the Stress Response Protein REDD1 Is Necessary for Diabetes-Induced Podocytopenia., PMID:39320924
The Immunosuppressive Drug LF15-0195 Acts Also on Glomerular Lesions, by a Change in Cytoskeleton Distribution in Podocyte., PMID:39074452
Serum L C3-II levels in type 2 diabetic patients with impaired renal functions., PMID:38943738
MiR-33a Overexpression Exacerbates Diabetic Nephropathy Through Sirt6-dependent Notch Signaling., PMID:38904337
A novel gain-of-function mutation in transient receptor potential C6 that causes podocytes injury., PMID:38814201
c-Cbl induced podocin ubiquitination contributes to the podocytes injury in diabetic nephropathy., PMID:38752545
Ibrutinib-associated focal segmental glomerulosclerosis and the impact of podocin mutations in chronic lymphocytic leukemia., PMID:38336226
Nephrotic Syndrome in a Child With NPHS2 Mutation., PMID:38291869
In vivo characterization of a podocyte-expressed short podocin isoform., PMID:38114895
A small molecule chaperone rescues keratin-8 mediated trafficking of misfolded podocin to correct genetic Nephrotic Syndrome., PMID:37995908
Copy number variation analysis in 138 families with steroid-resistant nephrotic syndrome identifies causal homozygous deletions in PLCE1 and NPHS2 in two families., PMID:37670083
Podocin, mTOR, and CHOP dysregulation contributes to nephrotoxicity induced of lipopolysaccharide/diclofenac combination in rats: Curcumin and silymarin could afford protective effect., PMID:37536613
Deletion of protein tyrosine phosphatase SHP-1 restores SUMOylation of podocin and reverses the progression of diabetic kidney disease., PMID:37507049
Pinpointing Podocin Trafficking Defects in Kidney Organoids., PMID:36719143
Sitagliptin ameliorates diabetic nephropathy by upregulating renal nephrin and podocin expression through modulation of adipokines levels., PMID:36594370
ANGPTL4 promotes nephrotic syndrome by downregulating podocyte expression of ACTN4 and podocin., PMID:36495766
Naringin abrogates angiotensin-converting enzyme (ACE) activity and podocin signalling pathway in cobalt chloride-induced nephrotoxicity and hypertension., PMID:36480283
Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking., PMID:36167728
Phloretin ameliorates diabetic nephropathy by inhibiting nephrin and podocin reduction through a non-hypoglycemic effect., PMID:35622066
Podocyte Injury in Cases with Newly Diagnosed Multiple Myeloma., PMID:35102914
A novel NPHS2 mutation (c.865A > G) identified in a Chinese family with steroid-resistant nephrotic syndrome alters subcellular localization of nephrin., PMID:35099763
IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage., PMID:34894725
Super-Resolution Imaging of the Filtration Barrier Suggests a Role for Podocin R229Q in Genetic Predisposition to Glomerular Disease., PMID:34853150
A UFLC-MS/MS Method for the Simultaneous Analysis of Urinary Podocin and Podocalyxin in Patients with Nephrotic Syndrome., PMID:34698337
Increasing urinary podocyte mRNA excretion and progressive podocyte loss in kidney contribute to the high risk of long-term renal disease caused by preterm birth., PMID:34667204
A Study of the Risk Factors and Urinary Podocin as an Early Prognostic Indicator of Renal Injury in Diabetic Nephropathy., PMID:34472785
Huangqi Guizhi Wuwu Decoction attenuates Podocyte cytoskeletal protein damage in IgA nephropathy rats by regulating AT1R/Nephrin/c-Abl pathway., PMID:34339916
Arthrospira maxima (Spirulina) prevents endoplasmic reticulum stress in the kidney through its C-phycocyanin., PMID:34269013
Impaired NEPHRIN localization in kidney organoids derived from nephrotic patient iPS cells., PMID:33597637
Genetic screening in children with challenging nephrotic syndrome., PMID:33565430
Tongluo Digui decoction treats renal injury in diabetic rats by promoting autophagy of podocytes., PMID:33522205
Analysis of the clinical characteristics of arthritis with renal disease caused by a NPHS2 gene mutation., PMID:33428103
Urinary DPP4 correlates with renal dysfunction, and DPP4 inhibition protects against the reduction in megalin and podocin expression in experimental CKD., PMID:33346727
NPHS2 gene polymorphism aggravates renal damage caused by focal segmental glomerulosclerosis with COL4A3 mutation., PMID:33305316
SHROOM3, the gene associated with chronic kidney disease, affects the podocyte structure., PMID:33273487
Transplantation of mesenchymal stem cells preserves podocyte homeostasis through modulation of parietal epithelial cell activation in adriamycin-induced mouse kidney injury model., PMID:33124682
Evaluation of podocin in urine in horses using qualitative and quantitative methods., PMID:33057359
For research use only. Not for human or drug use.
