Research Grade Narsoplimab (DHA04501)

Catalog No.

DHA04501

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG4-lambda

Clonality

Monoclonal

Target

Mannan-binding lectin serine protease 2, Mannose-binding protein-associated serine protease 2, MASP-2, MBL-associated serine protease 2, MASP2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O00187

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

OMS721, CAS: 2108782-45-0

Clone ID

Narsoplimab

Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab, PMID: 32943233

Safety, Tolerability and Efficacy of Narsoplimab, a Novel MASP-2 Inhibitor for the Treatment of IgA Nephropathy, PMID: 33163724

Antibodies to watch in 2020, PMID: 31847708

MASP2 levels are elevated in thrombotic microangiopathies: association with microvascular endothelial cell injury and suppression by anti-MASP2 antibody narsoplimab, PMID: 32681658

Inhibition of the Lectin Pathway of the Complement System as a Novel Approach in the Management of IgA Vasculitis-Associated Nephritis, PMID: 32721954

Lectin Pathway Mediates Complement Activation by SARS-CoV-2 Proteins, PMID: 34290717

Transplant-associated thrombotic microangiopathy: theoretical considerations and a practical approach to an unrefined diagnosis, PMID: 33875812

Document Download

Research Grade Narsoplimab.pdf