Catalog No.
YHJ54401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg10-Pro167
Predicted molecular weight
20.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H171
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNA-dependent activator of IFN-regulatory factors, DLM1, ZBP1, C20orf183, Z-DNA-binding protein 1, DAI, Tumor stroma and activated macrophage protein DLM-1
Z-Form Stabilization By The Zα Domain Of Adar1p150 Has Subtle Effects On A-To-I Editing., PMID:40502085
Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics., PMID:40425585
A viral necrosome mediates direct RIPK3 activation to promote inflammatory necroptosis., PMID:40424123
PANoptosis as a Two-Edged Sword in Colorectal Cancer: A Pathogenic Mechanism and Therapeutic Opportunity., PMID:40422233
Virus-specific host responses and gene signatures following infection with major SARS-CoV-2 variants of concern: role of ZBP1 in viral clearance and lung inflammation., PMID:40416961
Investigating the role of necroptosis in the immunological microenvironment of periodontitis., PMID:40402323
Reduction of D2 receptors on microglia leads to ZBP1-mediated PANoptosis of mPFC in Parkinson's disease depression mice., PMID:40367691
Caspase-1-licensed pyroptosis drives dsRNA-mediated necroptosis and dampens host defense against bacterial pneumonia., PMID:40359428
Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease., PMID:40359032
Licochalcone B attenuates pulmonary fibrosis via inhibiting ZBP1-dependent PANoptosis., PMID:40350052
ZBP1 synchronized with periodontopathogenesis as the essential pattern recognition receptor., PMID:40349992
Zn2+ regulates mitochondrial DNA efflux to inhibit AIM2-mediated ZBP1-PANoptosome pathway and alleviate septic myocardial injury., PMID:40348119
Costunolide: Targeting endothelial cell PANoptosis to mitigate lung injury in acute pancreatitis mice., PMID:40318531
Splicing stress-driven cell death via Z-form nucleic acids., PMID:40315823
The extract of chrysanthemum flos mitigates post-stroke sarcopenia by inhibiting PANoptosis and restoring muscle homeostasis., PMID:40311590
Porphyromonas gingivalis induces Zbp1-mediated macrophages PANoptosis in periodonitis pathophysiology., PMID:40307566
TIPE2 Alleviates Sepsis-induced Lung Injury By Inhibiting PANoptosis in Murine Alveolar Macrophages., PMID:40299241
Myeloid deficiency of Z-DNA binding protein 1 restricts septic cardiomyopathy via promoting macrophage polarisation towards the M2-subtype., PMID:40289345
Roles of PANoptosis and related genes in acute liver failure: neoteric insight from bioinformatics analysis and animal experiment verification., PMID:40274384
ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition., PMID:40267921
ZBP1 senses splicing aberration through Z-RNA to promote cell death., PMID:40267920
Mitochondrial DNA signals driving immune responses: Why, How, Where?, PMID:40264103
Investigation of PANoptosis pathway in age-related macular degeneration triggered by Aβ1-40., PMID:40251333
Inflammation-driven biomimetic nano-polyphenol drug delivery system alleviates severe acute pancreatitis by inhibiting macrophage PANoptosis and pancreatic enzymes oversecretion., PMID:40210149
Nd:YAG1064nm laser functions against Sporothrix globosa by inducing PANoptosis via the regulation of ZBP1-induced PANoptosome activation., PMID:40207151
ADAR1 p150 prevents HSV-1 from triggering PKR/eIF2α-mediated translational arrest and is required for efficient viral replication., PMID:40198737
The critical role of the ZBP1-NINJ1 axis and IRF1/IRF9 in ethanol-induced cell death, PANoptosis, and alcohol-associated liver disease., PMID:40161842
KLX ameliorates liver cancer progression by mediating ZBP1 transcription and ubiquitination and increasing ZBP1-induced PANoptosis., PMID:40148674
Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites., PMID:40138774
Panoptosis Targets the Mechanism of PRDX1 Involvement in Acute Myocardial Infarction via ZBP1., PMID:40114419
Artemetin targets the ABCG2/RAB7A axis to inhibit mitochondrial dysfunction in asthma., PMID:40088742
Relating the molecular phenotype of ulcerative colitis to the clinical course., PMID:40064933
Ischemia-reperfusion injury induces ZBP1-dependent PANoptosis in endothelial cells., PMID:40057207
Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity., PMID:40053607
Decoding Allergenicity Modulation in Cold Argon Plasma-Treated Casein: A Multi-Omics Exploration., PMID:40048467
Coronavirus endoribonuclease antagonizes ZBP1-mediated necroptosis and delays multiple cell death pathways., PMID:40035769
Elevated levels of IRF1 and CASP1 as pyroptosis-related biomarkers for intestinal epithelial cells in Crohn's disease., PMID:40018047
Targeted Degradation of ZBP1 with Covalent PROTACs for Anti-Inflammatory Treatment of Infections., PMID:40013409
RIPK1 is required for ZBP1-driven necroptosis in human cells., PMID:39982916
Environmental high temperature induced cartilage damage through triggering programmed necrosis mediated by producing left-handed DNA., PMID:39955869
Network pharmacology and experimental verification in vivo reveal the mechanism of Zhushao Granules against ulcerative colitis., PMID:39953430
Mebendazole induces ZBP-1 mediated PANoptosis of acute myeloid leukemia cells by targeting TUBA1A and exerts antileukemia effect., PMID:39952321
The origin and evolution of necroptosis signaling pathway in metazoa., PMID:39947503
Ochratoxin A induces lung cell PANoptosis through activation of the AIM 2 inflammasome., PMID:39938165
Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells., PMID:39908265
Korean Red ginseng enhances ZBP1-mediated cell death to suppress viral protein expression in host defense against Influenza A virus., PMID:39895072
G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration., PMID:39883578
Characterizing temporal and global host innate immune responses against SARS-CoV-1 and -2 infection in pathologically relevant human lung epithelial cells., PMID:39874350
ZBP1-mediated PANoptosis is a crucial lethal form in diverse keratinocyte death modalities in UVB-induced skin injury., PMID:39863598
The Innate Immune Sensor Zbp1 Mediates Central Nervous System Inflammation Induced by Angiostrongylus Cantonensis by Promoting Macrophage Inflammatory Phenotypes., PMID:39853924
For research use only. Not for human or drug use.
