Catalog No.
YHJ50701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys262-Leu507
Predicted molecular weight
29.22 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BXM7
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PINK1, BRPK, Serine/threonine-protein kinase PINK1, mitochondrial, PTEN-induced putative kinase protein 1
Mitochondrial fumarate inhibits Parkin-mediated mitophagy., PMID:40505663
PINK1 suppresses malignant phenotypes in esophageal squamous cell carcinoma., PMID:40490793
Baoshentongluo Formula relieves podocyte injury in diabetic kidney disease through regulating mitophagy via PINK1/Parkin signaling pathway., PMID:40487763
An environmentally relevant concentration of 6-PPD quinone inhibits two types of mitophagy to cause mitochondrial dysfunction and lifespan reduction in Caenorhabditis elegans., PMID:40485513
Dexmedetomidine improves septic acute kidney injury by inhibiting inflammation and oxidative stress through the activation of the Pink1/Park2 autophagy pathway., PMID:40485166
Propofol-mediated inhibition of ovarian function by mitophagy over-activation via TGF-β1/SMAD2/3 signaling pathway., PMID:40480431
Parkin-dependent ubiquitination of TAX1BP1 directs efficient autophagic removal of defective mitochondria., PMID:40475537
The Developing Retina Undergoes Mitochondrial Remodeling via PINK1/PRKN-dependent Mitophagy., PMID:40472989
Exercise training exerts beneficial effects on Alzheimer's disease through multiple signaling pathways., PMID:40469843
SFXN1 promotes bladder cancer metastasis by restraining PINK1-dependent mitophagy., PMID:40468051
The Role of Kinases in Neurodegenerative Diseases: From Pathogenesis to Treatment., PMID:40464332
[Molecular mechanism of Siwu Decoction in treating premature ovarian insufficiency based on mitophagy pathway modulated and mediated by estrogen receptor subtype]., PMID:40461227
Proteomics based discovery of Salvia miltiorrhiza Bunge treating Parkinson's disease through the PINK1/Parkin pathway., PMID:40456474
PINK1/Parkin-based live-cell quantitative FRET imaging for mitophagy drug screening., PMID:40451779
Whey protein hydrolysate alleviated acetaminophen-induced hepatocyte pyroptosis by activating mitophagy., PMID:40451585
Involvement of the PINK1/Parkin signaling pathway in 4-vinylcyclohexene diepoxide-induced ovary toxicity in rats., PMID:40451534
The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets., PMID:40446800
Vitexin alleviates cerebral ischemia/reperfusion injury by regulating mitophagy via the SIRT1/PINK1/Parkin pathway., PMID:40441663
Lichong Decoction represses colorectal cancer progression via inhibiting the PINK1/Parkin pathway regulated by Rab27B., PMID:40441460
Marsdenia tenacissima extract accelerates ferroptosis of osteosarcoma cells by upregulating HO-1 and activating mitophagy., PMID:40441459
Hyperbaric oxygen therapy attenuates carbon monoxide-induced lung injury by restoring mitochondrial dynamics and suppressing Pink1/Parkin-mediated mitophagy., PMID:40441279
Dl-3-n-Butylphthalide Alleviates Cognitive Impairment in Chronic Cerebral Hypoperfusion: Associations with Mitochondrial Permeability Transition Pore Closure and Suppression of Excessive Mitophagy., PMID:40440567
Impaired Mitophagy Contributes to Pyroptosis in Sarcopenic Obesity Zebrafish Skeletal Muscle., PMID:40431451
Low Fluoride Regulates Macrophage Polarization Through Mitochondrial Autophagy Mediated by PINK1/Parkin Axis., PMID:40427540
The Role of N6-Methyladenosine (m6A) RNA Modification in the Pathogenesis of Parkinson's Disease., PMID:40427510
Paxilline derived from an endophytic fungus of Baphicacanthus cusia alleviates hepatocellular carcinoma through autophagy-mediated apoptosis., PMID:40425675
Icariin mitigates depressive-like behavior in rats by regulating mitochondrial function., PMID:40425078
Ketogenic diet attenuates microglia-mediated neuroinflammation by inhibiting NLRP3 inflammasome activation via HDAC3 inhibition to activate mitophagy in experimental autoimmune encephalomyelitis., PMID:40421817
T cell responses towards PINK1 and α-synuclein are elevated in prodromal Parkinson's disease., PMID:40419563
Human endogenous retrovirus W family envelope protein (ERVWE1) regulates macroautophagy activation and micromitophagy inhibition via NOXA1 in schizophrenia., PMID:40419114
A heterozygous variation of PINK1 is potentially associated with essential tremor in a Chinese family., PMID:40418408
Endoplasmic reticulum tubule junctions are sites of autophagy., PMID:40415242
Chronic mild stress disrupts mitophagy and mitochondrial status in rat frontal cortex., PMID:40410878
Ginsenoside Rh1 attenuates chondrocyte senescence and osteoarthritis via AMPK/PINK1/Parkin-mediated mitophagy., PMID:40409109
Brevilin A, a novel BNIP3 inhibitor suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss via impairing mitophagy and mitochondrial metabolism., PMID:40408943
PINK1-mediated mitochondrial autophagy protects lens epithelial cells by reducing ROS and apoptosis., PMID:40398710
Enterovirus 71 Induces Mitophagy via PINK1/Parkin Signaling Pathway to Promote Viral Replication., PMID:40396408
PINK1/PARKIN-mediated mitophagy inhibits the interferon response and promotes viral replication during Pseudorabies virus infection., PMID:40395521
Targeting Lp-PLA2 inhibits profibrotic monocyte-derived macrophages in silicosis through restoring cardiolipin-mediated mitophagy., PMID:40389600
Cold storage effects on mitochondrial bioenergetics and protein expression in human mesenchymal stromal cells., PMID:40380957
OGT-mediated O-GlcNAc of PINK1 promotes the progression of obesity-related hypertension via regulating mitophagy., PMID:40380818
Magnoflorine alleviates nonalcoholic fatty liver disease by modulating lipid metabolism, mitophagy and inflammation., PMID:40378915
Tollip deficiency enhances mitophagy and reduces STING activation in influenza A virus-infected mice., PMID:40375803
PINK1 deficiency alleviates bleomycin-induced pulmonary fibrosis in mice., PMID:40373838
[Regulatory effect of electroacupuncture at "Neiguan" (PC6) on mitochondrial autophagy during the ischemia and reperfusion phases in rats with myocardial ischemia-reperfusion injury]., PMID:40369922
PINK1 activation by MTK458 ameliorates neurological impairments and pyroptosis after intracerebral hemorrhage in mice., PMID:40368226
The role of dopaminergic medication and specific pathway alterations in idiopathic and PRKN/PINK1-mediated Parkinson's disease., PMID:40367158
Isolation and Characterization of Earthworm Peptides with Neuroprotective Effects in Parkinson's Disease Models., PMID:40363759
Vital Role of PINK1/Parkin-Mediated Mitophagy of Pulmonary Epithelial Cells in Severe Pneumonia Induced by IAV and Secondary Staphylococcus aureus Infection., PMID:40362402
For research use only. Not for human or drug use.
