Catalog No.
YHJ42901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val21-Thr160
Predicted molecular weight
17.95 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99075
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DTR, DT-R, DTS, HEGFL, HB-EGF, HBEGF, Proheparin-binding EGF-like growth factor, Diphtheria toxin receptor
PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine Resistance., PMID:40463196
Embryo-derived human chorionic gonadotropin promotes human decidualization through activating epithelial prostaglandin F2α secretion., PMID:40398806
Receptor-mediated transcytosis of nanobodies targeting the heparin-binding EGF-like growth factor in human blood-brain barrier models., PMID:40393531
Interleukin-1β Stimulates Matrix Metalloproteinase 10 Secretion: A Possible Mechanism in Trophoblast-Dependent Spiral Artery Remodeling., PMID:40326797
Fibroblast EGFR signaling mediates ricin toxin-induced acute lung injury via EGR1/CXCL1 axis., PMID:40317338
Exogenous administration of heparin-binding epidermal growth factor-like growth factor improves erectile function in mice with bilateral cavernous nerve injury., PMID:40247713
In Vitro, Ex Vivo, Instrumental, and Clinical Assessment of a Novel Anti-aging Serum Targeting Oxidative Stress., PMID:40178310
[Fetal Heart Failure: Exploring Diagnosis and Treatment Strategies]., PMID:40175147
Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model., PMID:40156268
Associations of ANGPT2 expression and its variants (rs1868554 and rs7825407) with multiple myeloma risk and outcome., PMID:40115011
Pd Icosahedral Nanoparticles Promote Skin Wound Healing by Enhancing SP1-HBEGF Axis-Mediated Keratinocytes Proliferation., PMID:40093544
The impact of ERN1 endoribonuclease activity inhibition on TOB1, HBEGF, and TWIST1 genes expression in U87MG glioblastoma cells., PMID:40073406
Universal First-Trimester Screening Biomarkers for Diagnosis of Preeclampsia and Placenta Accreta Spectrum., PMID:40001531
APOE- ε4-induced Fibronectin at the blood-brain barrier is a conserved pathological mediator of disrupted astrocyte-endothelia interaction in Alzheimer's disease., PMID:39975303
Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a "hit-and-run" paradigm., PMID:39960839
Exploring shared pathogenesis of multiple myeloma and osteoporosis via bioinformatic analysis., PMID:39943780
MiR-5586-5p Suppresses Hypoxia-induced Angiogenesis Through Multiple Targeting of HIF-1α, HBEGF and ADAM17 in Breast Cancer., PMID:39890164
Single-cell RNA sequencing identifies endothelial-derived HBEGF as promoting pancreatic beta cell proliferation in mice via the EGFR-Kmt5a-H4K20me pathway., PMID:39694915
SPTLC2 drives an EGFR-FAK-HBEGF signaling axis to promote ovarian cancer progression., PMID:39645550
Are hypoxia-related proteins associated with the invasiveness of glandular odontogenic cysts? A multicenter study., PMID:39644628
Brain multi-omic Mendelian randomisation to identify novel drug targets for gliomagenesis., PMID:39565278
Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters in collective cell migration of epithelial cells., PMID:39546398
Evaluation of the effect of an amniotic membrane derived bio-nano product (LifeCell) on human endometrial cells proliferation and gene expression: An in-vitro study., PMID:39489031
Molybdenum interferes with MMPs/TIMPs expression to reduce the receptivity of porcine endometrial epithelial cells., PMID:39486568
Heparin-binding EGF-like growth factor via miR-126 controls tumor formation/growth and the proteolytic niche in murine models of colorectal and colitis-associated cancers., PMID:39419989
Lactate-Induced HBEGF Shedding and EGFR Activation: Paving the Way to a New Anticancer Therapeutic Opportunity., PMID:39329717
Development of a Proteomic Workflow for the Identification of Heparan Sulphate Proteoglycan-Binding Substrates of ADAM17., PMID:39318062
Staphylococcus epidermidis augments human β-defensin-3 synthesis through the transforming growth factor alpha-epidermal growth factor receptor cascade., PMID:39306536
Stretch-induced hepatic endothelial mechanocrine promotes hepatocyte proliferation., PMID:39250438
Bu-Shen-Ning-Xin decoction ameliorates premature ovarian insufficiency by suppressing oxidative stress through rno_circRNA_012284/rno_miR-760-3p/HBEGF pathway., PMID:39126922
In vitro, ex vivo, instrumental and clinical evaluation of a topical cream on the signs of periorbital ageing., PMID:39119663
Genetically Predicted Vascular Proteins and Risk of Intracranial Aneurysms: A Mendelian Randomization Study., PMID:39066975
Establishment and Characterization of Salivary Gland-Specific Injury in Transgenic Mice Model., PMID:39047709
Heparin-binding epidermal growth factor-like growth factor improves erectile function in streptozotocin-induced diabetic mice., PMID:39033084
B7-H3 enhances colorectal cancer progression by regulating HB-EGF via HIF-1α., PMID:38989423
HB-EGF activates EGFR to induce reactive neural stem cells in the mouse hippocampus after seizures., PMID:38977310
LMWH prevents thromboinflammation in the placenta via HBEGF-AKT signaling., PMID:38941535
Knockout Genes in Bowel Anastomoses: A Systematic Review of Literature Outcomes., PMID:38929776
A Bioswitchable MiRNA Delivery System: Tetrahedral Framework DNA-Based miRNA Delivery System for Applications in Wound Healing., PMID:38885077
Exploration of the Shared Gene Signatures and Molecular Mechanisms between Chronic Bronchitis and Antineutrophil Cytoplasmic Antibody-associated Glomerulonephritis: Evidence from Transcriptome Data., PMID:38847168
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) activates p38 to affect pulmonary fibrosis., PMID:38798743
Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model., PMID:38746443
Novel IL-4/HB-EGF-dependent crosstalk between eosinophils and macrophages controls liver regeneration after ischaemia and reperfusion injury., PMID:38724220
Protein disulfide isomerase-mediated transcriptional upregulation of Nox1 contributes to vascular dysfunction in hypertension., PMID:38690903
Can the HB-EGF/EGFR pathway restore injured neurons?, PMID:38680125
Identification of Critical Genes Differentiating Stable and Unstable Atherosclerotic Plaques: A Bioinformatic and Computational Analysis., PMID:38639275
Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence., PMID:38499654
Pkd1l1-deficiency drives biliary atresia through ciliary dysfunction in biliary epithelial cells., PMID:38460793
The Multiple Functions of HB-EGF in Female Reproduction and Related Cancer: Molecular Mechanisms and Targeting Strategies., PMID:38424408
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology., PMID:38409259
For research use only. Not for human or drug use.
