Catalog No.
YHJ30901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu6-Asp263
Predicted molecular weight
31.60 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WXH0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nuclear envelope spectrin repeat protein 2, KIAA1011, Protein NUANCE, KASH domain-containing protein 2, Nesprin-2, Syne-2, NUA, SYNE2, Synaptic nuclear envelope protein 2, Nucleus and actin connecting element protein, KASH2
Nesprin-2 contains BH3-like motifs that can promote cell death., PMID:40461467
ATXN2L primarily interacts with NUFIP2, the absence of ATXN2L results in NUFIP2 depletion, and the ATXN2-polyQ expansion triggers NUFIP2 accumulation., PMID:40220918
Global profiling of alternative splicing in non-small cell lung cancer reveals novel histological and population differences., PMID:39789165
Apoptosis-induced translocation of nesprin-2 from the nuclear envelope to mitochondria is associated with mitochondrial dysfunction., PMID:39402980
Unraveling the nexus of nesprin in dilated cardiomyopathy: From molecular insights to therapeutic prospects., PMID:39396640
Common SYNE2 Genetic Variant Associated With Atrial Fibrillation Lowers Expression of Nesprin-2α1 With Downstream Effects on Nuclear and Electrophysiological Traits., PMID:39355904
Genes Co-Expressed with ESR2 Influence Clinical Outcomes in Cancer Patients: TCGA Data Analysis., PMID:39201394
Nesprin-2 coordinates opposing microtubule motors during nuclear migration in neurons., PMID:39115447
Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in the cardiomyocyte sarcomere., PMID:38569934
Genome-wide detection of m6A-associated SNPs in atrial fibrillation pathogenesis., PMID:37304952
Role of Nesprin-2 and RanBP2 in BICD2-associated brain developmental disorders., PMID:36930595
Quantitative Proteomics Explore the Potential Targets and Action Mechanisms of Hydroxychloroquine., PMID:36014414
Integrative Analyses Identify Potential Key Genes and Calcium-Signaling Pathway in Familial Atrioventricular Nodal Reentrant Tachycardia Using Whole-Exome Sequencing., PMID:35924220
Proteomic changes involved in water holding capacity of frozen bovine longissimus dorsi muscles based on DIA strategy., PMID:35848392
Accurate age estimation from blood samples of Han Chinese individuals using eight high-performance age-related CpG sites., PMID:35819508
Evaluating the detection ability of a range of epistasis detection methods on simulated data for pure and impure epistatic models., PMID:35180244
Immunization with short peptide particles reveals a functional CD8+ T-cell neoepitope in a murine renal carcinoma model., PMID:34862254
The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair., PMID:34818527
Biallelic SYNE2 Missense Mutations Leading to Nesprin-2 Giant Hypo-Expression Are Associated with Intellectual Disability and Autism., PMID:34573277
Silencing of Nesprin-2 inhibits the differentiation of myofibroblasts from fibroblasts induced by mechanical stretch., PMID:34558192
TWEAKing the Hippocampus: The Effects of TWEAK on the Genomic Fabric of the Hippocampus in a Neuropsychiatric Lupus Mouse Model., PMID:34440346
The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal., PMID:33686165
Roles of the multivalent dynein adaptors BicD2 and RILP in neurons., PMID:33667600
In Silico Inference of Synthetic Cytotoxic Interactions from Paclitaxel Responses., PMID:33499282
Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins., PMID:33472039
Cytoplasmic control of intranuclear polarity by human cytomegalovirus., PMID:32908309
Nesprins are mechanotransducers that discriminate epithelial-mesenchymal transition programs., PMID:32790861
Nesprin-2 Recruitment of BicD2 to the Nuclear Envelope Controls Dynein/Kinesin-Mediated Neuronal Migration In Vivo., PMID:32619477
Genomic characterization of vulvar squamous cell carcinoma., PMID:32591094
A novel SYNE2 mutation identified by whole exome sequencing in a Korean family with Emery-Dreifuss muscular dystrophy., PMID:32184094
Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies., PMID:32109663
Proteins in stool as biomarkers for non-invasive detection of colorectal adenomas with high risk of progression., PMID:31784980
Lack of a Retinal Phenotype in a Syne-2/Nesprin-2 Knockout Mouse Model., PMID:31614616
Nesprin-1-alpha2 associates with kinesin at myotube outer nuclear membranes, but is restricted to neuromuscular junction nuclei in adult muscle., PMID:31578382
Amplification of nuclear deformation of breast cancer cells by seeding on micropatterned surfaces to better distinguish their malignancies., PMID:31398621
Establishment and genomic characterization of gingivobuccal carcinoma cell lines with smokeless tobacco associated genetic alterations and oncogenic PIK3CA mutation., PMID:31164688
SPAG4L/SPAG4Lβ interacts with Nesprin2 to participate in the meiosis of spermatogenesis., PMID:31144711
Accumulation of Progerin Affects the Symmetry of Cell Division and Is Associated with Impaired Wnt Signaling and the Mislocalization of Nuclear Envelope Proteins., PMID:31128203
Amorphous Silicon Oxynitrophosphide-Coated Implants Boost Angiogenic Activity of Endothelial Cells., PMID:31044666
Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging., PMID:30808750
Drug repositioning for dengue haemorrhagic fever by integrating multiple omics analyses., PMID:30679503
Nesprin-2G knockout fibroblasts exhibit reduced migration, changes in focal adhesion composition, and reduced ability to generate traction forces., PMID:30667166
A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3., PMID:30592498
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways., PMID:30429480
Depletion of Nesprin-2 is associated with an embryonic lethal phenotype in mice., PMID:30220251
Analysis of Nesprin-2 Interaction with Its Binding Partners and Actin., PMID:30141036
Analysis of High Molecular Weight Isoforms of Nesprin-1 and Nesprin-2 with Vertical Agarose Gel Electrophoresis., PMID:30141035
Functional analyses of Pericentrin and Syne-2 interaction in ciliogenesis., PMID:30054381
LINC complex-Lis1 interplay controls MT1-MMP matrix digest-on-demand response for confined tumor cell migration., PMID:29934494
STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap., PMID:29844364
For research use only. Not for human or drug use.
