Catalog No.
EHJ10801
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Asn21-Pro242
Predicted molecular weight
28.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6ZMJ4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL34, Interleukin-34, C16orf77, IL-34
The distinct role of IL-34 and IL-35 in gastric cancer., PMID:40416985
Elevated levels of salivary interleukin-34 in patients suffering from Alzheimer's disease., PMID:40389754
CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation., PMID:40387575
Characterization of IL-34 and CSF-1R in Sciaenops ocellatus: IL-34 participates in its anti-bacterial immune responses to Vibrio harveyi infection., PMID:40383499
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Axatilimab in Healthy Japanese Male Participants: Results from a Phase 1, Randomized, Double-Blind, Dose-Escalation Study., PMID:40381116
Interleukin-34-dependent perivascular macrophages promote vascular function in the brain., PMID:40315842
Protein recognition is chiefly mediated by the CDR2 region in TREM2 - an in silico characterization., PMID:40280075
RXFP2-positive mesenchymal stem cells in the antlerogenic periosteum contribute to postnatal development of deer antlers., PMID:40263536
Prognostic role of IL-34 in sepsis and sepsis-induced acute lung injury: preliminary results and future directions., PMID:40176879
Layer-specific molecular signatures of colon anastomotic healing and leakage in mice., PMID:40169980
Resident Macrophages in the Cervical Sympathetic Ganglia Participate in P2Y12 Receptor Mediated Diabetic Cardiac Autonomic Neuropathy., PMID:40146499
New soluble CSF-1R-dimeric mutein with enhanced trapping of both CSF-1 and IL-34 reduces suppressive tumor-associated macrophages in pleural mesothelioma., PMID:40101804
Interleukin-34 orchestrates bone formation through its binding to bone morphogenic proteins., PMID:40083929
IL-34/TREM2 modulates microglia-mediated inflammation and provides neuroprotection in a mouse model of sporadic Alzheimer's disease., PMID:40025720
Mendelian randomization reveals causal relationships between cytokines and male reproductive diseases., PMID:40023096
Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model., PMID:40016767
Identification of IL-34 and Slc7al as potential key regulators in MASLD progression through epigenomic profiling., PMID:39956835
Role of IL-34 in Tumors and Its Application to Regulate Inflammation., PMID:39951014
Intestinal epithelium-derived IL-34 reprograms macrophages to mitigate gastrointestinal tract graft-versus-host disease., PMID:39937882
Decoding the cytokine code for heart failure based on bioinformatics, machine learning and Bayesian networks., PMID:39909085
Development of antigen-capture enzyme-linked immunoassay for Chicken Interleukin-34., PMID:39900196
IL-34 aggravates myocardial ischemia-reperfusion injury by upregulating the HMGB1-IL-17A-IL-6 axis through the JAK signaling pathway., PMID:39883639
Genetically engineered bacteria expressing IL-34 alleviate DSS-induced experimental colitis by promoting tight junction protein expression in intestinal mucosal epithelial cells., PMID:39864284
Characterizing the diabetes-induced pathological changes of the mouse lung by single-cell RNA sequencing., PMID:39832739
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands., PMID:39789647
Identification of potential therapeutic targets for Alzheimer's disease from the proteomes of plasma and cerebrospinal fluid in a multicenter Mendelian randomization study., PMID:39755304
Microglia-like cells from patient monocytes demonstrate increased phagocytic activity in probable Alzheimer's disease., PMID:39732446
Diversity of Microglia-Derived Molecules with Neurotrophic Properties That Support Neurons in the Central Nervous System and Other Tissues., PMID:39683685
Higher Intraocular Levels of Inflammatory Factors are Related to Retinal Vascular and Neurodegeneration in Myopic Retinopathy., PMID:39677296
Squamous cell carcinoma is associated with reduced IL34 expression, alterations in the Langerhans cell antigen-processing-presentation machinery and poor patient survival., PMID:39619016
Recombinant IL-34 alleviates bacterial enteritis in Megalobrama amblycephala by strengthening the intestinal barrier., PMID:39592038
Characterization of two novel MCSFR paralogues in rainbow trout Oncorhynchus mykiss: New insights into the molecular mechanism underlying macrophage differentiation and modulation in fish., PMID:39571632
Is there a relationship between CSF Interleukin 34 Level and clinicoradiological activity and IgG index in patients with MS?, PMID:39571220
Inflammatory and cardiac biomarkers in pulmonary arterial hypertension: The prognostic role of IL-34., PMID:39488026
TAM-ing the beast with IL-34 blockade., PMID:39485858
Bromodomain-Containing 4 Is a Positive Regulator of Interleukin-34 Production in the Gut., PMID:39451216
AKAP12 positive fibroblast determines immunosuppressive contexture and immunotherapy response in patients with TNBC by promoting macrophage M2 polarization., PMID:39448199
Two homologous genes encoding interleukin (IL)-34 in the common carp (Cyprinus carpio L.): Roles in inflammatory modulation and anti-bacterial defense., PMID:39389173
Expression of Macrophage Colony-Stimulating Factor CSF-1 in Spinal Cord Neurons in Mice with Experimental Autoimmune Encephalomyelitis., PMID:39352675
Interleukin-34-orchestrated tumor-associated macrophage reprogramming is required for tumor immune escape driven by p53 inactivation., PMID:39321806
Time series analysis combined with transcriptome sequencing to explore characteristic genes and potential molecular mechanisms associated with ultrasound-guided microwave ablation of glioma., PMID:39317933
Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands., PMID:39315272
The effects of GCRV on various tissues of grass carp (Ctenopharyngodon idella) and identification of differential interferon-stimulating genes (ISGs) through muscle transcriptome analysis., PMID:39208574
Macrophage Colony Stimulating Factor (M-CSF) and Interleukin-34 (IL-34) Expression in Canine Osteosarcoma in the Context of the Tumour Immune Microenvironment., PMID:39164469
Enhanced cytokine signaling and ferroptosis defense interplay initiates obesity-associated pancreatic ductal adenocarcinoma., PMID:39127339
Clodronate liposome treatment contributes to the nerve regeneration in corneal nerve involvement of diabetic mice., PMID:39111878
Profiles of cytokines in patients with antineutrophil cytoplasmic antibody-associated vasculitis., PMID:39108259
IL-34 and its receptors as predictors of brain metastasis and prognosis in lung adenocarcinoma: Unveiling insights through bioinformatic and immunohistochemical investigations., PMID:39055827
Inflammatory profile of patients with different weight diagnoses and similar periodontal condition: A systematic review., PMID:38988953
The role of serum interleukins in Cancer: A Multi-center Mendelian Randomization study., PMID:38901247
For research use only. Not for human or drug use.
