Catalog No.
YHG85601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser123
Predicted molecular weight
16.44 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14653
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IRF-3, IRF3, Interferon regulatory factor 3
Targeting USP18 overcomes acquired resistance in hepatocellular carcinoma by regulating NCOA4 deISGylation and ferroptosis., PMID:40514377
Black carp STAT2 enhances IRF3-mediated antiviral signaling by regulating its ubiquitination and improving its nuclear translocation., PMID:40513786
HERC5 induces podocyte injury in LN by mediated IRF3 ISGylation to promote the production and overactivation of IFN-β in podocytes., PMID:40505230
Premature cell senescence promotes vascular smooth muscle cell phenotypic modulation and resistance to re-differentiation., PMID:40493738
The CARD14sh-BCL10-MALT1 complex regulates MAVS-mediated antiviral response in keratinocytes., PMID:40489607
Getah virus nonstructural protein 2 suppresses interferon-beta production by interrupting interferon regulatory factor 3 activation., PMID:40483467
Regulatory mechanism of viperin in the interferon signaling pathway of large yellow croaker: Characterization of the promoter region., PMID:40482876
The Ran GTPase inhibits SGIV and RGNNV infection by upregulating host immune response in grouper., PMID:40472906
Mitochondria-derived dsRNA-induced stress granules promote IRF3-mediated fibrotic responses., PMID:40463009
Macrophage activation determines muscle wasting in pancreatic cancer., PMID:40442475
Design of an Oral STING Agonist through Intramolecular Hydrogen Bond Ring Mimicking to Achieve Complete Tumor Regression., PMID:40442142
Elucidating the chromatin-driven transcription regulatory networks response to Streptococcus agalactiae infection under low temperature in Nile tilapia., PMID:40441668
Late-Stage Activation of Toll-like receptor 3 Alleviates Cognitive Impairment and Neuropathology in an Alzheimer's Disease Mouse Model., PMID:40437286
Mechanisms of Immune Evasion of West Nile Virus., PMID:40432246
Stromal Interferon Regulatory Factor 3 Can Antagonize Human Papillomavirus Replication by Supporting Epithelial-to-Mesenchymal Transition., PMID:40431610
Mitochondrial Antiviral Signaling Protein Activation by Retinoic Acid-Inducible Gene I Agonist Triggers Potent Antiviral Defense in Umbilical Cord Mesenchymal Stromal Cells Without Compromising Mitochondrial Function., PMID:40429828
RSV-Induced Regulation of DC via H3K4 Demethylase KDM5b., PMID:40417973
[Cucurbitacin B alleviates skin lesions and inflammation in a psoriasis mouse model by inhibiting the cGAS-STING signaling pathway]., PMID:40415622
Unveiling EXOC4/SEC8: a key player in enhancing antiviral immunity by inhibiting the FBXL19-STING1-SQSTM1 signaling axis., PMID:40413753
Anti-inflammatory effects of Elsholtzia ciliata extract on Poly I:C-treated RAW264.7 cells., PMID:40412777
Zebrafish ARRDC3a negatively regulates type I IFN production by targeting the RLR signaling pathway., PMID:40409698
The viral early protein 4 of human papillomavirus type 16 suppresses innate antiviral immunity., PMID:40409624
GADD45G operates as a pathological sensor orchestrating reactive gliosis and neurodegeneration., PMID:40409253
The activation of cGAS-STING pathway promotes the epithelial-mesenchymal transition and inflammation in intrauterine adhesion., PMID:40409098
Oligoadenylate synthetase 1a suppresses prion infection through binding to cellular prion protein., PMID:40406853
Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway., PMID:40406492
Icariin alleviates cognitive dysfunction by reducing neuroinflammation via the cGAS-STING pathway., PMID:40403897
Ellipticine derivatives as Toll-like receptor 3 inhibitor for treating acute hepatitis., PMID:40403645
MPXV infection activates cGAS-STING signaling and IFN-I treatment reduces pathogenicity of mpox in CAST/EiJ mice and rhesus macaques., PMID:40398389
Zebrafish fkbp5 attenuates antiviral innate immunity by autophagic degradation of transcription factor irf7., PMID:40391431
Electroacupuncture Improves Intestinal Ischemia/Reperfusion Injury via cGAS-STING Pathway., PMID:40391398
Design of Potent Small-Molecule Stimulator of Interferon Gene Inhibitor and Stimulator of Interferon Gene Mutant-Specific Degrader., PMID:40386971
Inflammatory signaling pathways in pancreatic β-cell: New insights into type 2 diabetes pathogenesis., PMID:40378943
cGAS-STING Pathway's Impact on Intestinal Barrier., PMID:40377214
STK39 inhibits antiviral immune response by inhibiting DCAF1-mediated PP2A degradation., PMID:40370558
Reannotation of cancer mutations based on expressed RNA transcripts reveals functional non-coding mutations in melanoma., PMID:40359938
Zebrafish TRIM2a promotes virus replication via ubiquitination of IRF3 and autophagic cargo receptor p62., PMID:40359380
[Buzhong Yiqi Decoction alleviates immune injury of autoimmune thyroiditis in NOD.H-2~(h4)mice via c GAS-STING signaling pathway]., PMID:40350879
Black carp OTUD1 negatively regulates antiviral innate immunity via deubiquitination and degradation of IRF3/7., PMID:40350101
Singapore grouper iridovirus VP018 abrogates the interferon response by targeting STING-TBK1-IRF3 axis., PMID:40339868
The C-terminal nsP1a protein of porcine astrovirus antagonizes interferon beta production by targets MAVS and IRF3 signaling., PMID:40339257
Electroacupuncture intervention relieves pain by stimulating the STING/IFN-I pathway in rat models of cancer-induced bone pain., PMID:40331681
Human papillomavirus E1 proteins inhibit RIG-I/MDA5-MAVS, TLR3-TRIF, cGAS-STING, and JAK-STAT signaling pathways to evade innate antiviral immunity., PMID:40330484
RBM39 shapes innate immunity by controlling the expression of key factors of the interferon response., PMID:40330464
STING-∆C, a novel splice isoform of STING, inhibits DNA virus-induced innate immunity and autophagy., PMID:40319960
A strain of Lactobacillus plantarum from piglet intestines enhances the anti-PoRV effect via the STING-IFN-I pathway., PMID:40319282
PWWP3A disrupts the assembly of VISA/MAVS signalosome to inhibit innate immune response against RNA viruses., PMID:40312484
Selective BCL-2 inhibitor triggers STING-dependent antitumor immunity via inducing mtDNA release., PMID:40300857
Palmitoyl-transferase 3 promotes mitochondrial antiviral signaling protein degradation by modulating its ubiquitination., PMID:40300684
Foot-and-mouth disease virus 3C protein acts as an anti-inflammatory factor by mediating degradation of TLR4 signaling various molecules via caspase activity., PMID:40300413
For research use only. Not for human or drug use.
