Catalog No.
YHF93601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro190-Asp472
Predicted molecular weight
32.97 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q02388
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Long-chain collagen, Collagen alpha-1(VII) chain, COL7A1, LC collagen
Safe and Efficacious Permanent Removal of Large COL7A1 Exons for Gene Reframing as a Reliable Therapeutic Strategy for Recessive Dystrophic Epidermolysis Bullosa., PMID:40432605
Multidimensional Evidence Chain of Nutritional Impact on Digestive System Tumors: Integration of Mendelian Randomization Causal Inference, NHANES Epidemiological Data, and Transcriptomic Analysis., PMID:40415396
The Spectrum of Epidermolysis Bullosa in KwaZulu-Natal, South Africa., PMID:40369731
Paw Skin as a Translational Model for Investigating Fibrotic and Inflammatory Wound Healing Defects in Recessive Dystrophic Epidermolysis Bullosa., PMID:40362519
Genetic insight into lung neuroendocrine tumors: Notch and Wnt signaling pathways as potential targets., PMID:40361150
Collagen VII Is Associated with Airway Remodeling, Honeycombing, and Fibroblast Foci in Usual Interstitial Pneumonia/Idiopathic Pulmonary Fibrosis., PMID:40311757
Identification of Specific Biomarkers for Anaplastic Thyroid Carcinoma Through Spatial Transcriptomic and Immunohistochemical Profiling., PMID:40244468
Porous Silicon Nanoneedles Efficiently Deliver Adenine Base Editor to Correct a Recurrent Pathogenic COL7A1 Variant in Recessive Dystrophic Epidermolysis Bullosa., PMID:40072288
Phenotypic Characteristics of a Patient Cohort With Recessive Dystrophic Epidermolysis Bullosa and the Pathogenic Variant c.7485+5G>A in Intron 98 of COL7A1., PMID:40013374
Spatial transcriptomics reveals prognostically LYZ+ fibroblasts and colocalization with FN1+ macrophages in diffuse large B-cell lymphoma., PMID:39998673
A pathogenic COL7A1 variant highlights semi-dominant inheritance in dystrophic epidermolysis bullosa., PMID:39905456
Repurposing diacerein for the treatment of chronic wounds in recessive-dystrophic epidermolysis bullosa patients by modulating matrix metalloproteinase-9 expression., PMID:39853777
Guanidyl-rich highly branched poly(β-amino ester)s for the delivery of dual CRISPR ribonucleoprotein for efficient large DNA fragment deletion., PMID:39837388
Systems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa., PMID:39809737
Functional genotype classification groups distinguish disease severity in recessive dystrophic epidermolysis bullosa., PMID:39790012
Genetic Insights Into Epidermolysis Bullosa: Identification of Novel Variants in Tunisian Patients., PMID:39688128
Novel variants impairing Sp1 transcription factor binding in the COL7A1 promoter cause mild cases of recessive dystrophic epidermolysis bullosa., PMID:39639148
Clinical and Genetic Findings in Patients With Palmoplantar Keratoderma., PMID:39630431
A homozygous nonsense mutation identified in COL7A1 in a family with autosomal recessive dystrophic epidermolysis bullosa., PMID:39628969
Collagen Type VII (COL7A1) as a Longevity Mediator in Caenorhabditis elegans: Anti-Aging Effects on Healthspan Extension and Skin Collagen Synthesis., PMID:39428402
Current Status of Biomedical Products for Gene and Cell Therapy of Recessive Dystrophic Epidermolysis Bullosa., PMID:39408598
Splice modulation strategy applied to deep intronic variants in COL7A1 causing recessive dystrophic epidermolysis bullosa., PMID:39159368
Identification of novel small molecule-based strategies of COL7A1 upregulation and readthrough activity for the treatment of recessive dystrophic epidermolysis bullosa., PMID:39152155
Identification of hub genes and key modules in laryngeal squamous cell carcinoma., PMID:39145051
Dystrophic epidermolysis bullosa characterized by mucosal lesions in a Chinese familial case with a novel compound heterozygous mutation of COL7A1., PMID:39039807
Targeted panel sequencing of pharmacogenes and oncodrivers in colorectal cancer patients reveals genes with prognostic significance., PMID:39030589
Anti-photoaging effect and the mechanism of Coreopsis tinctoria okanin against UVB-induced skin damage in mice., PMID:39024749
A scalable and cGMP-compatible autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa., PMID:38992003
Online, home-based dystrophic epidermolysis bullosa registry., PMID:38943317
Histological and molecular restoration of type VII collagen in Recessive dystrophic epidermolysis bullosa mouse skin by topical injection of keratinocyte-like cells differentiated from human adipose-derived mesenchymal stromal cells., PMID:38876908
Two sisters with recessive dystrophic epidermolysis bullosa caused by novel variants in COL7A1., PMID:38840153
Good clinical response to cemiplimab in a young patient with locally advanced cutaneous squamous cell carcinoma on preexisting recessive dystrophic epidermolysis bullosa., PMID:38808531
Twin Prime Editing Mediated Exon Skipping/Reinsertion for Restored Collagen VII Expression in Recessive Dystrophic Epidermolysis Bullosa., PMID:38763174
Functional genotype-phenotype associations in recessive dystrophic epidermolysis bullosa., PMID:38735484
Practical considerations relevant to treatment with the gene therapy beremagene geperpavec-svdt for dystrophic epidermolysis bullosa., PMID:38724041
Creation and characterization of novel rat model for recessive dystrophic epidermolysis bullosa: Frameshift mutation of the Col7a1 gene leads to severe blistered phenotype., PMID:38722855
Unravelling drivers of cutaneous squamous cell carcinoma in recessive dystrophic epidermolysis bullosa., PMID:38703415
Superior COL7A1 and TGM1 gene expression in difficult-to-transfect skin cell mediated by highly branched poly(β-amino esters) through stepwise fractionation., PMID:38643938
Beyond the Surface: A Narrative Review Examining the Systemic Impacts of Recessive Dystrophic Epidermolysis Bullosa., PMID:38613531
Lipid Nanoparticles Efficiently Deliver the Base Editor ABE8e for COL7A1 Correction in Dystrophic Epidermolysis Bullosa Fibroblasts In Vitro., PMID:38583743
Epidermolysis Bullosa: Two rare case reports of COL7A1 and EBS-GEN SEV KRT14 variants with review of literature., PMID:38580989
Nonsense variant readthrough therapy for epidermolysis bullosa., PMID:38530166
RETRACTED: Exploring the tumor microenvironment: Chemokine-related genes and immunotherapy/chemotherapy response in clear-cell renal cell carcinoma., PMID:38488671
Dominant dystrophic epidermolysis bullosa is associated with glycolytically active GATA3+ T helper 2 cells which may contribute to pruritus in lesional skin., PMID:38477474
On- and off-target effects of paired CRISPR-Cas nickase in primary human cells., PMID:38459694
Self-improving dystrophic epidermolysis bullosa with a novel heterozygous missense variant in the COL7A1 gene in a Taiwanese family., PMID:38415502
Cyclization-enhanced poly(β-amino ester)s vectors for efficient CRISPR gene editing therapy., PMID:38401849
A case of dystrophic epidermolysis bullosa with a rare COL7A1 variant., PMID:38378365
Advantages of whole-exome sequencing over immunomapping in 67 Brazilian patients with epidermolysis bullosa., PMID:38368142
Intravenous gentamicin therapy induces functional type VII collagen in patients with recessive dystrophic epidermolysis bullosa: an open-label clinical trial., PMID:38366625
For research use only. Not for human or drug use.
