Catalog No.
DHC43601
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Humanized
Isotype
IgG4-kappa
Clonality
Monoclonal
Target
C1 esterase, Complement C1s subcomponent, C1S, Complement component 1 subcomponent s
Concentration
3.07 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P09871
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
BIVV009, IPN-009, TNT009, CAS: 2049079-64-1
Clone ID
Sutimlimab
Autoimmune hemolytic anemia, PMID: 30504336
Antibodies to watch in 2020, PMID: 31847708
Inhibition of complement C1s improves severe hemolytic anemia in cold agglutinin disease: a first-in-human trial, PMID: 30559259
New Insights in Autoimmune Hemolytic Anemia: From Pathogenesis to Therapy Stage 1, PMID: 33261023
Novel insights into the treatment of complement-mediated hemolytic anemias, PMID: 31523413
Sutimlimab in Cold Agglutinin Disease, PMID: 33826820
C1s Inhibition by BIVV009 (Sutimlimab) Prevents Complement-Enhanced Activation of Autoimmune Human B Cells In Vitro, PMID: 30635392
A Randomized, First-in-Human, Healthy Volunteer Trial of sutimlimab, a Humanized Antibody for the Specific Inhibition of the Classical Complement Pathway, PMID: 29737533
Inhibition of complement C1s in patients with cold agglutinin disease: lessons learned from a named patient program, PMID: 32176765
2019 ASH Annual Meeting, PMID: 31859224
Cold agglutinin disease: current challenges and future prospects, PMID: 31114413
How I treat cold agglutinin disease, PMID: 33512410
Specific Inhibition of the Classical Complement Pathway Prevents C3 Deposition along the Dermal-Epidermal Junction in Bullous Pemphigoid, PMID: 31229501
Serum complement levels in immune thrombocytopenia: Characterization and relation to clinical features, PMID: 32685889
For research use only. Not for human or drug use.
