Catalog No.
YHE51601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe42-Ile250
Predicted molecular weight
50.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P47869
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GABA(A) receptor subunit alpha-2, GABRA2, Gamma-aminobutyric acid receptor subunit alpha-2
Highlighted gene expression alteration in human pancreatic isolated islets in patients with type 2 diabetes., PMID:40291507
Atp1a2 and Kcnj9 Are Candidate Genes Underlying Sensitivity to Oxycodone-Induced Locomotor Activation and Withdrawal-Induced Anxiety-Like Behaviors in C57BL/6 Substrains., PMID:39801366
N-Demethylsinomenine Relieves Neuropathic Pain in Male Mice Mainly via Regulating α2-Subtype GABAA Receptors., PMID:39749638
A novel de novo GABRA2 gene missense variant causing developmental epileptic encephalopathy in a Chinese patient., PMID:39737842
Genomic factors associated with substance use disorder relapse: A critical review., PMID:39553284
Trans-Ferulic acid reduces the sedative activity of diazepam in thiopental sodium-induced sleeping mice: A potential GABAergic transmission., PMID:39547315
Multi-target Mechanisms of Si-Ni-San on Anxious Insomnia: An Example of Network-pharmacology and Molecular Docking Analysis., PMID:39410900
Flavonoids from mulberry leaves exhibit sleep-improving effects via regulating GABA and 5-HT receptors., PMID:39374877
Integrated proteomic and glycoproteomic analysis reveals heterogeneity and molecular signatures of brain metastases from lung adenocarcinomas., PMID:39341452
5,7,3',4',5'-Pentamethoxyflavone, a Flavonoid Monomer Extracted From Murraya paniculata (L.) Jack, Alleviates Anxiety Through the A2AR/Gephyrin/GABRA2 Pathway., PMID:39261011
Sleep-improving effect and the potential mechanism of Morus alba L. on mice., PMID:39255910
Integration analysis of pituitary proteome and transcriptome reveals fertility-related biomarkers in FecB mutant Small Tail Han sheep., PMID:39109077
Hypothalamic and hippocampal transcriptome changes in AppNL-G-F mice as a function of metabolic and inflammatory dysfunction., PMID:39002757
Dynamic regulation of CeA gene expression during acute and protracted abstinence from chronic binge drinking of male and female C57BL/6J mice., PMID:38945280
Characterization of the zebrafish gabra1sa43718/sa43718 germline loss of function allele confirms a function for Gabra1 in motility and nervous system development., PMID:38908344
Selective knockdown of GABAA-α2 subunit in the dorsal dentate gyrus in adulthood induces anxiety, learning and memory deficits and impairs synaptic plasticity., PMID:38858171
Atp1a2 and Kcnj9 are candidate genes underlying sensitivity to oxycodone-induced locomotor activation and withdrawal-induced anxiety-like behaviors in C57BL/6 substrains., PMID:38798314
Impaired GABAergic regulation and developmental immaturity in interneurons derived from the medial ganglionic eminence in the tuberous sclerosis complex., PMID:38714540
Changes in ethanol effects in knock-in mice expressing ethanol insensitive alpha1 and alpha2 glycine receptor subunits., PMID:38679193
Antinociceptive Effects of α2/α3-Subtype-Selective GABAA Receptor Positive Allosteric Modulators KRM-II-81 and NS16085 in Male Rats: Behavioral Specificity., PMID:38670800
Dynamic regulation of CeA gene expression during acute and protracted abstinence from chronic binge drinking of male and female C57BL/6J mice., PMID:38352404
Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes., PMID:38086799
Imbalance of multiple neurotransmitter pathways leading to depression-like behavior and cognitive dysfunction in the triple transgenic mouse model of Alzheimer disease., PMID:37256468
Repurposing ketamine to treat cocaine use disorder: integration of artificial intelligence-based prediction, expert evaluation, clinical corroboration and mechanism of action analyses., PMID:36792381
Characterization of the zebrafish gabra1sa43718/sa43718 germline loss of function allele confirms a function for Gabra1 in motility and nervous system development., PMID:36747751
Alzheimer's disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment., PMID:36636325
Novel variants in GABAA receptor subunits: A possible association with benzodiazepine resistance in patients with drug-resistant epilepsy., PMID:36469977
Gene expression profile for different susceptibilities to sound stimulation: a comparative study on brainstems between two inbred laboratory mouse strains., PMID:36451107
Prospective DNA Methylation Analysis of the CpG GABRA2 Receptor Subunit in Alcohol Dependence during Detoxification., PMID:36422192
Shisa7-Dependent Regulation of GABAA Receptor Single-Channel Gating Kinetics., PMID:36216503
Genetic variations in GABA metabolism and epilepsy., PMID:35850019
Whole-exome sequencing and adrenocorticotropic hormone therapy in individuals with infantile spasms., PMID:35830182
Cellular and molecular signatures of in vivo imaging measures of GABAergic neurotransmission in the human brain., PMID:35440709
Sex differences in GABAA receptor subunit transcript expression are mediated by genotype in subjects with alcohol-related cirrhosis of the liver., PMID:35301805
Human ARHGEF9 intellectual disability syndrome is phenocopied by a mutation that disrupts collybistin binding to the GABAA receptor α2 subunit., PMID:35169261
[Prediction of Q-markers of Citri Reticulatae Pericarpium volatile oil and GC-MS based quantitative analysis]., PMID:34994132
GABAA subunit single nucleotide polymorphisms show sex-specific association to alcohol consumption and mental distress in a Norwegian population-based sample., PMID:34852975
Genomewide Association Analyses of Lactation Persistency and Milk Production Traits in Holstein Cattle Based on Imputed Whole-Genome Sequence Data., PMID:34828436
A quantitative trait variant in Gabra2 underlies increased methamphetamine stimulant sensitivity., PMID:34677900
Positive and Negative Selective Allosteric Modulators of α5 GABAA Receptors: Effects on Emotionality, Motivation, and Motor Function in the 5xFAD Model of Alzheimer's Disease., PMID:34657887
An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population., PMID:34530807
α2-containing γ-aminobutyric acid type A receptors promote stress resiliency in male mice., PMID:34408277
Reductions in midbrain GABAergic and dopamine neuron markers are linked in schizophrenia., PMID:34174930
Gabra2 is a genetic modifier of Dravet syndrome in mice., PMID:34086081
Exploring Potential Biomarkers Underlying the Pathogenesis of Alzheimer's Disease by Bioinformatics Gene Analysis., PMID:33941559
The α3 subunit of GABAA receptors promotes formation of inhibitory synapses in the absence of collybistin., PMID:33901490
Physiological role for GABAA receptor desensitization in the induction of long-term potentiation at inhibitory synapses., PMID:33837214
A standardized polyherbal preparation POL-6 diminishes alcohol withdrawal anxiety by regulating Gabra1, Gabra2, Gabra3, Gabra4, Gabra5 gene expression of GABAA receptor signaling pathway in rats., PMID:33407346
Preserving inhibition with a disinhibitory microcircuit in the retina., PMID:33269700
For research use only. Not for human or drug use.
