Catalog No.
YHE45101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu20-Cys471
Predicted molecular weight
53.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P45452
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MMP-13, MMP13, Matrix metalloproteinase-13, Collagenase 3
Repetitive Compressive Loading Downregulates Mitochondria Function and Upregulates the Cartilage Matrix Degrading Enzyme MMP-13 Through the Coactivation of NAD-Dependent Sirtuin 1 and Runx2 in Osteoarthritic Chondrocytes., PMID:40507779
Chicago Sky Blue 6B modulates MAPK/NF-kB pathway in rat knee osteoarthritis., PMID:40500381
Serum and Urine Biomarkers Can Predict Outcomes after Osteochondral Allograft Transplantation in the Knee., PMID:40499917
Dietary procyanidin B1 attenuates fibrogenesis and inflammation in hepatic fibrosis: research on the possible health benefits of procyanidin B1., PMID:40493038
Hereditary gingival fibromatosis: a case report with a novel SOS1 mutation and systematic review., PMID:40480946
Mineral Content and Extracellular Matrix Protein Expression in Mouse Growth Plates During Epiphyseal Fusion: An Observational Study., PMID:40478277
Unique TMJ-specific transcriptomic signature and its medial layer: Implications in osteoarthritis., PMID:40462979
Effect of intraarticular human umbilical cord mesenchymal stem cells transplantation on cartilage degradation and matrix metalloproteinases in OA rat model., PMID:40450237
Peptide-based smart nanosystem for spatiotemporal regulation of bone immunity and cartilage repair to alleviate osteoarthritis., PMID:40449082
Microneedle Radiofrequency Induces Extracellular Matrix Remodeling Through Fibroblast Activation: A Histological Study in a Porcine Model., PMID:40444432
The impact of aging on achilles tendon ossification in mice., PMID:40437419
Dihydrotestosterone and 17β-estradiol modulate TMJ osteoarthritis development and reveal sex-specific differences in pathogenesis., PMID:40437041
Exosomal miR-574-3p from adipose-derived mesenchymal stem modulates CRIM1/BMPs signaling to restrain chondrocytes hypertrophy and inflammatory response in knee osteoarthritis., PMID:40435818
Mechanosensitive Piezo1 channel is highly expressed in the age-induced fibrotic uterus., PMID:40434609
Chondrocyte fatty acid oxidation drives osteoarthritis via SOX9 degradation and epigenetic regulation., PMID:40425566
Integrative analysis of bulk and single-cell RNA sequencing data reveals increased arachidonic acid metabolism in osteoarthritic chondrocytes., PMID:40417665
ETS1 promotes the expression of Ctsb and Mmp13 during the differentiation of septoclasts from pericytes., PMID:40387924
Sequence and Structure at Play in Designing Allosteric Drugs and Alleviating the Drug Resistance., PMID:40378916
The Age-dependent Influence of the Infrapatellar Fat Pad on Chondrocyte Extracellular Matrix Production., PMID:40375383
Exosomes of Human Fetal Cartilage Progenitor Cells (hFCPCs) Inhibited Interleukin-1β (IL-1β)-Induced Osteoarthritis Phenotype via miR-125b-5p In Vitro., PMID:40372627
ATF1 and miR-27b-3p drive intervertebral disc degeneration through the PPARG/NF-κB signaling axis., PMID:40369110
Naringin Mitigates Chondrocyte Apoptosis in Osteoarthritis by Suppressing the miR-29a-3p-Bax Pathway., PMID:40358971
Chondrogenic and chondroprotective response of composite collagen I/II-hyaluronic acid scaffolds within an inflammatory osteoarthritic environment., PMID:40354044
Pyropia yezoensis Extract Attenuates Osteoarthritis Progression In Vitro and In Vivo., PMID:40352296
[Pharmacodynamics study and establishment of a PK-PD model for Epimedii Folium-Chuanxiong Rhizoma in treating osteoarthritis in rats]., PMID:40350920
Mechanism of action of total saponin Achyranthes in treating knee osteoarthritis explored using network pharmacology and animal experimentation., PMID:40343288
Protein Biomarkers in Venous Leg Ulcer Fluid: A Systematic Review., PMID:40342218
Impact of Escherichia coli and Lipopolysaccharide on the MAPK Signaling Pathway, MMPs, TIMPs, and the uPA System in Bovine Mammary Epithelial Cells., PMID:40332776
Synergistic HDAC4/8 Inhibition Sensitizes Osteosarcoma to Doxorubicin via pAKT/RUNX2 Pathway Modulation., PMID:40332124
Latilactobacillus sakei LB-P12 Ameliorates Osteoarthritis by Reducing Cartilage Degradation and Inflammation via Regulation of NF-κB/HIF-2α Pathway., PMID:40329628
Unveiling the mechanisms of mechanical loading-induced knee osteoarthritis through transcriptomics., PMID:40327988
Obacunone acts as a histone deacetylase 1 inhibitor to limit p38MAPK signaling and alleviate osteoarthritis progression., PMID:40319261
Effect of Plasminogen Activator Inhibitor-1 on extracellular matrix homeostasis in scaffold-free spheroids from human chondrocytes., PMID:40316399
RNA-binding protein HuR interacts with UFM1 mRNA to ameliorate chondrocyte inflammation, apoptosis and extracellular matrix degradation., PMID:40289171
Effects of Oligomeric Proanthocyanidins on Cadmium-Induced Extracellular Matrix Damage via Inhibiting the ERK1/2 Signaling Pathway in Chicken Chondrocytes., PMID:40284819
circ_0002970 promotes fibroblast-like synoviocytes invasion and the inflammatory response through Hippo/YAP signaling to induce CTGF/CCN1 expression in rheumatoid arthritis., PMID:40281642
LGR6 modulates intervertebral disc degeneration through regulation of macrophage efferocytosis., PMID:40281518
FGF18 induces chondrogenesis and anti-osteoarthritic effects in a mouse model for TMJ degeneration., PMID:40273050
Engineered mesenchymal stromal cells with interleukin-1beta sticky-trap attenuate osteoarthritis in knee joints., PMID:40264709
Neferine reduces synovial inflammation and cardiac complications in a collagen-induced arthritis mouse model via inhibiting NF-κB/NLRP3 inflammasome axis., PMID:40262197
Silencing Hmox1 Attenuates Cerebral Ischemia/reperfusion Injury and Inhibits Inflammation and Ferroptosis Via the PPAR-γ/FABP4 Signaling Pathway., PMID:40261607
[Machine learning models established to distinguish OA and RA based on immune factors in the knee joint fluid]., PMID:40260566
Immune response against antibiotic-resistant and antibiotic-sensitive staphylococcus aureus in a rat model of implant infection., PMID:40246912
Unveiling Matrix Metalloproteinase 13's Dynamic Role in Breast Cancer: A Link to Physical Changes and Prognostic Modulation., PMID:40243781
Acupotomy Ameliorates KOA Related Chondrocyte Premature Senescence Through YAP/FOXD1 Pathway., PMID:40241815
Gel@CAT-L hydrogel mediates mitochondrial unfolded protein response to regulate reactive oxygen species and mitochondrial homeostasis in osteoarthritis., PMID:40222260
Synovial Fibroblast Extracellular Vesicles Induce Inflammation via Delivering miR-21-5p in Osteoarthritis., PMID:40214473
Tibetan medicine Wuwei Leze powder improves inflammatory mediated metabolic disorders and bone damage in collagen-induced arthritis rats., PMID:40194641
Early Growth Response 1 Plays an Essential Role in Proinflammatory and Osteoclastogenic Activities of Lipopolysaccharide-Stimulated Osteoblasts., PMID:40193242
Fisetin and resveratrol exhibit senotherapeutic effects and suppress cellular senescence in osteoarthritic cartilage-derived chondrogenic progenitor cells., PMID:40189080
For research use only. Not for human or drug use.
