Catalog No.
YHE25301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr392-Thr566
Predicted molecular weight
22.08 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P40189
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-6 receptor subunit beta, CDw130, IL-6R-beta, Membrane glycoprotein 130, CD130, Oncostatin-M receptor subunit alpha, Interleukin-6 signal transducer, IL-6RB, IL-6R subunit beta, IL6ST, Interleukin-6 receptor subunit beta, gp130
Associations among IL-6 Signaling Molecules in Treg Populations in Patients with Relapsing-Remitting Multiple Sclerosis., PMID:40464469
Hypomethylation of IL6ST promotes development of endometriosis by activating JAK2/STAT3 signaling pathway., PMID:39821173
Inhibitory DNA Aptamer Tools against SOCS3-gp130 Interactions., PMID:39571081
Ironing Out the Mechanism of gp130 Signaling., PMID:39414364
Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer., PMID:39251588
Factors of Interleukin-6 Signaling in COVID-19 Patients with Lung Damage of Varying Degrees: A Pilot Study., PMID:38890212
An Indian Family with Autosomal Dominant Hyper-IgE Syndrome Due to IL6ST Defect., PMID:38578568
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency., PMID:38453915
Whole-Exome Sequencing Reveals the Genomic Profile and IL6ST Variants as a Prognostic Biomarker of Paraneoplastic Pemphigus-Associated Unicentric Castleman Disease., PMID:37839777
New Dominant-Negative IL6ST Variants Expand the Immunological and Clinical Spectrum of GP130-Dependent Hyper-IgE Syndrome., PMID:37273120
Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population., PMID:37243282
miR-223-3p mediates the diabetic kidney disease progression by targeting IL6ST/STAT3 pathway., PMID:36731227
α-Synuclein Induces Neuroinflammation Injury through the IL6ST-AS/STAT3/HIF-1α Axis., PMID:36674945
Variation in IL6ST cytokine family function and the potential of IL6 trans-signalling in ERα positive breast cancer cells., PMID:36565897
CircUBXN7 suppresses cell proliferation and facilitates cell apoptosis in lipopolysaccharide-induced cell injury by sponging miR-622 and regulating the IL6ST/JAK1/STAT3 axis., PMID:36257578
Silibinin eliminates mitochondrial ROS and restores autophagy through IL6ST/JAK2/STAT3 signaling pathway to protect cardiomyocytes from doxorubicin-induced injury., PMID:35839932
CD39 and CD326 Are Bona Fide Markers of Murine and Human Plasma Cells and Identify a Bone Marrow Specific Plasma Cell Subpopulation in Lupus., PMID:35464469
Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells., PMID:35435804
Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55-IL6ST Gene Region in Immature Dendritic Cells., PMID:35111166
A novel aryl-guanidinium derivative, VP79s, targets the signal transducer and activator of transcription 3 signaling pathway, downregulates myeloid cell leukaemia-1 and exhibits preclinical activity against multiple myeloma., PMID:34953891
Diffuse large B-cell lymphoma-derived exosomes push macrophage polarization toward M2 phenotype via GP130/STAT3 signaling pathway., PMID:34922904
Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells., PMID:34803492
New tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatment., PMID:34731090
Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling., PMID:34547509
gp130 Cytokines Activate Novel Signaling Pathways and Alter Bone Dissemination in ER+ Breast Cancer Cells., PMID:34477239
Bazedoxifene, a GP130 Inhibitor, Modulates EMT Signaling and Exhibits Antitumor Effects in HPV-Positive Cervical Cancer., PMID:34445405
Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth., PMID:34380633
5q11.2 deletion syndrome revisited-Further narrowing of the smallest region of overlap for the main clinical characteristics of the syndrome., PMID:34322994
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma., PMID:34087162
Sensing Acute Cellular Rejection in Liver Transplant Patients Using Liver-Derived Extracellular Particles: A Prospective, Observational Study., PMID:34025656
CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity., PMID:33986188
Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses., PMID:33871355
Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome., PMID:33771552
Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection., PMID:33691249
IL-6 as a Mediator of the Association Between Traditional Risk Factors and Future Myocardial Infarction: A Nested Case-Control Study., PMID:33657883
Bioinformatics Analysis Identifies IL6ST as a Potential Tumor Suppressor Gene for Triple-Negative Breast Cancer., PMID:33650093
IL-6 Reduces Mitochondrial Replication, and IL-6 Receptors Reduce Chronic Inflammation in NAFLD and Type 2 Diabetes., PMID:33579000
Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis., PMID:33529758
Mosaic IL6ST variant inducing constitutive GP130 cytokine receptor signaling as a cause of neonatal onset immunodeficiency with autoinflammation and dysmorphy., PMID:33517393
Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells., PMID:33471622
Increased IL-6 and Potential IL-6 trans-signalling in the airways after an allergen challenge., PMID:33471392
Expression of Interleukin 6 signaling receptors in carotid atherosclerosis., PMID:33350884
Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency., PMID:33020483
Alveolar soft-part sarcoma (ASPS) resembles a mesenchymal stromal progenitor: evidence from meta-analysis of transcriptomic data., PMID:32596059
Discovery of bazedoxifene analogues targeting glycoprotein 130., PMID:32388278
Porphyromonas gingivalis Inhibition of MicroRNA-205-5p Expression Modulates Proinflammatory Cytokines in Gingival Epithelial Cells., PMID:32303947
Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome., PMID:32207811
Recurrent chromosomal rearrangements of ROS1, FRK and IL6 activating JAK/STAT pathway in inflammatory hepatocellular adenomas., PMID:31907296
The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3., PMID:31901521
IL-6 trans-signaling drives a STAT3-dependent pathway that leads to structural alterations of the peritoneal membrane., PMID:31841386
For research use only. Not for human or drug use.
