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Recombinant Human CD130/IL6ST Protein, N-His

Catalog #:   YHE25301 Specific References (50) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: P40189
Protein length: Thr392-Thr566
Overview

Catalog No.

YHE25301

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Thr392-Thr566

Predicted molecular weight

22.08 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

P40189

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

IL-6 receptor subunit beta, CDw130, IL-6R-beta, Membrane glycoprotein 130, CD130, Oncostatin-M receptor subunit alpha, Interleukin-6 signal transducer, IL-6RB, IL-6R subunit beta, IL6ST, Interleukin-6 receptor subunit beta, gp130

Data Image
  • SDS-PAGE
    SDS PAGE for recombinant Human CD130/IL6ST protein
References

Associations among IL-6 Signaling Molecules in Treg Populations in Patients with Relapsing-Remitting Multiple Sclerosis., PMID:40464469

Hypomethylation of IL6ST promotes development of endometriosis by activating JAK2/STAT3 signaling pathway., PMID:39821173

Inhibitory DNA Aptamer Tools against SOCS3-gp130 Interactions., PMID:39571081

Ironing Out the Mechanism of gp130 Signaling., PMID:39414364

Defective N-glycosylation of IL6 induces metastasis and tyrosine kinase inhibitor resistance in lung cancer., PMID:39251588

Factors of Interleukin-6 Signaling in COVID-19 Patients with Lung Damage of Varying Degrees: A Pilot Study., PMID:38890212

An Indian Family with Autosomal Dominant Hyper-IgE Syndrome Due to IL6ST Defect., PMID:38578568

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency., PMID:38453915

Whole-Exome Sequencing Reveals the Genomic Profile and IL6ST Variants as a Prognostic Biomarker of Paraneoplastic Pemphigus-Associated Unicentric Castleman Disease., PMID:37839777

New Dominant-Negative IL6ST Variants Expand the Immunological and Clinical Spectrum of GP130-Dependent Hyper-IgE Syndrome., PMID:37273120

Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population., PMID:37243282

miR-223-3p mediates the diabetic kidney disease progression by targeting IL6ST/STAT3 pathway., PMID:36731227

α-Synuclein Induces Neuroinflammation Injury through the IL6ST-AS/STAT3/HIF-1α Axis., PMID:36674945

Variation in IL6ST cytokine family function and the potential of IL6 trans-signalling in ERα positive breast cancer cells., PMID:36565897

CircUBXN7 suppresses cell proliferation and facilitates cell apoptosis in lipopolysaccharide-induced cell injury by sponging miR-622 and regulating the IL6ST/JAK1/STAT3 axis., PMID:36257578

Silibinin eliminates mitochondrial ROS and restores autophagy through IL6ST/JAK2/STAT3 signaling pathway to protect cardiomyocytes from doxorubicin-induced injury., PMID:35839932

CD39 and CD326 Are Bona Fide Markers of Murine and Human Plasma Cells and Identify a Bone Marrow Specific Plasma Cell Subpopulation in Lupus., PMID:35464469

Impaired degradation of YAP1 and IL6ST by chaperone-mediated autophagy promotes proliferation and migration of normal and hepatocellular carcinoma cells., PMID:35435804

Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55-IL6ST Gene Region in Immature Dendritic Cells., PMID:35111166

A novel aryl-guanidinium derivative, VP79s, targets the signal transducer and activator of transcription 3 signaling pathway, downregulates myeloid cell leukaemia-1 and exhibits preclinical activity against multiple myeloma., PMID:34953891

Diffuse large B-cell lymphoma-derived exosomes push macrophage polarization toward M2 phenotype via GP130/STAT3 signaling pathway., PMID:34922904

Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells., PMID:34803492

New tale on LianHuaQingWen: IL6R/IL6/IL6ST complex is a potential target for COVID-19 treatment., PMID:34731090

Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling., PMID:34547509

gp130 Cytokines Activate Novel Signaling Pathways and Alter Bone Dissemination in ER+ Breast Cancer Cells., PMID:34477239

Bazedoxifene, a GP130 Inhibitor, Modulates EMT Signaling and Exhibits Antitumor Effects in HPV-Positive Cervical Cancer., PMID:34445405

Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth., PMID:34380633

5q11.2 deletion syndrome revisited-Further narrowing of the smallest region of overlap for the main clinical characteristics of the syndrome., PMID:34322994

Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma., PMID:34087162

Sensing Acute Cellular Rejection in Liver Transplant Patients Using Liver-Derived Extracellular Particles: A Prospective, Observational Study., PMID:34025656

CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity., PMID:33986188

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses., PMID:33871355

Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome., PMID:33771552

Fluoxetine as an anti-inflammatory therapy in SARS-CoV-2 infection., PMID:33691249

IL-6 as a Mediator of the Association Between Traditional Risk Factors and Future Myocardial Infarction: A Nested Case-Control Study., PMID:33657883

Bioinformatics Analysis Identifies IL6ST as a Potential Tumor Suppressor Gene for Triple-Negative Breast Cancer., PMID:33650093

IL-6 Reduces Mitochondrial Replication, and IL-6 Receptors Reduce Chronic Inflammation in NAFLD and Type 2 Diabetes., PMID:33579000

Down-regulation of GP130 signaling sensitizes bladder cancer to cisplatin by impairing Ku70 DNA repair signaling and promoting apoptosis., PMID:33529758

Mosaic IL6ST variant inducing constitutive GP130 cytokine receptor signaling as a cause of neonatal onset immunodeficiency with autoinflammation and dysmorphy., PMID:33517393

Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells., PMID:33471622

Increased IL-6 and Potential IL-6 trans-signalling in the airways after an allergen challenge., PMID:33471392

Expression of Interleukin 6 signaling receptors in carotid atherosclerosis., PMID:33350884

Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency., PMID:33020483

Alveolar soft-part sarcoma (ASPS) resembles a mesenchymal stromal progenitor: evidence from meta-analysis of transcriptomic data., PMID:32596059

Discovery of bazedoxifene analogues targeting glycoprotein 130., PMID:32388278

Porphyromonas gingivalis Inhibition of MicroRNA-205-5p Expression Modulates Proinflammatory Cytokines in Gingival Epithelial Cells., PMID:32303947

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome., PMID:32207811

Recurrent chromosomal rearrangements of ROS1, FRK and IL6 activating JAK/STAT pathway in inflammatory hepatocellular adenomas., PMID:31907296

The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3., PMID:31901521

IL-6 trans-signaling drives a STAT3-dependent pathway that leads to structural alterations of the peritoneal membrane., PMID:31841386

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human CD130/IL6ST Protein, N-His [YHE25301]
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