Catalog No.
YHE15801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly2-Trp382
Predicted molecular weight
44.63 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P35813
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein phosphatase 2C isoform alpha, PPPM1A, Protein phosphatase 1A, Protein phosphatase IA, PP2C-alpha, PPM1A
Knockdown of TRIM47 Overcomes Paclitaxel Resistance in Ovarian Cancer by Suppressing the TGF-β Pathway via PPM1A., PMID:40435048
Activin A promoted the anti-tumor effect of ActRIIA high CD8+ T cells in mouse hepatoma., PMID:39727149
Nucleostemin interacts with SMAD3 promoting tumor metastasis., PMID:39662660
Tripartite motif 22 interacts with protein phosphatase magnesium-dependent 1 A to aggravate radiation-induced epithelial-mesenchymal transition and fibrogenesis in lung epithelial cells., PMID:39557349
Protein phosphatase PP2Cα S-glutathionylation regulates cell migration., PMID:39303918
Anti-protein phosphatase magnesium-dependent 1A-IgM levels in patients with active ankylosing spondylitis: a potential biomarker., PMID:39272166
Phosphodiesterase 4 is overexpressed in keloid epidermal scars and its inhibition reduces keratinocyte fibrotic alterations., PMID:39223490
Phosphodiesterase 4 is overexpressed in human keloids and its inhibition reduces fibroblast activation and skin fibrosis., PMID:39197814
Otilonium bromide ameliorates pulmonary fibrosis in mice through activating phosphatase PPM1A., PMID:39160244
Study of the Immune Infiltration and Sonic Hedgehog Expression Mechanism in Synovial Tissue of Rheumatoid Arthritis-Related Interstitial Lung Disease under Machine Learning CIBERSORT Algorithm., PMID:39110383
CGMega: explainable graph neural network framework with attention mechanisms for cancer gene module dissection., PMID:39013885
Short-Term Statin Therapy Induces Hepatic Insulin Resistance Through HNF4α/PAQR9/PPM1α Axis Regulated AKT Phosphorylation., PMID:38970167
Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy., PMID:38958057
Role of TRIM59 in regulating PPM1A in the pathogenesis of silicosis and the intervention effect of tanshinone IIA., PMID:38908195
Generation of a PPM1A-deficient human induced pluripotent stem cell line using CRISPR-Cas9 technology., PMID:38643711
Correlation between changes in serum YKL-40, LXRs, PPM1A, and TGF-β1 levels and airway remodeling and lung function in patients with bronchial asthma., PMID:38164946
A Review of Proposed Mechanisms in Rheumatoid Arthritis and Therapeutic Strategies for the Disease., PMID:37861027
NPLC0393 from Gynostemma pentaphyllum ameliorates Alzheimer's disease-like pathology in mice by targeting protein phosphatase magnesium-dependent 1A phosphatase., PMID:37434441
ATF2 orchestrates macrophage differentiation and activation to promote antibacterial responses., PMID:37403209
Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis., PMID:37261432
PPM1A: TGFβ regulator and therapeutic target in OA., PMID:36899081
Extracellular PPM1A promotes mineralization of osteoblasts differentiation in ankylosing spondylitis via the FOXO1A-RUNX2 pathway., PMID:36756789
Protein phosphatase PPM1A inhibition attenuates osteoarthritis via regulating TGF-β/Smad2 signaling in chondrocytes., PMID:36752205
Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis., PMID:36543129
Miltefosine as a PPM1A activator improves AD-like pathology in mice by alleviating tauopathy via microglia/neurons crosstalk., PMID:36388134
Astrocytic NDRG2-PPM1A interaction exacerbates blood-brain barrier disruption after subarachnoid hemorrhage., PMID:36179025
Platyconic acid A‑induced PPM1A upregulation inhibits the proliferation, inflammation and extracellular matrix deposition of TGF‑β1‑induced lung fibroblasts., PMID:36069235
TRIM18 is a critical regulator of viral myocarditis and organ inflammation., PMID:35909127
TRPM7 deficiency exacerbates cardiovascular and renal damage induced by aldosterone-salt., PMID:35882956
Tag you're it: A phosphatase inhibitor changes the fate of intracellular mycobacteria., PMID:35868234
Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding., PMID:35712083
Cross-talk between NOTCH2 and BMP4/SMAD signaling pathways in bovine follicular granulosa cells., PMID:35512514
Knockdown of TRIM65 suppressed the proliferation and invasiveness of gastric cancer cells by restricting the ubiquitin degradation of PPM1A., PMID:35421368
A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis., PMID:35320734
CaM kinase phosphatase (CaMKP/PPM1F/POPX2) is specifically inactivated through gallate-mediated protein carbonylation., PMID:35276214
A six-gene signature related with tumor mutation burden for predicting lymph node metastasis in breast cancer., PMID:35116541
A comprehensive overview of PPM1A: From structure to disease., PMID:34861123
Identification of Differentially Expressed Genes in Different Glioblastoma Regions and Their Association with Cancer Stem Cell Development and Temozolomide Response., PMID:34834399
LncRNA PPM1A-AS Regulate Tumor Development Through Multiple Signal Pathways in T-Cell Acute Lymphoblastic Leukemia., PMID:34746000
Role of active site arginine residues in substrate recognition by PPM1A., PMID:34637963
Complement factor B in high glucose-induced podocyte injury and diabetic kidney disease., PMID:34622800
PPM1A as a key target of the application of Jiawei‑Maxing‑Shigan decoction for the attenuation of radiation‑induced epithelial‑mesenchymal transition in type II alveolar epithelial cells., PMID:34558633
Mechanisms of Systolic Cardiac Dysfunction in PP2A, PP5 and PP2AxPP5 Double Transgenic Mice., PMID:34502355
lncRNA TSPEAR-AS2, a Novel Prognostic Biomarker, Promotes Oral Squamous Cell Carcinoma Progression by Upregulating PPM1A via Sponging miR-487a-3p., PMID:34336002
Fenofibrate inhibits TGF-β-induced myofibroblast differentiation and activation in human lung fibroblasts in vitro., PMID:34228906
CircMAPK9 promotes the progression of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-140-3p/PPM1A axis., PMID:34154607
PP2Acα promotes macrophage accumulation and activation to exacerbate tubular cell death and kidney fibrosis through activating Rap1 and TNFα production., PMID:33934104
MicroRNA-487a-3p inhibits the growth and invasiveness of oral squamous cell carcinoma by targeting PPM1A., PMID:33724144
The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration., PMID:33630828
Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities., PMID:33480423
For research use only. Not for human or drug use.
