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Recombinant Human SRGAP2 Protein, N-His

Catalog #:   YHB06601 Specific References (50) DATASHEET
Applications: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system: E. coli
Accession: O75044
Protein length: Thr494-Phe679
Overview

Catalog No.

YHB06601

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Thr494-Phe679

Predicted molecular weight

23.51 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

O75044

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

KIAA0456, srGAP2, FNBP2, ARHGAP34, SRGAP2, SLIT-ROBO Rho GTPase-activating protein 2, SRGAP2A, Formin-binding protein 2, Rho GTPase-activating protein 34

Data Image
References

Ganoderma lucidum (Curtis) P. Karst. Immunomodulatory Protein Has the Potential to Improve the Prognosis of Breast Cancer Through the Regulation of Key Prognosis-Related Genes., PMID:39770537

Genome-wide association studies of milk composition traits in indicine Badri cattle using ddRAD sequencing approach., PMID:39715884

Rev or restrain: Mechanisms of human-specific synaptic neoteny., PMID:39510039

Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition., PMID:39406239

CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny., PMID:39352808

Deciphering the molecular landscape of the FAM72 gene family: Implications for stem cell biology and cancer., PMID:39236808

Differential Expression of MicroRNA MiR-145 and MiR-155 Downstream Targets in Oral Cancers Exhibiting Limited Chemotherapy Resistance., PMID:38396844

Integrated genetic analysis of diabetic complications: Bioinformatics insights into foot ulcers, neuropathy and peripheral artery disease., PMID:38358067

Urinary exosomes from patients with diabetic kidney disease induced podocyte apoptosis via microRNA-145-5p/Srgap2 and the RhoA/ROCK pathway., PMID:37952894

Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice., PMID:37056152

Genome-Wide Association Screening Determines Peripheral Players in Male Fertility Maintenance., PMID:36613967

Stiff matrix induced srGAP2 tension gradients control migration direction in triple-negative breast cancer., PMID:36593959

Pan-Cancer Analysis Identifies Tumor Cell Surface Targets for CAR-T Cell Therapies and Antibody Drug Conjugates., PMID:36428765

Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2., PMID:36277474

SRGAP2 controls colorectal cancer chemosensitivity via regulation of mitochondrial complex I activity., PMID:36059022

srGAP2 deactivates RhoA to control the duration of thrombin-mediated endothelial permeability., PMID:35441126

C5 and SRGAP3 Polymorphisms Are Linked to Paediatric Allergic Asthma in the Italian Population., PMID:35205259

RapID Cell Counter: Semi-Automated and Mid-Throughput Estimation of Cell Density within Diverse Cortical Layers., PMID:34725102

Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma., PMID:33984363

FAM72, Glioblastoma Multiforme (GBM) and Beyond., PMID:33804473

The cognitive and speech genes are jointly shaped by both positive and relaxed selection in the human lineage., PMID:32387504

Transplantation of sh-miR-199a-5p-Modified Olfactory Ensheathing Cells Promotes the Functional Recovery in Rats with Contusive Spinal Cord Injury., PMID:32252553

Rac1 Inhibition Via Srgap2 Restrains Inflammatory Osteoclastogenesis and Limits the Clastokine, SLIT3., PMID:31880824

The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development., PMID:31822692

Transcriptome Analysis Reveals Novel Genes Associated with Cartilage Degeneration in Posttraumatic Osteoarthritis Progression., PMID:31104480

Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia., PMID:31096545

[Effect of electroacupuncture on muscular atrophy and Slit/Robo signaling in sciatic nerve and lumbar spinal cord tissues in rats with sciatic nerve injury]., PMID:30945485

Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment., PMID:30930167

A Novel Divergent Gene Transcription Paradigm-the Decisive, Brain-Specific, Neural |-Srgap2-Fam72a-| Master Gene Paradigm., PMID:30685845

A cancer tissue-specific FAM72 expression profile defines a novel glioblastoma multiform (GBM) gene-mutation signature., PMID:30414097

A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability., PMID:30048510

In This Issue of Diabetes., PMID:29559509

Dissection of Glomerular Transcriptional Profile in Patients With Diabetic Nephropathy: SRGAP2a Protects Podocyte Structure and Function., PMID:29242313

Mind the (sr)GAP - roles of Slit-Robo GAPs in neurons, brains and beyond., PMID:29097383

The SRGAP2 SNPs, their haplotypes and G × E interactions on serum lipid traits., PMID:28912560

Brain plasticity, cognitive functions and neural stem cells: a pivotal role for the brain-specific neural master gene |-SRGAP2-FAM72-|., PMID:28822221

Mfsd2a (Major Facilitator Superfamily Domain Containing 2a) Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Disruption by Inhibiting Vesicular Transcytosis., PMID:28724654

Structural History of Human SRGAP2 Proteins., PMID:28333212

Cognitive Functions: Human vs. Animal - 4:1 Advantage |-FAM72-SRGAP2-|., PMID:28255958

Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma., PMID:27966608

Molecular symmetry-constrained systematic search approach to structure solution of the coiled-coil SRGAP2 F-BARx domain., PMID:27917825

Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice., PMID:27889896

Dynamic expression of srGAP2 in cell nuclei and cytoplasm during the differentiation of rat neural stem cells in vitro., PMID:27748913

Filling the (SR)GAP in Excitatory/Inhibitory Balance., PMID:27477010

SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses., PMID:27373832

A combinative analysis of gene expression profiles and microRNA expression profiles identifies critical genes and microRNAs in oral lichen planus., PMID:27100321

The role of heparan sulfate deficiency in autistic phenotype: potential involvement of Slit/Robo/srGAPs-mediated dendritic spine formation., PMID:27089953

Human umbilical cord blood mononuclear cells and chorionic plate-derived mesenchymal stem cells promote axon survival in a rat model of optic nerve crush injury., PMID:26986762

Evolution of the SRGAP2 Gene Is Linked to Intelligence in Mammals., PMID:31988884

SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion., PMID:26439400

Datasheet
$ 330
Product specifications
100 μg 330 1 mg 1880

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For research use only. Not for human or drug use.

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Recombinant Human SRGAP2 Protein, N-His [YHB06601]
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