Catalog No.
YHB06601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr494-Phe679
Predicted molecular weight
23.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75044
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA0456, srGAP2, FNBP2, ARHGAP34, SRGAP2, SLIT-ROBO Rho GTPase-activating protein 2, SRGAP2A, Formin-binding protein 2, Rho GTPase-activating protein 34
Ganoderma lucidum (Curtis) P. Karst. Immunomodulatory Protein Has the Potential to Improve the Prognosis of Breast Cancer Through the Regulation of Key Prognosis-Related Genes., PMID:39770537
Genome-wide association studies of milk composition traits in indicine Badri cattle using ddRAD sequencing approach., PMID:39715884
Rev or restrain: Mechanisms of human-specific synaptic neoteny., PMID:39510039
Synaptic neoteny of human cortical neurons requires species-specific balancing of SRGAP2-SYNGAP1 cross-inhibition., PMID:39406239
CTNND2 moderates the pace of synaptic maturation and links human evolution to synaptic neoteny., PMID:39352808
Deciphering the molecular landscape of the FAM72 gene family: Implications for stem cell biology and cancer., PMID:39236808
Differential Expression of MicroRNA MiR-145 and MiR-155 Downstream Targets in Oral Cancers Exhibiting Limited Chemotherapy Resistance., PMID:38396844
Integrated genetic analysis of diabetic complications: Bioinformatics insights into foot ulcers, neuropathy and peripheral artery disease., PMID:38358067
Urinary exosomes from patients with diabetic kidney disease induced podocyte apoptosis via microRNA-145-5p/Srgap2 and the RhoA/ROCK pathway., PMID:37952894
Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice., PMID:37056152
Genome-Wide Association Screening Determines Peripheral Players in Male Fertility Maintenance., PMID:36613967
Stiff matrix induced srGAP2 tension gradients control migration direction in triple-negative breast cancer., PMID:36593959
Pan-Cancer Analysis Identifies Tumor Cell Surface Targets for CAR-T Cell Therapies and Antibody Drug Conjugates., PMID:36428765
Tumor-Derived Exosomal miR-29b Reduces Angiogenesis in Pancreatic Cancer by Silencing ROBO1 and SRGAP2., PMID:36277474
SRGAP2 controls colorectal cancer chemosensitivity via regulation of mitochondrial complex I activity., PMID:36059022
srGAP2 deactivates RhoA to control the duration of thrombin-mediated endothelial permeability., PMID:35441126
C5 and SRGAP3 Polymorphisms Are Linked to Paediatric Allergic Asthma in the Italian Population., PMID:35205259
RapID Cell Counter: Semi-Automated and Mid-Throughput Estimation of Cell Density within Diverse Cortical Layers., PMID:34725102
Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma., PMID:33984363
FAM72, Glioblastoma Multiforme (GBM) and Beyond., PMID:33804473
The cognitive and speech genes are jointly shaped by both positive and relaxed selection in the human lineage., PMID:32387504
Transplantation of sh-miR-199a-5p-Modified Olfactory Ensheathing Cells Promotes the Functional Recovery in Rats with Contusive Spinal Cord Injury., PMID:32252553
Rac1 Inhibition Via Srgap2 Restrains Inflammatory Osteoclastogenesis and Limits the Clastokine, SLIT3., PMID:31880824
The human-specific paralogs SRGAP2B and SRGAP2C differentially modulate SRGAP2A-dependent synaptic development., PMID:31822692
Transcriptome Analysis Reveals Novel Genes Associated with Cartilage Degeneration in Posttraumatic Osteoarthritis Progression., PMID:31104480
Identification and Characterization of Novel Fusion Genes with Potential Clinical Applications in Mexican Children with Acute Lymphoblastic Leukemia., PMID:31096545
[Effect of electroacupuncture on muscular atrophy and Slit/Robo signaling in sciatic nerve and lumbar spinal cord tissues in rats with sciatic nerve injury]., PMID:30945485
Leukocyte Cytoskeleton Polarization Is Initiated by Plasma Membrane Curvature from Cell Attachment., PMID:30930167
A Novel Divergent Gene Transcription Paradigm-the Decisive, Brain-Specific, Neural |-Srgap2-Fam72a-| Master Gene Paradigm., PMID:30685845
A cancer tissue-specific FAM72 expression profile defines a novel glioblastoma multiform (GBM) gene-mutation signature., PMID:30414097
A functional siRNA screen identifies RhoGTPase-associated genes involved in thrombin-induced endothelial permeability., PMID:30048510
In This Issue of Diabetes., PMID:29559509
Dissection of Glomerular Transcriptional Profile in Patients With Diabetic Nephropathy: SRGAP2a Protects Podocyte Structure and Function., PMID:29242313
Mind the (sr)GAP - roles of Slit-Robo GAPs in neurons, brains and beyond., PMID:29097383
The SRGAP2 SNPs, their haplotypes and G × E interactions on serum lipid traits., PMID:28912560
Brain plasticity, cognitive functions and neural stem cells: a pivotal role for the brain-specific neural master gene |-SRGAP2-FAM72-|., PMID:28822221
Mfsd2a (Major Facilitator Superfamily Domain Containing 2a) Attenuates Intracerebral Hemorrhage-Induced Blood-Brain Barrier Disruption by Inhibiting Vesicular Transcytosis., PMID:28724654
Structural History of Human SRGAP2 Proteins., PMID:28333212
Cognitive Functions: Human vs. Animal - 4:1 Advantage |-FAM72-SRGAP2-|., PMID:28255958
Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma., PMID:27966608
Molecular symmetry-constrained systematic search approach to structure solution of the coiled-coil SRGAP2 F-BARx domain., PMID:27917825
Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice., PMID:27889896
Dynamic expression of srGAP2 in cell nuclei and cytoplasm during the differentiation of rat neural stem cells in vitro., PMID:27748913
Filling the (SR)GAP in Excitatory/Inhibitory Balance., PMID:27477010
SRGAP2 and Its Human-Specific Paralog Co-Regulate the Development of Excitatory and Inhibitory Synapses., PMID:27373832
A combinative analysis of gene expression profiles and microRNA expression profiles identifies critical genes and microRNAs in oral lichen planus., PMID:27100321
The role of heparan sulfate deficiency in autistic phenotype: potential involvement of Slit/Robo/srGAPs-mediated dendritic spine formation., PMID:27089953
Human umbilical cord blood mononuclear cells and chorionic plate-derived mesenchymal stem cells promote axon survival in a rat model of optic nerve crush injury., PMID:26986762
Evolution of the SRGAP2 Gene Is Linked to Intelligence in Mammals., PMID:31988884
SrGAP2-Dependent Integration of Membrane Geometry and Slit-Robo-Repulsive Cues Regulates Fibroblast Contact Inhibition of Locomotion., PMID:26439400
For research use only. Not for human or drug use.
