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Anti-Desmoglein 3 Antibody (AK23)

Catalog #:   RHE01406 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG1, kappa
Applications: ELISA, IF, IP
Accession: P32926
Overview

Catalog No.

RHE01406

Species reactivity

Human, Mouse

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

Cadherin family member 6, DSG3, Desmoglein-3, 130 kDa pemphigus vulgaris antigen, PVA, CDHF6

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P32926

Applications

ELISA, IF, IP

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

AK23

Data Image
References

Desmoglein-3 autoantibodies in tissues of oral lichen planus patients and its correlation with disease severity: case-control study., PMID:40481453

Epac1 contributes to apremilast-mediated rescue of pemphigus autoantibody-induced loss of keratinocyte adhesion., PMID:40299565

Epitomic profiling and functional characteristics of pemphigus vulgaris autoantibody binding to keratinocyte M3 muscarinic acetylcholine receptor., PMID:40120680

Clinical Features, Diagnosis and Treatment of Different Types of Paediatric Pemphigus., PMID:40059466

Prevalence and pathogenic activity of anti-desmocollin-3 antibodies in patients with pemphigus vulgaris and pemphigus foliaceus., PMID:39989391

Diagnostic methods and strategies for autoimmune bullous diseases., PMID:39930606

Optimizing Pemphigus Management With Rituximab and Short-Term Relapse Predictors., PMID:39908046

The impact of signaling pathways on the desmosome ultrastructure in pemphigus., PMID:39882246

Case report: A rollercoaster journey of pemphigus vegetans., PMID:39872528

Augmented IFNγ producing ILC1 and IL 17 producing ILC3 in pemphigus vulgaris: Plausible therapeutic target., PMID:39718308

Use of multivariant enzyme-linked immunosorbent assay (ELISA) in the diagnosis of autoimmune bullous disorders in a resource-limited setting: A single-center experience., PMID:39635793

Pemphigus relapse: Mechanisms, risk factors, and agents associated with disease recurrence., PMID:39460496

Quality-controlled characterization of a monoclonal antibody specific to an EC5-domain of human desmoglein 3 for pemphigus research., PMID:39450179

Binding to the neonatal Fc receptor enhances the pathogenicity of anti-desmoglein-3 antibodies in keratinocytes., PMID:39450168

IgG reactivity to different desmoglein-3 ectodomains in pemphigus vulgaris: novel panels for assessing disease severity., PMID:39416775

Data-Driven Image Analysis to Determine Antibody-Induced Dissociation of Cell-Cell Adhesion and Antibody Pathogenicity in Pemphigus Vulgaris., PMID:39416220

Human dental mesenchymal stem cells restorate immune response in sera of pemphigus vulgaris patients., PMID:39352524

Unbiased screening identifies regulators of cell-cell adhesion and treatment options in pemphigus., PMID:39271654

Comparison of serum cytokines and chemokines levels and clinical significance in patients with pemphigus vulgaris-A retrospective study., PMID:39246287

shRNA-Targeting Caspase-3 Inhibits Cell Detachment Induced by Pemphigus Vulgaris Autoantibodies in HaCaT Cells., PMID:39201550

Standardized Production of Anti-Desmoglein 3 Antibody AK23 for Translational Pemphigus Vulgaris Research., PMID:39169810

Pathogenic relevance of antibodies against desmoglein 3 in patients with oral lichen planus., PMID:39152677

Co-occurrence of oral pemphigus vulgaris and herpes simplex virus infection in a young patient with Crohn's disease: report of a rare case of oral lesions during anti-TFN alpha and immunomodulator therapy., PMID:39105861

Direct immunofluorescence on plucked hair outer root sheath can predict relapse in pemphigus vulgaris., PMID:39086016

Alteration of reactive oxygen species master transcription factor Nrf2 in keratinocytes exposed to monoclonal pathogenic antibody AK23 against desmoglein-3 in pemphigus vulgaris., PMID:39037929

Immunostimulatory effects of Toll-like receptor ligands as adjuvants in establishing a novel mouse model for pemphigus vulgaris., PMID:39031979

A Case Report on Senear-Usher Syndrome., PMID:38957191

Multiplex Intraoperative Rapid Immunohistochemistry with Noncontact Antibody Mixing for Distinguishing the Histologic Phenotype of Lung Cancer., PMID:38934168

State-of-the-art diagnosis of autoimmune blistering diseases., PMID:38903493

Factors associated with non-pathogenic antibodies against desmoglein-3 in pemphigus foliaceus., PMID:38851894

The emergence of circulating activated autoreactive desmoglein 3-specific follicular regulatory T cells is associated with long-term efficacy of rituximab in patients with pemphigus vulgaris., PMID:38848544

Desmosomal Cadherin Tension Loss in Pemphigus Vulgaris Mediated by the Inhibition of Active RhoA at Cell-Cell Adhesions., PMID:38766211

A case of bullous pemphigoid complicated by mucosal lesions due to mucosal-dominant pemphigus vulgaris: analyzing the pathogenicity of anti-desmoglein 3 antibodies using a bead aggregation assay., PMID:38741281

Desmosomal Hyper-Adhesion Affects Direct Inhibition of Desmoglein Interactions in Pemphigus., PMID:38677661

EGFR Inhibition by Erlotinib Rescues Desmosome Ultrastructure and Keratin Anchorage and Protects against Pemphigus Vulgaris IgG-Induced Acantholysis in Human Epidermis., PMID:38642796

Maintenance treatment of pemphigus with rituximab in real life: A single-center study of 50 patients., PMID:38537431

Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatment., PMID:38504438

Differences among Indian and European pemphigus patients based on demographics, clinical parameters and propensity for relapse: results of a prospective bicontinental cohort study., PMID:38465545

The Need of Differential Diagnosis Between Vulvar Lichen Sclerosus and Autoimmune Dermatoses in Adolescent Girls., PMID:38451422

SARS-CoV-2 Infection in Pemphigus Vulgaris Two Weeks after Rituximab Therapy with Total Recovery: A Case Report., PMID:38439728

Rituximab in the Management of Autoimmune Bullous Diseases: A Treatment-Resistant Case Series from a Single Central European Referral Center., PMID:38399557

Desmoglein autoantibodies and disease severity in pemphigus patients - correlations and discrepancies., PMID:38351787

Novel nanoparticle AuNCs conjugated with Desmoglein-3 antibody for FL/CT dual-mode targeted imaging and precise treatment of lung squamous cell carcinoma., PMID:38224630

Pemphigus vulgaris relapsed with serological shift from single-positive desmoglein-3 antibodies to single-positive desmoglein-1 antibodies., PMID:38212901

Comparison of gut microbiota dysbiosis between pemphigus vulgaris and bullous pemphigoid., PMID:38185033

A case of paraneoplastic pemphigus associated with follicular lymphoma positive only for anti-desmoglein 3 antibody., PMID:38111329

Tacrolimus reverses pemphigus vulgaris serum-induced depletion of desmoglein in HaCaT cells via inhibition of heat shock protein 27 phosphorylation., PMID:37940861

Integrative single-cell analysis reveals distinct adaptive immune signatures in the cutaneous lesions of pemphigus., PMID:37939532

Microenvironmental network of clonal CXCL13+CD4+ T cells and Tregs in pemphigus chronic blisters., PMID:37815865

Detection of herpes simplex viruses in the oral lesions of patients with pemphigus vulgaris: Is it diagnostic or predictive of disease severity?, PMID:37799351

Datasheet
$ 372
Product specifications
100 μg 372 1 mg 1860

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Anti-Desmoglein 3 Antibody (AK23) [RHE01406]
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