Catalog No.
YHB34902
Expression system
E. coli
Species
Human
Protein length
[Glu2-Phe120] & [Gly253-Arg293] & [Leu370-Arg417]
Predicted molecular weight
40.40 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75908
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 5% Trehalose, 2% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ACAT2, Cholesterol acyltransferase 2, Acyl-coenzyme A:cholesterol acyltransferase 2, SOAT2, ACAT-2, ACACT2, Sterol O-acyltransferase 2
The impact of de novo lipogenesis on predicting survival and clinical therapy: an exploration based on a multigene prognostic model in hepatocellular carcinoma., PMID:40533802
Transcriptomic and metabonomic profiling unveils the mechanism of Tartary buckwheat and kiwi co-fermentation products in hyperlipidemia treatment., PMID:40520184
Identification of circulating tumor cells marker genes as prognostic signature in triple-negative breast cancer., PMID:40413298
Father's adolescent body silhouette is associated with offspring asthma, lung function and BMI through DNA methylation., PMID:40410506
Association of Increased SOAT2 Expression with Abnormal Cholesterol Esterification and Testosterone Deficiency in Late-Onset Hypogonadism Rats., PMID:40396327
Novel molecular mechanisms of immune evasion in hepatocellular carcinoma: NSUN2-mediated increase of SOAT2 RNA methylation., PMID:40227950
Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking., PMID:39884015
Dietary Tannic Acid Promotes Growth Performance and Resistance Against Aeromonas hydrophila Infection by Improving the Antioxidative Capacity and Intestinal Health in the Chinese Soft-Shelled Turtle (Pelodiscus sinensis)., PMID:39857447
Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity., PMID:39805872
ELAVL1-dependent SOAT2 exacerbated the pancreatitis-like cellular injury of AR42J cells induced by hyperstimulation with caerulein., PMID:39588852
Fatty acid metabolism prognostic signature predicts tumor immune microenvironment and immunotherapy, and identifies tumorigenic role of MOGAT2 in lung adenocarcinoma., PMID:39478862
Drimane sesquiterpene esters produced by Aspergillus insuetus BF-1613 as inhibitors of sterol O-acyltransferase., PMID:39385005
siRNA/CS-PLGA Nanoparticle System Targeting Knockdown Intestinal SOAT2 Reduced Intestinal Lipid Uptake and Alleviated Obesity., PMID:39297413
Investigating the potential mechanism and therapeutic effects of SLXG for cholesterol gallstone treatment., PMID:39059092
Comprehensive prognostic and immune analysis of sterol O-acyltransferase 1 in patients with hepatocellular carcinoma., PMID:38577529
Soat2 inhibitor avasimibe alleviates acute pancreatitis by suppressing acinar cell ferroptosis., PMID:38376541
Insights into sequence characteristics and evolutionary history of DGATs in arthropods., PMID:38266530
ACAT2 may be a novel predictive biomarker and therapeutic target in lung adenocarcinoma., PMID:38213102
Placental extract suppresses lipid droplet accumulation by autophagy during the differentiation of adipose-derived mesenchymal stromal/stem cells into mature adipocytes., PMID:37974253
Pigment Identification and Gene Expression Analysis during Erythrophore Development in Spotted Scat (Scatophagus argus) Larvae., PMID:37895036
DNA Methylation of Genes Participating in Hepatic Metabolisms and Function in Fetal Calf Liver Is Altered by Maternal Undernutrition during Gestation., PMID:37445858
The Immune Landscape and Molecular Subtypes of Pediatric Crohn's Disease: Results from In Silico Analysis., PMID:37108957
Comparative Analysis of miRNA-mRNA Regulation in the Testes of Gobiocypris rarus following 17α-Methyltestosterone Exposure., PMID:36835651
Identification of the prognostic value of Th1/Th2 ratio and a novel prognostic signature in basal-like breast cancer., PMID:36694223
Targeting Sterol O-Acyltransferase/Acyl-CoA:Cholesterol Acyltransferase (ACAT): A Perspective on Small-Molecule Inhibitors and Their Therapeutic Potential., PMID:36473091
Plasma FA composition in familial LCAT deficiency indicates SOAT2-derived cholesteryl ester formation in humans., PMID:35598637
Antihyperlipidemic Activity of Gut-Restricted LXR Inverse Agonists., PMID:35417135
HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of HNF4A Promoter Activity with Possible Disruption in Transcription Networks., PMID:35327967
ACAT2 as a novel therapeutic target to treat fatty liver disease., PMID:35143097
Soat2 ties cholesterol metabolism to β-oxidation and glucose tolerance in male mice., PMID:34982494
Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT) in Cholesterol Metabolism: From Its Discovery to Clinical Trials and the Genomics Era., PMID:34436484
High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer., PMID:34326474
Sterol O-acyltransferase 2 chaperoned by apolipoprotein J facilitates hepatic lipid accumulation following viral and nutrient stresses., PMID:33980978
Combined Lipidomics and Network Pharmacology Study of Protective Effects of Salvia miltiorrhiza against Blood Stasis Syndrome., PMID:33790973
A Combination of Single Nucleotide Polymorphisms is Associated with the Interindividual Variability of Cholesterol Bioavailability in Healthy Adult Males., PMID:32996248
Gene expression in rat placenta after exposure to di(2-ethylhexyl) phthalate., PMID:32909833
Delineation of metabolic responses of Npc1-/-nih mice lacking the cholesterol-esterifying enzyme SOAT2 to acute treatment with 2-hydroxypropyl-β-cyclodextrin., PMID:32890578
Whole-exome sequencing and genome-wide association studies identify novel sarcopenia risk genes in Han Chinese., PMID:32478482
The Anti-atherogenic Activity of Beauveriolide Derivative BVD327, a Sterol O-Acyltransferase 2-Selective Inhibitor, in Apolipoprotein E Knockout Mice., PMID:32475917
Voluhemins, new inhibitors of sterol O-acyltransferase, produced by Volutella citrinella BF-0440., PMID:32467602
Generation of new hepatocyte-like in vitro models better resembling human lipid metabolism., PMID:32058035
Enhanced acyl-CoA:cholesterol acyltransferase activity increases cholesterol levels on the lipid droplet surface and impairs adipocyte function., PMID:31727739
Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis., PMID:31681760
Influence of dietary linseed oil as substitution of fish oil on whole fish fatty acid composition, lipid metabolism and oxidative status of juvenile Manchurian trout, Brachymystax lenok., PMID:31554849
Ontogenesis and Modulation of Intestinal Unesterified Cholesterol Sequestration in a Mouse Model of Niemann-Pick C1 Disease., PMID:31312996
Genetic depletion of Soat2 diminishes hepatic steatosis via genes regulating de novo lipogenesis and by GLUT2 protein in female mice., PMID:30630736
Helvamide, a new inhibitor of sterol O-acyltransferase produced by the fungus Aspergillus nidulans BF-0142., PMID:30305686
Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307., PMID:30177721
Overexpression of transforming growth factor β induced factor homeobox 1 represses NPC1L1 and lowers markers of intestinal cholesterol absorption., PMID:29980051
Quantifying and Localizing the Mitochondrial Proteome Across Five Tissues in A Mouse Population., PMID:29945935
For research use only. Not for human or drug use.
