Anti-NOTCH2 Antibody (SAb2264)

Catalog No.

RHG01804

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

ELISA: 1:5000-1:20000, IF: 1:200-1:1000, IHC: 1:100-1:1000, WB: 1:1000-1:5000, IP: 1:50-1:200

Target

N2ICD, N2ECD, NOTCH2, hN2, Neurogenic locus notch homolog protein 2, Notch 2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Applications

ELISA, IF, WB, IHC, IP

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 0.05% Proclin 300, 50% Glycerol.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

SAb2264

Treatment outcomes of BTK inhibitors and venetoclax with or without anti-CD20 monoclonal antibody in relapsed or refractory mantle cell lymphoma., PMID:40278919

Case report: Near-complete response to neratinib-based treatment in HR-positive HER2-amplified metastatic breast cancer refractory to trastuzumab deruxtecan., PMID:39931207

Combined Molecular Subclass and Immune Phenotype Correlate to Atezolizumab Plus Radiation Therapy Response in Invasive Bladder Cancer: BPT-ART Phase 2 Study., PMID:39755215

TP53 Mutation Is the Only Robust Mutational Biomarker for Outcome Found in a Consecutive Clinical Cohort of Real-Word Patients With Primary Large B-Cell Lymphoma., PMID:39691999

Truncated recombinant Jagged1 fused with human IgG1 Fc activates Notch target genes in human periodontal ligament cells., PMID:39643955

Modulation of Notch signaling pathway in activated hepatic stellate cells does not ameliorate the outcome of liver fibrosis in carbon tetrachloride and DDC-feeding models., PMID:39529885

Familial adult-onset neuronal intranuclear inclusion disease: A case report and literature review., PMID:39496005

Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy efficacy in melanoma by promoting an inflamed TME., PMID:39491031

The Marginal Zone B Cell Compartment and T Cell-independent Antibody Responses Are Supported by B Cell Intrinsic Expression of IRF1., PMID:39451043

Application of Monoclonal Antibodies against Naturally Occurring Bioactive Ingredients., PMID:39189231

Notch2 signaling governs activated B cells to form memory B cells., PMID:38990721

Disulfide-constrained peptide scaffolds enable a robust peptide-therapeutic discovery platform., PMID:38547109

Notch2 controls developmental fate choices between germinal center and marginal zone B cells upon immunization., PMID:38438375

Notch-1/2 receptors and Jagged-1 ligand, but not HERP-1 transcription factor, are immunohistochemically expressed in the epithelial lining of periapical cysts., PMID:38314334

Chronic Lymphocytic Leukemia IGHV Somatic Hypermutation Detection by Targeted Capture Next-Generation Sequencing., PMID:38175592

NOTCH2 sensitizes the chondrocyte to the inflammatory response of tumor necrosis factor α., PMID:37865314

Heimdall, an alternative protein issued from a ncRNA related to kappa light chain variable region of immunoglobulins from astrocytes: a new player in neural proteome., PMID:37587118

Trastuzumab-induced human cardiomyocyte damage through the Notch2/JAK2/STAT3 pathway., PMID:37567042

Genomics of ERBB2-Positive Breast Cancer in Young Women Before and After Exposure to Chemotherapy Plus Trastuzumab., PMID:37364233

DLBCL-associated NOTCH2 mutations escape ubiquitin-dependent degradation and promote chemoresistance., PMID:37235754

Overexpression and potential roles of midkine via regulation of vascular endothelial growth factor A in psoriasis., PMID:37218430

Clinical, radiological, and molecular analyses of neuronal intranuclear inclusion disease with polyglycine inclusions., PMID:37001413

Waldenström Macroglobulinemia and Non-IgM-Type Lymphoplasmacytic Lymphoma Are Genetically Similar., PMID:36917966

CK2β-regulated signaling controls B cell differentiation and function., PMID:36713383

Role of Notch2 pathway in mature B cell malignancies., PMID:36686759

Exploratory use of romosozumab for osteoporosis in a patient with Hajdu-Cheney syndrome: a case report., PMID:36622389

Notch2-dependent GATA3+ Treg cells alleviate allergic rhinitis by suppressing the Th2 cell response., PMID:36155282

Notch Signaling Promotes Mature T-Cell Lymphomagenesis., PMID:36006995

Therapeutic Targeting Notch2 Protects Bone Micro-Vasculatures from Methotrexate Chemotherapy-Induced Adverse Effects in Rats., PMID:35954226

Extra arginine supplementation during the suckling period alleviates weaning stress through the regulation of dendritic cells and Notch2 signaling in piglets., PMID:35899814

FcγRIIB regulates autoantibody responses by limiting marginal zone B cell activation., PMID:35819855

Iristectorigenin A exerts novel protective properties against airway inflammation and mucus hypersecretion in OVA-induced asthmatic mice: Iristectorigenin A ameliorates asthma phenotype., PMID:35752075

Pancreatic-Like Cells Derived From Mouse Embryonic Stem Cells Are Regulated by Pdx1 Involving the Notch Pathway., PMID:35695761

Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells., PMID:35579963

Notch2 Blockade Mitigates Methotrexate Chemotherapy-Induced Bone Loss and Marrow Adiposity., PMID:35563828

Methotrexate treatment suppresses osteoblastic differentiation by inducing Notch2 signaling and blockade of Notch2 rescues osteogenesis by preserving Wnt/β-catenin signaling., PMID:34935186

Revised International Prognostic Index and genetic alterations are associated with early failure to R-CHOP in patients with diffuse large B-cell lymphoma., PMID:34632572

Oral Surgery Procedures in a Patient with Hajdu-Cheney Syndrome Treated with Denosumab-A Rare Case Report., PMID:34501688

Cooperation Between Cancer and Fibroblasts in Vascular Mimicry and N2-Type Neutrophil Recruitment via Notch2-Jagged1 Interaction in Lung Cancer., PMID:34485133

Resting innate-like B cells leverage sustained Notch2/mTORC1 signaling to achieve rapid and mitosis-independent plasma cell differentiation., PMID:34473651

Delta-like 1-Expressing Cells at the Gland Base Promote Proliferation of Gastric Antral Stem Cells in Mouse., PMID:34438113

Risk-tailored treatment of splenic marginal zone lymphoma., PMID:34407041

Protein Kinase CK2 Regulates B Cell Development and Differentiation., PMID:34301844

Profiling of 520 Candidate Genes in 50 Surgically Treated Chinese Small Cell Lung Cancer Patients., PMID:34168983

A Homozygous Dab1-/- Is a Potential Novel Cause of Autosomal Recessive Congenital Anomalies of the Mice Kidney and Urinary Tract., PMID:33924028

Adult-onset neuronal intranuclear inclusion disease, with both stroke-like onset and encephalitic attacks: a case report., PMID:33789591

Early Covert Appearance of Marginal Zone B Cells in Salivary Glands of Sjögren's Syndrome-Susceptible Mice: Initiators of Subsequent Overt Clinical Disease., PMID:33671965

BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation., PMID:33534893

High expression of Notch2 drives tongue squamous cell carcinoma carcinogenesis., PMID:33382997

O-Fucose and Fringe-modified NOTCH1 extracellular domain fragments as decoys to release niche-lodged hematopoietic progenitor cells., PMID:33351914

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