Catalog No.
YHK09201
Expression system
E. coli
Species
Human
Protein length
[Met1-Lys43] & [Val117-Glu130] & [Met211-Arg234] & [Ala287-Leu317]
Predicted molecular weight
14.80 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UPY5
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Amino acid transport system xc-, SLC7A11, Cystine/glutamate transporter, Calcium channel blocker resistance protein CCBR1, Solute carrier family 7 member 11, xCT
Pomolic acid induces ferroptosis-mediated cell death in non-small cell lung cancer., PMID:40535769
SLC7A11-mediated cell death mechanism in cancer: a comparative study of disulfidptosis and ferroptosis., PMID:40535572
Ghrelin alleviates high glucose-induced retinal microvascular endothelial cell injury by activating Nrf2/HO-1 pathway to inhibit ferroptosis., PMID:40534808
Dimethylmalonate induces ferroptosis by inhibiting the SUCNR1/PI3K/HIF-1α/SLC7A11 signaling axis in triple-negative breast cancer., PMID:40532859
Qing-Re-Xiao-Zheng-(Yi-Qi) formula attenuates the renal podocyte ferroptosis in diabetic kidney disease through AMPK pathway., PMID:40532799
IGF2BP3 enhances ferroptosis resistance in colon cancer by stabilizing SLC7A11 and is regulated by miR-98-5p., PMID:40530014
Catechin inhibits ox-LDL-induced ferroptosis in vascular smooth muscle cells to alleviate and stabilize atherosclerosis., PMID:40529424
Pharmacological Activation of GPR68 Attenuates Ferroptosis in Spinal Cord Ischemia/Reperfusion Injury Through PI3K/Akt-Mediated Nrf2 Antioxidant Pathway., PMID:40528120
Microwave exposure induced ferroptosis by inhibiting the Nrf2 pathway and affected reproductive function in male mice., PMID:40527021
Huangqin decoction alleviates chemotherapy-induced intestinal injury by inhibiting ferroptosis via modulation of P53/SLC7A11/GPX4 pathway., PMID:40513923
C1q/TNF-related protein-9 promotes diabetic wound healing by enhancing dendritic cell efferocytosis via the ATF3/SLC7A11 signaling axis., PMID:40513334
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate Syndrome-Linked p63 Mutations Disrupt Keratinocyte Proliferation and Survival Through Oxidative Stress and Impaired Slc7a11 Expression., PMID:40508040
Inhibition of Ferroptosis Attenuates Neuron Damage and Improves Cognitive Impairment in Mice Surviving Severe Hypothermia., PMID:40507777
The role of HSPB1 in modulating ferroptosis in pancreatic cancer via the TP53/SLC7A11/GPX4 axis., PMID:40504332
Mechanistic Insights Into hsa_circ_0005654-Induced Ferroptosis in Diabetic Foot Ulcers Through IGF2BP2 Interaction., PMID:40504123
Dietary supplementation of Lactobacillus casei alleviates permethrin exposure-induced zebrafish testis damage through modulation of TLR4/NF-κB and AKT/Nrf2 pathways: Oxidative stress, inflammation and ferroptosis., PMID:40500058
Distinct Types of Regulated Cell Death in Melanoma., PMID:40497999
Inhibitors of p53 Apoptosis-Stimulating Protein Mitigate Acute Kidney Injury by Modulating the HIF-1α/SLC7A11 Pathway to Suppress Ferroptosis., PMID:40492946
EBBP-Mediated Integrated Stress Response Attenuates Anthracycline-Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes., PMID:40491313
Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition., PMID:40490825
Picroside II regulates the YY1/TGFβ1 axis by inhibiting osteoblast ferroptosis to alleviate symptoms of postmenopausal osteoporosis., PMID:40488210
Simvastatin inhibits proliferation and migration, promotes oxidative stress and ferroptosis in colon cancer., PMID:40487942
Acteoside ameliorates hepatocyte ferroptosis and hepatic ischemia-reperfusion injury via targeting PCBP2., PMID:40486855
p52-ZER6/DAZAP1 axis promotes ferroptosis resistance and colorectal cancer progression via regulating SLC7A11 mRNA stabilization., PMID:40486833
Downregulation of Alox5 Inhibits Ferroptosis to Improve Doxorubicin-Induced Cardiotoxicity via the P53/SLC7A11 Pathway., PMID:40485049
Dynamic regulators of ferroptosis: Post-translational modifications in ferroptotic cell death., PMID:40482689
NOC2L inhibits trophoblast ferroptosis in preeclampsia through the p53/SLC7A11 pathway., PMID:40480436
Panose prevents acute-on-chronic liver failure by reducing bacterial infection in mice., PMID:40478727
Protein Kinase D Knockdown Alleviates Vascular Calcification Through P53-SLC7A11 Axis-Mediated Ferroptosis., PMID:40474563
Mechanism of ferroptosis in hypoxia-induced pulmonary vascular remodeling in hypoxia pulmonary hypertension: a study based on the ACE2-Ang-(1-7)-Mas axis., PMID:40466901
Electrochemical sensor toolkit for simultaneous glutamate detection at edge of cleft and peri-soma., PMID:40466640
Targeting SLC7A11-mediated cysteine metabolism for the treatment of trastuzumab-resistant HER2-positive breast cancer., PMID:40464376
Lactate dehydrogenase B facilitates disulfidptosis and exhaustion of tumour-infiltrating CD8+ T cells., PMID:40461882
[Fucoidan sulfate regulates Hmox1-mediated ferroptosis to ameliorate myocardial injury in diabetic cardiomyopathy]., PMID:40461202
Squalene epoxidase promotes paraquat-induced pulmonary toxicity through endoplasmic reticulum-mediated ferroptosis., PMID:40460939
Molecular signatures of disulfidptosis: interplay with programmed cell death pathways and therapeutic implications in oncology., PMID:40457177
Ponicidin triggered ferroptosis in esophageal squamous cell carcinoma by suppressing the SLC7A11/Glutathione/GPX4 signalling axis., PMID:40456202
Hepatic ferroptosis induced by Clonorchis sinensis exacerbates liver fibrosis., PMID:40455823
Prescription FINO2 and Pirfenidone Supported in Reducing Fibrosis in Mouse Breast Tumor Tissue by Targeting SLC7A11 and HMOX1., PMID:40454509
BECN1 regulates ferroptosis induced by 2,4-dichlorophenoxyacetic acid in SH-SY5Y cells., PMID:40451026
CD38 inhibits ferroptosis to promote radiotherapy resistance in nasopharyngeal carcinoma by competitively binding to TRIM21 to stabilize SLC7A11 protein., PMID:40449774
Trim65 mitigates doxorubicin-induced myocardial injury by reducing ferroptosis., PMID:40447212
BAP1 exacerbates inflammatory bowel disease by promoting ferroptosis via SLC7A11 suppression., PMID:40446694
Effects of extreme heat exposure on heatstroke and liver injury in mice: The role of PPARα., PMID:40445822
Multiomics profiles of genome-wide alterations in H3K27ac in different lung lobes after acute graft-versus-host disease with MSCs treatment., PMID:40443676
The role of HMOX1-mediated ferroptosis in blue light-induced damage to retinal pigment epithelium., PMID:40442370
Capsaicin induces ferroptosis via suppression of SLC7A11 activity and upregulation of ACSL4 mediated by AMPK in tongue squamous cell carcinoma., PMID:40438695
Salidroside can protect against ferroptosis in cardiomyocytes and may be related to the regulation of GGT1., PMID:40438595
Valproic acid induces ferroptosis and suppresses the proliferation of MDA-MB-231 cells by targeting FDFT1., PMID:40438588
p53-mediated suppression of the SLC7 A11/GPX4 signaling pathway promotes trophoblast ferroptosis in preeclampsia., PMID:40437575
For research use only. Not for human or drug use.
