Catalog No.
EMD83901
Expression system
Mammalian Cells
Species
Mus musculus (Mouse)
Protein length
Arg23-Ala215
Predicted molecular weight
25.15 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P43431
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-12A, NK cell stimulatory factor chain 1, IL12A, CLMF p35, Interleukin-12 subunit alpha, IL-12 subunit p35, NKSF1, Cytotoxic lymphocyte maturation factor 35 kDa subunit
Association of Interleukin-12A Genotypes With Nasopharyngeal Carcinoma Risk., PMID:40425357
Genetic variant rs2243115 of the IL-12/IL-35 pathway contributes to the risk of coronary artery disease., PMID:40303485
The Contribution of Interleukin-12A and Interleukin-12B Genotypes to Colorectal Cancer in Taiwan., PMID:40155027
Implication of IL-12A, IL-12B, IL-6, and TNF single-nucleotide polymorphisms in severity and susceptibility to COVID-19., PMID:39239824
Expression of STAT3, IL27p28 and IL12p35 is deregulated and linked to autoimmune markers in chronic spontaneous urticaria., PMID:39107251
Prioritizing drug targets in systemic lupus erythematosus from a genetic perspective: a druggable genome-wide Mendelian randomization study., PMID:38997544
Investigation of lactotransferrin messenger RNA expression levels as an anti-type 2 asthma biomarker., PMID:38797239
Signaling pathways underlying TGF-β mediated suppression of IL-12A gene expression in monocytes., PMID:38278031
Nanoscale, antigen encounter-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatment., PMID:36855120
Photoreceptor Cells Constitutively Express IL-35 and Promote Ocular Immune Privilege., PMID:35897732
MEF2C promotes M1 macrophage polarization and Th1 responses., PMID:35194174
Mucosa-Associated Invariant T Cell Hypersensitivity to Staphylococcus aureus Leukocidin ED and Its Modulation by Activation., PMID:35140134
Interleukin-35: Structure, Function and Its Impact on Immune-Related Diseases., PMID:34788131
The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo., PMID:34644571
Local Interleukin-12 Treatment Enhances the Efficacy of Radiation Therapy by Overcoming Radiation-Induced Immune Suppression., PMID:34576217
Contribution of Interleukin-12A Genotypes to Breast Cancer Risk., PMID:34475058
Importance of particle size of oligomannose-coated liposomes for induction of Th1 immunity., PMID:34426114
Circulating Extracellular Vesicles Carry Immune Regulatory miRNAs and Regulate Vaccine Efficacy and Local Inflammatory Response After Vaccination., PMID:34211472
2-Arachidonyl-lysophosphatidylethanolamine Induces Anti-Inflammatory Effects on Macrophages and in Carrageenan-Induced Paw Edema., PMID:34064436
Foxp3 Silencing with Antisense Oligonucleotide Improves Immunogenicity of an Adjuvanted Recombinant Vaccine against Sporothrix schenckii., PMID:33801683
Interaction between the STAT4 rs11889341(T) risk allele and smoking confers increased risk of myocardial infarction and nephritis in patients with systemic lupus erythematosus., PMID:33766895
IL10- and IL35-Secreting MutuDC Lines Act in Cooperation to Inhibit Memory T Cell Activation Through LAG-3 Expression., PMID:33679743
Expression of recombinant DnaK of Brucella abortus and its evaluation as immuno-modulator., PMID:33606039
Retinoid Regulation of Ocular Surface Innate Inflammation., PMID:33499199
Analysis for interaction between interleukin-35 genes polymorphisms and risk factors on susceptibility to coronary heart disease in the Chinese Han population., PMID:33407151
FXTAS presents with upregulation of the cytokines IL12 and TNFα., PMID:33285358
Tim-3 is a potential regulator that inhibits monocyte inflammation in response to intermittent hypoxia in children with obstructive sleep apnea syndrome., PMID:33271370
Reduced IL-35 in patients with immune thrombocytopenia., PMID:33141778
Interleukin-35 in idiopathic inflammatory myopathies., PMID:33128920
Development of an immunocompetent mouse model susceptible to Cryptosporidium tyzzeri infection., PMID:33068486
Associations between hepatocellular carcinoma risk and rs3212227 and rs568408 polymorphisms: a systematic review and meta-analysis., PMID:32809897
The Contribution of Interleukin-12A Genotypes to Oral Cancer Risk in Taiwanese., PMID:32620609
Detecting tumor-infiltrating Forkhead box P3-positive T cells in the prognosis of lung adenocarcinoma: Possible role of clustering tumor interleukin-12 subunit alpha and transforming growth factor beta 1 expression., PMID:32603557
Interaction analysis of IL-12A and IL-12B gene variants with chronic hepatitis B infection in Tunisian patients., PMID:32554051
Effects of B cell-activating factor on tumor immunity., PMID:32434989
IL-23, but not IL-12, plays a critical role in inflammation-mediated bone disorders., PMID:32226529
Dynamic changes of innate lymphoid cells in acute ST-segment elevation myocardial infarction and its association with clinical outcomes., PMID:32198366
IL-35 promotes microglial M2 polarization in a rat model of diabetic neuropathic pain., PMID:32156533
Long non-coding RNA X-inactive specific transcript silencing ameliorates primary graft dysfunction following lung transplantation through microRNA-21-dependent mechanism., PMID:31981974
Evaluation of the relationship between IL-12, IL-13 and TNF-α gene polymorphisms with the susceptibility to brucellosis: a case control study., PMID:31818255
Type 1 Innate Lymphoid Cells Protect Mice from Acute Liver Injury via Interferon-γ Secretion for Upregulating Bcl-xL Expression in Hepatocytes., PMID:31810881
LmjMAPK10 offers protection against Leishmania donovani infection., PMID:31770453
P2Y6 signaling in alveolar macrophages prevents leukotriene-dependent type 2 allergic lung inflammation., PMID:31638598
Enteric bacteria induce IFNγ and Granzyme B from human colonic Group 1 Innate Lymphoid Cells., PMID:31583949
Enhanced protection against Q fever in BALB/c mice elicited by immunization of chloroform-methanol residue of Coxiella burnetii via intratracheal inoculation., PMID:31477436
Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3., PMID:31472403
Interferon-γ and interleukin-12 production in relation to gene polymorphisms in bacillus Calmette-Guérin osteitis., PMID:31465608
Plasmacytoid dendritic cells protect against immune-mediated acute liver injury via IL-35., PMID:31264967
Interleukin-35 is associated with the tumorigenesis and progression of prostate cancer., PMID:31186721
Characterization of two novel mutations in IL-12R signaling in MSMD patients., PMID:31158284
For research use only. Not for human or drug use.
