Catalog No.
RHP06201
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
IHC: 1:500-1:1000
Target
Zinc finger protein Helios, Ikaros family zinc finger protein 2, ZNFN1A2, IKZF2, HELIOS
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9UKS7
Applications
IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R4D02
Single-centre comparison of non-familial, familial and monogenic lupus., PMID:40465409
Sequential transcriptome profiling: comparative analysis of normal and canine lymphoma preceding detailed T-cell and B-cell subtype comparison., PMID:39911484
Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants., PMID:39731908
KIR2DL2/DL3+NKs and Helios+Tregs in Peripheral Blood Predict Nivolumab Response in Patients with Metastatic Renal Cell Cancer., PMID:39167621
SingleNucleotide Polymorphisms as Biomarkers of Mepolizumab and Benralizumab Treatment Response in Severe Eosinophilic Asthma., PMID:39125709
TLR7 enhancing follicular helper T (Tfh) cells response in C57BL/6 mice infected with Plasmodium yoelii NSM TLR7 mediated Tfh cells in P. yoelii infected mice., PMID:38150744
IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function., PMID:35003100
An autologous culture model of nodal B-cell lymphoma identifies ex vivo determinants of response to bispecific antibodies., PMID:34587238
Ikzf2 Regulates the Development of ICOS+ Th Cells to Mediate Immune Response in the Spleen of S. japonicum-Infected C57BL/6 Mice., PMID:34475870
Coexpression of Helios in Foxp3+ Regulatory T Cells and Its Role in Human Disease., PMID:34257746
Helios-Negative Regulatory T Cells as a Key Factor of Immune Tolerance in Nonallergic Beekeepers., PMID:34213416
Differences in Maturation Status and Immune Phenotypes of Circulating Helios+ and Helios- Tregs and Their Disrupted Correlations With Monocyte Subsets in Autoantibody-Positive T1D Individuals., PMID:34054801
Terminal Effector CD8 T Cells Defined by an IKZF2+IL-7R- Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity., PMID:31519862
Distinct Alterations in the Composition of Mucosal Innate Lymphoid Cells in Newly Diagnosed and Established Crohn's Disease and Ulcerative Colitis., PMID:30496425
Circulating integrin alpha4/beta7+ lymphocytes targeted by vedolizumab have a pro-inflammatory phenotype., PMID:29842945
Partial CD25 Antagonism Enables Dominance of Antigen-Inducible CD25high FOXP3+ Regulatory T Cells As a Basis for a Regulatory T Cell-Based Adoptive Immunotherapy., PMID:29312311
Helios + Regulatory T cell frequencies are correlated with control of viral replication and recovery of absolute CD4 T cells counts in early HIV-1 infection., PMID:29246111
Helios Enhances Treg Cell Function in Cooperation With FoxP3., PMID:25733061
Natural and inducible Tregs in swine: Helios expression and functional properties., PMID:25511662
Th1/Th17 plasticity is a marker of advanced β cell autoimmunity and impaired glucose tolerance in humans., PMID:25480564
In vitro TNF blockade enhances ex vivo expansion of regulatory T cells in patients with immune thrombocytopenia., PMID:25252160
Differential control of Helios(+/-) Treg development by monocyte subsets through disparate inflammatory cytokines., PMID:23365462
HELIOS-BCL11B fusion gene involvement in a t(2;14)(q34;q32) in an adult T-cell leukemia patient., PMID:22867996
Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy., PMID:21911743
For research use only. Not for human or drug use.
