Catalog No.
RHN97802
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
C5a anaphylatoxin chemotactic receptor 2, GPR77, Complement component 5a receptor 2, G-protein coupled receptor 77, C5L2, C5AR2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9P296
Applications
ELISA, FCM, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R4B86
Structure of Designer Antibody-like Peptides Binding to the Human C5a with Potential to Modulate the C5a Receptor Signaling., PMID:39051153
The complement cascade in lung injury and disease., PMID:38178176
Rational design of antibody-like peptides for targeting the human complement fragment protein C5a., PMID:37933678
The role of C5a receptors in autoimmunity., PMID:37598588
The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita., PMID:37275893
The anaphylatoxin C5a: Structure, function, signaling, physiology, disease, and therapeutics., PMID:36989901
Therapeutic Strategies for COVID-19 Patients: An Update., PMID:35319396
C5aR2 Deficiency Ameliorates Inflammation in Murine Epidermolysis Bullosa Acquisita by Regulating Fcγ Receptor Expression on Neutrophils., PMID:35007559
Role of Complement and Histones in Sepsis., PMID:33425963
Characterization of Anaphylatoxin Receptor Expression and C3a/C5a Functions in Anaphylatoxin Receptor Reporter Mice., PMID:32710701
Complement as a Major Inducer of Harmful Events in Infectious Sepsis., PMID:32187106
Evaluation of the Safety and Efficacy of Avacopan, a C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Treated Concomitantly With Rituximab or Cyclophosphamide/Azathioprine: Protocol for a Randomized, Double-Blind, Active-Controlled, Phase 3 Trial., PMID:32088663
Resolution in bullous pemphigoid., PMID:31732776
IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction., PMID:30258440
Enhanced activation of interleukin-10, heme oxygenase-1, and AKT in C5aR2-deficient mice is associated with protection from ischemia reperfusion injury-induced inflammation and fibrosis., PMID:29935951
The critical role of C5a as an initiator of neutrophil-mediated autoimmune inflammation of the joint and skin., PMID:29602515
Tissue Destruction in Bullous Pemphigoid Can Be Complement Independent and May Be Mitigated by C5aR2., PMID:29599777
A Novel Role for C5a in B-1 Cell Homeostasis., PMID:29520270
CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness., PMID:29395328
Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors., PMID:28952876
New concepts on the therapeutic control of complement anaphylatoxin receptors., PMID:28576324
Complement and sepsis-induced heart dysfunction., PMID:27931779
C5L2, the Second C5a Anaphylatoxin Receptor, Suppresses LPS-Induced Acute Lung Injury., PMID:27285858
A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA., PMID:25917104
C5a receptor (CD88) blockade protects against MPO-ANCA GN., PMID:24179165
Disruption of the complement anaphylatoxin receptor C5L2 exacerbates inflammation in allergic contact dermatitis., PMID:24043888
A pro-inflammatory role of C5L2 in C5a-primed neutrophils for ANCA-induced activation., PMID:23785491
Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology., PMID:23394121
TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2., PMID:21630250
Inhibiting the C5-C5a receptor axis., PMID:21549429
Complement dependency of cardiomyocyte release of mediators during sepsis., PMID:21478262
The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction., PMID:20044484
Functional roles for C5a receptors in sepsis., PMID:18454156
Acylation-stimulating protein/C5L2-neutralizing antibodies alter triglyceride metabolism in vitro and in vivo., PMID:17711993
The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding., PMID:17158873
Evidence for a functional role of the second C5a receptor C5L2., PMID:15784721
Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans., PMID:15634936
A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells., PMID:11090875
For research use only. Not for human or drug use.
