Catalog No.
RHN88903
Species reactivity
Human, Monkey
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:50-1:200, IHC: 1:200-1:1000, WB: 1:500-1:2000
Target
3D3/LYRIC, AEG1, LYRIC, AEG-1, MTDH, Lysine-rich CEACAM1 co-isolated protein, Astrocyte elevated gene-1 protein, Protein LYRIC, Metadherin, Metastasis adhesion protein
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q86UE4
Applications
ELISA, FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R4A59
Astrocyte Elevated Gene-1/Metadherin (AEG-1/MTDH): A Promising Molecular Marker and Therapeutic Target for Hepatocellular Carcinoma., PMID:40282551
MTDH antisense oligonucleotides reshape the immunosuppressive tumor microenvironment to sensitize Hepatocellular Carcinoma to immune checkpoint blockade therapy., PMID:35609735
Metadherin (AEG-1/MTDH/LYRIC) expression: Significance in malignancy and crucial role in colorectal cancer., PMID:35152973
Elevated expression of MTDH predicts better prognosis of locally advanced HER-2 positive breast cancer patients receiving neoadjuvant chemotherapy plus trastuzumab., PMID:31490377
miR-217 suppresses proliferation, migration, and invasion promoting apoptosis via targeting MTDH in hepatocellular carcinoma., PMID:28184926
[Preparation and application of mouse anti-AEG-1 monoclonal antibody]., PMID:27916103
Bonafide Targets of Deregulated microRNAs in Non-Small Cell Lung Cancer as Tool to Identify Novel Therapeutic Targets: A Review., PMID:27719642
IL-8 interacts with metadherin promoting proliferation and migration in gastric cancer., PMID:27565732
AEG-1 activates Wnt/PCP signaling to promote metastasis in tongue squamous cell carcinoma., PMID:26689985
Immunohistochemistry-based prognostic biomarkers in NSCLC: novel findings on the road to clinical use?, PMID:25599124
MTDH mediates trastuzumab resistance in HER2 positive breast cancer by decreasing PTEN expression through an NFκB-dependent pathway., PMID:25417825
AEG-1/MTDH/LYRIC: clinical significance., PMID:23889987
Identification of cell surface proteins as potential immunotherapy targets in 12 pediatric cancers., PMID:23251904
Prognostic impact of Metadherin-SND1 interaction in colon cancer., PMID:23065261
Gold nanoparticle probes: design and in vitro applications in cancer cell culture., PMID:22070896
Molecular mimicry of human endothelial cell antigen by autoantibodies to nonstructural protein 1 of dengue virus., PMID:21233208
Expression patterns of astrocyte elevated gene-1 (AEG-1) during development of the mouse embryo., PMID:20736086
A new approach for in vitro imaging of breast cancer cells by anti-metadherin targeted PVA-pyrene., PMID:20336700
Alternaria alternata NADP-dependent mannitol dehydrogenase is an important fungal allergen., PMID:17177674
Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1., PMID:15927426
Metadherin, a cell surface protein in breast tumors that mediates lung metastasis., PMID:15093543
3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus., PMID:14980505
For research use only. Not for human or drug use.
