Catalog No.
RHK97702
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000
Target
JAM-3, JAM-C, JAM-2, Junctional adhesion molecule 3, Junctional adhesion molecule C, sJAM-C, JAM3
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9BX67
Applications
ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3Z66
Threonine attenuates lipopolysaccharide-induced intestinal inflammatory responses in rabbits., PMID:39549129
Genetic deletion of JAM-C in preleukemic cells rewires leukemic stem cell gene expression program in AML., PMID:38954834
Junctional adhesion molecule 3 is a potential therapeutic target for small cell lung carcinoma., PMID:36990421
Surfaceome Profiling of Cell Lines and Patient-Derived Xenografts Confirm FGFR4, NCAM1, CD276, and Highlight AGRL2, JAM3, and L1CAM as Surface Targets for Rhabdomyosarcoma., PMID:36768928
Epigenetic silencing of JAM3 promotes esophageal cancer development by activating Wnt signaling., PMID:36461092
Analyzing normal and disrupted leukemic stem cell adhesion to bone marrow stromal cells by single-molecule tracking nanoscopy., PMID:34435622
Flow Cytometry Analysis of Mouse Hematopoietic Stem and Multipotent Progenitor Cells., PMID:34057715
Immunoglobulin superfamily receptor Junctional adhesion molecule 3 (Jam3) requirement for melanophore survival and patterning during formation of zebrafish stripes., PMID:33933422
Dietary addition of garlic straw improved the intestinal barrier in rabbits1., PMID:31433053
CIRP Induces Neutrophil Reverse Transendothelial Migration in Sepsis., PMID:30148763
Targeting junctional adhesion molecule-C ameliorates sepsis-induced acute lung injury by decreasing CXCR4+ aged neutrophils., PMID:30088666
Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice., PMID:29753567
JAM3 maintains leukemia-initiating cell self-renewal through LRP5/AKT/β-catenin/CCND1 signaling., PMID:29584620
Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis., PMID:28617811
JAM-C maintains VEGR2 expression to promote retinal pigment epithelium cell survival under oxidative stress., PMID:28203682
Anti-JAM-C therapy eliminates tumor engraftment in a xenograft model of mantle cell lymphoma., PMID:27256571
Reverse-migrated neutrophils regulated by JAM-C are involved in acute pancreatitis-associated lung injury., PMID:26841848
Loss of JAM-C leads to impaired esophageal innervations and megaesophagus in mice., PMID:26123848
Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo., PMID:26047922
Blocking junctional adhesion molecule C enhances dendritic cell migration and boosts the immune responses against Leishmania major., PMID:25474593
JAM-C promotes lymphangiogenesis and nodal metastasis in non-small cell lung cancer., PMID:24584816
Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells., PMID:24357068
Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer., PMID:23825230
Homing of human B cells to lymphoid organs and B-cell lymphoma engraftment are controlled by cell adhesion molecule JAM-C., PMID:23221386
The Junctional Adhesion Molecule-B regulates JAM-C-dependent melanoma cell metastasis., PMID:23068611
Targeting of junctional adhesion molecule-C inhibits experimental choroidal neovascularization., PMID:22323465
JAM-C is an apical surface marker for neural stem cells., PMID:22114908
Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves., PMID:22090315
Neutrophils, reverse traffic and detrimental potential., PMID:21874043
JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow., PMID:21868569
Tight junction proteins expression and modulation in immune cells and multiple sclerosis., PMID:21762372
The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo., PMID:21706006
Cutting edge: JAM-C controls homeostatic chemokine secretion in lymph node fibroblastic reticular cells expressing thrombomodulin., PMID:21685324
A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis., PMID:21593193
Junctional adhesion molecules are required for melanoma cell lines transendothelial migration in vitro., PMID:21466663
Neuroscience. Ubiquitination inhibits neuronal exit., PMID:21205656
Siah regulation of Pard3A controls neuronal cell adhesion during germinal zone exit., PMID:21109632
Endothelial lumen signaling complexes control 3D matrix-specific tubulogenesis through interdependent Cdc42- and MT1-MMP-mediated events., PMID:20215637
Cooperative expression of junctional adhesion molecule-C and -B supports growth and invasion of glioma., PMID:19795504
Junctional adhesion molecule (JAM)-B supports lymphocyte rolling and adhesion through interaction with alpha4beta1 integrin., PMID:19740376
Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury., PMID:19574560
Importance of junctional adhesion molecule-C for neointimal hyperplasia and monocyte recruitment in atherosclerosis-prone mice-brief report., PMID:19520977
Adaptive immune response in JAM-C-deficient mice: normal initiation but reduced IgG memory., PMID:19342649
Evidence for cross-reactivity of JAM-C antibodies: implications for cellular localization studies., PMID:19143587
Genetic deletion of JAM-C reveals a role in myeloid progenitor generation., PMID:19109565
Expression, localization, and function of junctional adhesion molecule-C (JAM-C) in human retinal pigment epithelium., PMID:19060272
Junctional adhesion molecule C mediates leukocyte adhesion to rheumatoid arthritis synovium., PMID:18821692
[JAM-C, adhesion molecule or intercellular junctional organizer: lessons from knock-out mice]., PMID:18789204
Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice., PMID:18055550
Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves., PMID:18048693
For research use only. Not for human or drug use.
