Anti-P2RY12 Antibody (R3Z64)

Catalog No.

RHK97002

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

ELISA: 1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000

Target

HORK3, P2T(AC), P2Y(AC), P2Y(cyc), P2Y purinoceptor 12, P2Y(ADP), ADP-glucose receptor, P2RY12, ADPG-R, SP1999, P2Y12, P2Y12 platelet ADP receptor

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9H244

Applications

ELISA, FCM, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3Z64

Reliable detection of RNA in hippocampus sections of mice by FISH up to a post-mortem delay of 24 h., PMID:38582805

Early involvement of peripherally derived monocytes in inflammation in an NMO-like mouse model., PMID:38216632

A Distinct Microglial Cell Population Expressing Both CD86 and CD206 Constitutes a Dominant Type and Executes Phagocytosis in Two Mouse Models of Retinal Degeneration., PMID:37762541

Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis., PMID:37715818

The profile of inflammatory extracellular vesicles in intracerebral hemorrhage patients., PMID:40129971

Involvement of P2Y12 receptors in a nitroglycerin-induced model of migraine in male mice., PMID:34363208

High-parameter cytometry unmasks microglial cell spatio-temporal response kinetics in severe neuroinflammatory disease., PMID:34311763

Transcriptome of microglia reveals a species-specific expression profile in bovines with conserved and new signature genes., PMID:33811399

Purinergic Signaling in Pancreas-From Physiology to Therapeutic Strategies in Pancreatic Cancer., PMID:33233631

A new genetic strategy for targeting microglia in development and disease., PMID:32573436

Association between P2RY12 Gene Polymorphisms and IVIG Resistance in Kawasaki Patients., PMID:32256707

Potential and Limitations of the New P2Y12 Inhibitor, Cangrelor, in Preventing Heparin-Induced Platelet Aggregation During Cardiac Surgery: An In Vitro Study., PMID:32102014

Role of Platelet Size Revisited-Function and Protein Composition of Large and Small Platelets., PMID:30727004

Suppressing Interferon-γ Stimulates Microglial Responses and Repair of Microbleeds in the Diabetic Brain., PMID:30201775

The role of agonist-induced activation and inhibition for the regulation of purinergic receptor expression in human platelets., PMID:29902630

Modulation of Hematopoietic Lineage Specification Impacts TREM2 Expression in Microglia-Like Cells Derived From Human Stem Cells., PMID:28683563

Contribution of platelet P2Y12 receptors to chronic Complete Freund's adjuvant-induced inflammatory pain., PMID:28345287

Targeting of C-type lectin-like receptor 2 or P2Y12 for the prevention of platelet activation by immunotherapeutic CpG oligodeoxynucleotides., PMID:28296036

Morphological and Molecular Characterization of Human Dermal Lymphatic Collectors., PMID:27764183

A randomized trial assessing the impact of three different glycoprotein IIb/IIIa antagonists on glycoprotein IIb/IIIa platelet receptor inhibition and clinical endpoints in patients with acute coronary syndromes., PMID:27327862

Arginase-1 is expressed exclusively by infiltrating myeloid cells in CNS injury and disease., PMID:27126514

In Vitro Binding of [³H]PSB-0413 to P2Y₁₂ Receptors., PMID:26646192

Toll like receptor 2/1 mediated platelet adhesion and activation on bacterial mimetic surfaces is dependent on src/Syk-signaling and purinergic receptor P2X1 and P2Y12 activation., PMID:25553878

CalDAG-GEFI deficiency protects mice from FcγRIIa-mediated thrombotic thrombocytopenia induced by CD40L and β2GPI immune complexes., PMID:25287077

Dual-contrast molecular imaging allows noninvasive characterization of myocardial ischemia/reperfusion injury after coronary vessel occlusion in mice by magnetic resonance imaging., PMID:24951772

P2Y12 receptor blockade augments glycoprotein IIb-IIIa antagonist inhibition of platelet activation, aggregation, and procoagulant activity., PMID:23676293

[Primary coronary angioplasty for myocardial infarction--the view of the cardiologic surgeon]., PMID:23098611

Isoflurane prevents acute lung injury through ADP-mediated platelet inhibition., PMID:22828148

Platelet glycoprotein VI dimerization, an active process inducing receptor competence, is an indicator of platelet reactivity., PMID:22155453

CalDAG-GEFI deficiency protects mice in a novel model of Fcγ RIIA-mediated thrombosis and thrombocytopenia., PMID:21652673

[Clopidogrel resistance in patients with acute coronary syndrome]., PMID:20873239

Antagonism of P2Y12 or GPIIb/IIIa receptors reduces platelet-mediated myocardial injury after ischaemia and reperfusion in isolated rat hearts., PMID:20431845

Purinergic receptors in the rat lens: activation of P2X receptors following hyperosmotic stress., PMID:20335601

P2Y12 receptor-mediated integrin-beta1 activation regulates microglial process extension induced by ATP., PMID:20091784

RGD-ligand mimetic antagonists of integrin alphaIIbbeta3 paradoxically enhance GPVI-induced human platelet activation., PMID:20002543

Human pancreatic islets express the purinergic P2Y11 and P2Y12 receptors., PMID:18726826

Thrombin regulates intracellular cyclic AMP concentration in human platelets through phosphorylation/activation of phosphodiesterase 3A., PMID:17392505

Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques., PMID:17334511

Distinct clathrin-coated pits sort different G protein-coupled receptor cargo., PMID:16899088

Critical role of ADP interaction with P2Y12 receptor in the maintenance of alpha(IIb)beta3 activation: association with Rap1B activation., PMID:16706985

Flagellin of Pseudomonas aeruginosa inhibits Na+ transport in airway epithelia., PMID:16410345

Glycoprotein IIb/IIIa and P2Y12 receptor antagonists yield additive inhibition of platelet aggregation, granule secretion, soluble CD40L release and procoagulant responses., PMID:16236601

Synergistic action between inhibition of P2Y12/P2Y1 and P2Y12/thrombin in ADP- and thrombin-induced human platelet activation., PMID:15265806

Pharmacodynamic profile of antiplatelet agents: marked differences between single versus costimulation with platelet activators., PMID:15183041

Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin., PMID:15078882

Differential effects of P2Y1 and P2Y12 nucleotide receptors on ERK1/ERK2 and phosphatidylinositol 3-kinase signalling and cell proliferation in serum-deprived and nonstarved glioma C6 cells., PMID:14718252

The relative importance of the ADP receptors, P2Y12 and P2Y1, in thrombin-induced platelet activation., PMID:14644082

Selective expression of Gi/o-coupled ATP receptor P2Y12 in microglia in rat brain., PMID:14603465

[Platelet inhibitors: old and new]., PMID:12698552

Distinct roles of GPVI and integrin alpha(2)beta(1) in platelet shape change and aggregation induced by different collagens., PMID:12183336

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Anti-P2RY12 Antibody (R3Z64).pdf