Catalog No.
RHK71001
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, IP: 1:100-1:200
Target
p115-RhoGEF, p115RhoGEF, 115 kDa guanine nucleotide exchange factor, Sub1.5, Rho guanine nucleotide exchange factor 1, ARHGEF1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q92888
Applications
IHC, IP
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3Z31
Identification of Giant Isoforms of Obscurin in Rat Striated Muscles Using Polyclonal Antibodies., PMID:39441441
SP-R210 isoforms of Myosin18A modulate endosomal sorting and recognition of influenza A virus infection in macrophages., PMID:38135024
Dynamic encounters with red blood cells trigger splenic marginal zone B cell retention and function., PMID:38049580
Rs7537605 polymorphism in VAV3 gene and rs28665122 polymorphism in SEPS gene are not associated with Hashimoto's thyroiditis in North-East Algerian population., PMID:37092056
Autophagy Induced by Toll-like Receptor Ligands Regulates Antigen Extraction and Presentation by B Cells., PMID:36497137
CD16+ fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition., PMID:36379207
Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes., PMID:36111670
A commercial ARHGEF17/TEM4 antibody cross-reacts with Nuclear Mitotic Apparatus protein 1 (NuMA)., PMID:35776709
Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics., PMID:34582006
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling., PMID:34526379
Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation., PMID:34471108
CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation., PMID:33879857
Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias., PMID:33753942
BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation., PMID:33534893
Expression analyses of PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, during mouse brain development., PMID:33492483
Vav family proteins constitute disparate branching points for distinct BCR signaling pathways., PMID:32671844
Efficacy of high-dose corticosteroid-based treatment for chronic lymphocytic leukemia patients with p53 abnormalities in the era of B-cell receptor inhibitors., PMID:32659728
Expression of DOCK10.1 protein revealed with a specific antiserum: insights into regulation of first exon isoforms of DOCK10., PMID:32112301
B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota., PMID:31433298
TLR induces reorganization of the IgM-BCR complex regulating murine B-1 cell responses to infections., PMID:31433296
Inhibition of allogeneic islet graft rejection by VISTA-conjugated liposome., PMID:31272717
NKG2D-DAP10 signaling recruits EVL to the cytotoxic synapse to generate F-actin and promote NK cell cytotoxicity., PMID:31235500
Distinct immunoglobulin heavy chain variable region gene repertoire and lower frequency of del(11q) in Taiwanese patients with chronic lymphocytic leukaemia., PMID:31230372
The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells., PMID:31197029
Overexpression of PODXL/ITGB1 and BCL7B/ITGB1 accurately predicts unfavorable prognosis compared to the TNM staging system in postoperative pancreatic cancer patients., PMID:31166991
Congenital Defects in Actin Dynamics of Germinal Center B Cells., PMID:30894852
Lyn is involved in host defense against S. agalactiae infection and BCR signaling in Nile tilapia (Oreochromis niloticus)., PMID:30822451
ARHGEF1 deficiency reveals Gα13-associated GPCRs are critical regulators of human lymphocyte function., PMID:30714991
Wnt5a causes ROR1 to complex and activate cortactin to enhance migration of chronic lymphocytic leukemia cells., PMID:30568170
Loss of ARHGEF1 causes a human primary antibody deficiency., PMID:30521495
A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire., PMID:30410484
Profiling the origin, dynamics, and function of traction force in B cell activation., PMID:30087179
Expression of novel "LOCGEF" isoforms of ARHGEF18 in eosinophils., PMID:29601110
Targeting the B-cell receptor pathway in diffuse large B-cell lymphoma., PMID:29549872
Nongenetic origins of cell-to-cell variability in B lymphocyte proliferation., PMID:29514960
RETRACTED: Bach2 regulates aberrant activation of B cell in systemic lupus erythematosus and can be negatively regulated by BCR-ABL/PI3K., PMID:29501569
Intravital Imaging of B Cell Responses in Lymph Nodes., PMID:29476489
The gp130 Cytokine Interleukin-11 Regulates Engraftment of Vav1-/- Hematopoietic Stem and Progenitor Cells in Lethally Irradiated Recipients., PMID:29235178
Mycobacterium tuberculosis Mce3C promotes mycobacteria entry into macrophages through activation of β2 integrin-mediated signalling pathway., PMID:29125705
Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity., PMID:28973398
A Novel Vav3 Homolog Identified in Lamprey, Lampetra japonica, with Roles in Lipopolysaccharide-Mediated Immune Response., PMID:28937614
Advantages of targeting B cell receptor complex to treat B-cell derived autoimmune diseases and lymphomas., PMID:28644972
MYC protein dysregulation is driven by BCR-PI3K signalling in diffuse large B-cell lymphoma., PMID:28639315
SNP in human ARHGEF3 promoter is associated with DNase hypersensitivity, transcript level and platelet function, and Arhgef3 KO mice have increased mean platelet volume., PMID:28542600
Targeting ROR1 identifies new treatment strategies in hematological cancers., PMID:28408486
Proteomic Characteristics of Blood Serum in Rats with Different Behavioral Parameters after Acute Stress., PMID:28361418
Expression Profiles Analysis and Functional Characterization of MicroRNA-660 in Skeletal Muscle Differentiation., PMID:28106300
VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis., PMID:28053322
Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection., PMID:27989621
Indoleamine 2,3-dioxygenase regulates T cell activity through Vav1/Rac pathway., PMID:27930920
For research use only. Not for human or drug use.
