Catalog No.
RHK41802
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IF: 1:200-1:1000, IHC: 1:200-1:1000
Target
SK2, Sphingosine kinase 2, SPHK2, SK 2, SPK 2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9NRA0
Applications
ELISA, FCM, IF, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3Y90
Approaches to the Potential Therapy of COVID-19: A General Overview from the Medicinal Chemistry Perspective., PMID:35163923
Sphingosine-1-phosphate mediates the therapeutic effects of bone marrow mesenchymal stem cell-derived microvesicles on articular cartilage defect., PMID:29324234
Validation of commercially available sphingosine kinase 2 antibodies for use in immunoblotting, immunoprecipitation and immunofluorescence., PMID:28105318
Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-γ., PMID:27799486
Sphingosine kinase 1 is required for mesothelioma cell proliferation: role of histone acetylation., PMID:23028939
A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma., PMID:22939756
Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a mouse model of food allergy., PMID:22020265
Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia., PMID:21605625
Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways., PMID:21478254
Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase., PMID:21304987
Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720., PMID:19490468
Interleukin-1 regulates the expression of sphingosine kinase 1 in glioblastoma cells., PMID:19074142
Vascular endothelium as a contributor of plasma sphingosine 1-phosphate., PMID:18258856
(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1., PMID:17699106
IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses., PMID:16316995
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism., PMID:16118219
For research use only. Not for human or drug use.
