Catalog No.
RHK13101
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400
Target
Mas-related G-protein coupled receptor member X2, MRGX2, MRGPRX2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q96LB1
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3Y46
Current and future therapeutics targeting mast cells in disease., PMID:40451557
No relationship between non-IgE-mediated mechanisms (complement activation or direct activation of mast cells and basophils) during diclofenac etalhyaluronate (SI-613/ONO-5704)-induced anaphylaxis., PMID:40314594
Mast Cells at the Crossroads of Hypersensitivity Reactions and Neurogenic Inflammation., PMID:39940696
The development of murine bone marrow-derived mast cells expressing functional human MRGPRX2 for ex vivo and in vivo studies., PMID:39749337
Therapies for Chronic Spontaneous Urticaria: Present and Future Developments., PMID:39598410
MRGPRX2 facilitates IgE-mediated systemic anaphylaxis in a newly established knock-in mouse model., PMID:39581296
Chronic Spontaneous Urticaria: Current and Emerging Biologic Agents., PMID:39389712
Non-IgE-mediated drug-induced hypersensitivity reactions in pediatrics., PMID:39254665
Mrgprb2-dependent Mast Cell Activation Plays a Crucial Role in Acute Colitis., PMID:39179175
A Skin Testing Strategy for Non-IgE-Mediated Reactions Associated With Vancomycin., PMID:39117269
Neuromuscular blocking agent drug challenge: a literature review and protocol proposal with biological evaluation., PMID:38916219
An optimized method for IgE-mediated degranulation of human lung mast cells., PMID:38881896
[KEY RESIDUES IN DRUG-INDUCED IgE-INDEPENDENT PSEUDO-ALLERGIC REACTIONS VIA MAS-RELATED G-PROTEIN COUPLED RECEPTOR X2]., PMID:38880629
Perioperative anaphylaxis: updates on pathophysiology., PMID:38743470
MASTer cell: chief immune modulator and inductor of antimicrobial immune response., PMID:38638437
New insight into prurigo nodularis: Proadrenomedullin N-terminal 20 peptide mediates mouse mast cell activation via Mrgprb2., PMID:38284237
Suspected pholcodine allergy: the conundrum of clinically irrelevant immunoglobulin E and basophil responsiveness to morphine and codeine., PMID:38245453
The Underlying Rab Network of MRGPRX2-Stimulated Secretion Unveils the Impact of Receptor Trafficking on Secretory Granule Biogenesis and Secretion., PMID:38201297
Mechanisms of histamine release from mast cells beyond the high affinity IgE receptor in severe chronic spontaneous urticaria., PMID:38042500
Dual effect of tacrolimus on mast cell-mediated allergy and inflammation through Mas-related G protein-coupled receptor X2., PMID:37953179
Biomarkers of immediate drug hypersensitivity., PMID:37947156
Editorial: The fundamental biology of basophils in health and disease., PMID:37928516
Mast Cells and Basophils in IgE-Independent Anaphylaxis., PMID:37628983
Meglumine gadoterate induces immunoglobulin-independent human mast cell activation via MRGPRX2., PMID:37548384
Effects and potential mechanisms of Saposhnikovia divaricata (Turcz.) Schischk. On type I allergy and pseudoallergic reactions in vitro and in vivo., PMID:37487961
MRGPRX2, drug pseudoallergies, inflammatory diseases, mechanisms and distinguishing MRGPRX2- and IgE/FcεRI-mediated events., PMID:37430437
Substance P analogs devoid of key residues fail to activate human mast cells via MRGPRX2., PMID:37228611
GRK2 differentially regulates FcεRI and MRGPRB2-mediated responses in mast cells., PMID:37063868
Mas-related G protein-coupled receptor MRGPRX2 in human basophils: Expression and functional studies., PMID:36726977
Allergenic and Mas-Related G Protein-Coupled Receptor X2-Activating Properties of Drugs: Resolving the Two., PMID:36581077
Opioid toxicity: histamine, hypersensitivity, and MRGPRX2., PMID:36344690
Recent Knowledge and Insights on the Mechanisms of Immediate Hypersensitivity and Anaphylaxis: IgE/FcεRI- and Non-IgE/FcεRI-Dependent Anaphylaxis., PMID:36284380
GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2., PMID:36275707
Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist., PMID:36275683
Convenient Diaryl Ureas as Promising Anti-pseudo-allergic Agents., PMID:35876064
Flow-based allergen testing: Can mast cells beat basophils?, PMID:35609709
Mas-Related G Protein-Coupled Receptor-X2 and Its Role in Non-immunoglobulin E-Mediated Drug Hypersensitivity., PMID:35469618
Mast cell activation test: A new asset in the investigation of the chlorhexidine cross-sensitization profile., PMID:35305051
Overexpression of FcεRI on Bone Marrow Mast Cells, but Not MRGPRX2, in Clonal Mast Cell Disorders With Wasp Venom Anaphylaxis., PMID:35281031
Tryptase release does not discriminate between IgE- and MRGPRX2-mediated activation in human mast cells., PMID:35152504
Road Less Traveled: Drug Hypersensitivity to Fluoroquinolones, Vancomycin, Tetracyclines, and Macrolides., PMID:35092578
Antibody or Anybody? Considering the Role of MRGPRX2 in Acute Drug-Induced Anaphylaxis and as a Therapeutic Target., PMID:34867939
A paper-based ELISA for rapid sensitive determination of anaphylaxis-related MRGPRX2 in human peripheral blood., PMID:34597615
Roles of IgE and Histamine in Mast Cell Maturation., PMID:34440939
MRGPRX2 and Adverse Drug Reactions., PMID:34421893
Novel Insights on MRGPRX2-Mediated Hypersensitivity to Neuromuscular Blocking Agents And Fluoroquinolones., PMID:34385999
Multifaceted MRGPRX2: New insight into the role of mast cells in health and disease., PMID:33957166
MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis., PMID:33941653
Basophil and mast cell activation tests by flow cytometry in immediate drug hypersensitivity: Diagnosis and beyond., PMID:33933471
Unlocking the Non-IgE-Mediated Pseudo-Allergic Reaction Puzzle with Mas-Related G-Protein Coupled Receptor Member X2 (MRGPRX2)., PMID:33925682
For research use only. Not for human or drug use.
