Catalog No.
RHK12003
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Tested applications
IHC: 1:100-1:200, IP: 1:100-1:200
Target
KIAA0994, Peptidylarginine deiminase II, PADI2, PAD-H19, PDI2, Protein-arginine deiminase type II, Protein-arginine deiminase type-2, PAD2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9Y2J8
Applications
IHC, IP
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3Y44
Sorafenib-induced macrophage extracellular traps via ARHGDIG/IL4/PADI4 axis confer drug resistance through inhibiting ferroptosis in hepatocellular carcinoma., PMID:39529192
Citrullination Accompanies the Development of Carotid Atherosclerotic Plaques., PMID:39421992
Suppressing anti-citrullinated protein antibody-induced osteoclastogenesis in rheumatoid arthritis using anti-CD64 and PAD-2 inhibitors., PMID:39152765
Protein Citrullination by Peptidyl Arginine Deiminase/Arginine Deiminase Homologs in Members of the Human Microbiota and Its Recognition by Anti-Citrullinated Protein Antibodies., PMID:38791230
Vitamin B12 inhibits peptidylarginine deiminases and ameliorates rheumatoid arthritis in CAIA mice., PMID:38401303
Construction of a molecular inflammatory predictive model with histone modification-related genes and identification of CAMK2D as a potential response signature to infliximab in ulcerative colitis., PMID:38274809
Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients., PMID:37759458
Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells., PMID:37310889
Peptidylarginine Deiminase 2 Gene Polymorphisms in Subjects with Periodontitis Predispose to Rheumatoid Arthritis., PMID:36076933
Genetic basis of defects in immune tolerance underlying the development of autoimmunity., PMID:35979360
Peptidylarginine Deiminase 2 Autoantibodies Are Linked to Less Severe Disease in Multiple Sclerosis and Post-treatment Lyme Disease., PMID:35734473
ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation., PMID:35218410
Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts., PMID:35181688
Peptidylarginine Deiminase 2 in Murine Antiviral and Autoimmune Antibody Responses., PMID:35083342
PADI4 Polymorphisms Confer Risk of Anti-CCP-Positive Rheumatoid Arthritis in Synergy With HLA-DRB1*04 and Smoking., PMID:34733271
PADI2 Polymorphisms Are Significantly Associated With Rheumatoid Arthritis, Autoantibodies Serologic Status and Joint Damage in Women from Southern Mexico., PMID:34421923
Protein citrullination as a source of cancer neoantigens., PMID:34112737
The Expression of Non-Coding RNAs and Their Target Molecules in Rheumatoid Arthritis: A Molecular Basis for Rheumatoid Pathogenesis and Its Potential Clinical Applications., PMID:34073629
Epitope-Based Chicken-Derived Novel Anti-PAD2 Monoclonal Antibodies Inhibit Citrullination., PMID:33937418
The Essential Role of Peptidylarginine Deiminases 2 for Cytokines Secretion, Apoptosis, and Cell Adhesion in Macrophage., PMID:32785008
Citrulline Not a Major Determinant in the Recognition of Peptidylarginine Deiminase 2 and 4 by Autoantibodies in Rheumatoid Arthritis., PMID:32255561
Citrullinated Histone H3 as a Therapeutic Target for Endotoxic Shock in Mice., PMID:31998291
Neutrophil extracellular traps, B cells, and type I interferons contribute to immune dysregulation in hidradenitis suppurativa., PMID:31484788
A Novel Citrullinated Modification of Histone 3 and Its Regulatory Mechanisms Related to IPO-38 Antibody-Labeled Protein., PMID:31058095
Increased peptidylarginine deiminases expression during the macrophage differentiation and participated inflammatory responses., PMID:31039829
Autoantibodies to Peptidylarginine Deiminase 2 Are Associated With Less Severe Disease in Rheumatoid Arthritis., PMID:30515171
Relative efficiencies of peptidylarginine deiminase 2 and 4 in generating target sites for anti-citrullinated protein antibodies in fibrinogen, alpha-enolase and histone H3., PMID:30161253
Murine Retinal Citrullination Declines With Age and is Mainly Dependent on Peptidyl Arginine Deiminase 4 (PAD4)., PMID:30073354
Increased citrullination and expression of peptidylarginine deiminases independently of P. gingivalis and A. actinomycetemcomitans in gingival tissue of patients with periodontitis., PMID:30064459
Hypoxia induces production of citrullinated proteins in human fibroblast-like synoviocytes through regulating HIF1α., PMID:29484680
Upregulation of citrullination pathway: From Autoimmune to Idiopathic Lung Fibrosis., PMID:29287593
The expression of mRNA for peptidylarginine deiminase type 2 and type 4 in bone marrow CD34+ cells in rheumatoid arthritis., PMID:29148420
High-Titer Rheumatoid Arthritis Antibodies Preferentially Bind Fibrinogen Citrullinated by Peptidylarginine Deiminase 4., PMID:28029744
A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22., PMID:27777982
Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice., PMID:27150598
Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase., PMID:27149996
Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF/TOF., PMID:27060082
Increased levels of peptidylarginine deiminase 2 in synovial fluid from anti-CCP-positive rheumatoid arthritis patients: Association with disease activity and inflammatory markers., PMID:26880831
The amount of citrullinated proteins in synovial tissue is related to serum anti-cyclic citrullinated peptide (anti-CCP) antibody levels., PMID:26255191
Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid., PMID:26245941
Mass spectrometric identification of citrullination sites and immunohistochemical detection of citrullinated glial fibrillary acidic protein in Alzheimer's disease brains., PMID:26190193
Smoking is associated with increased levels of extracellular peptidylarginine deiminase 2 (PAD2) in the lungs., PMID:25897949
Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen., PMID:25475141
Vimentin is involved in peptidylarginine deiminase 2-induced apoptosis of activated Jurkat cells., PMID:24850148
Generation of monoclonal antibodies against peptidylarginine deiminase 2 (PAD2) and development of a PAD2-specific enzyme-linked immunosorbent assay., PMID:24384061
Retinal deimination and PAD2 levels in retinas from donors with age-related macular degeneration (AMD)., PMID:23562679
Lessons to be learned from periodontitis., PMID:23370377
Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis., PMID:23164236
Contact with stimulated T cells up-regulates expression of peptidylarginine deiminase 2 and 4 by human monocytes., PMID:22614825
Neuronal PAD4 expression and protein citrullination: possible role in production of autoantibodies associated with neurodegenerative disease., PMID:22560840
For research use only. Not for human or drug use.
